• The Guardians are -185 favorites vs the White Sox
• White Sox vs Guardians Over / Under today: 7 Runs
• White Sox / Guardians TV Channel: ESPN

The Chicago White Sox (+150) visit Progressive Field to take on the Cleveland Guardians (-185) on September 16, 2026. First pitch is scheduled for 1:10 pm in Cleveland, OH.

This season, the White Sox are 77-74 against the spread (ATS), while the Guardians are 69-82 ATS.

White Sox vs Guardians Starting Pitchers Today:

• White Sox starting pitcher: Anthony Kay 9-9, 4.52 ERA
• Guardians starting pitcher: Parker Messick 11-9, 2.53 ERA

White Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

White Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 62.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Miguel Vargas has hit the Singles Over in 18 of his last 25 games (+14.55 Units / 58% ROI)
• Munetaka Murakami has hit the Hits Runs and RBIs Under in 20 of his last 25 games (+13.70 Units / 43% ROI)
• Munetaka Murakami has hit the Total Bases Under in 19 of his last 25 games (+13.15 Units / 43% ROI)
• Anthony Kay has hit the Walks Allowed Under in 18 of his last 25 games (+12.60 Units / 43% ROI)
• Randal Grichuk has hit the Hits Over in 14 of his last 15 games (+12.20 Units / 49% ROI)

And here are some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

• Travis Bazzana has hit the Home Runs Over in 3 of his last 7 games (+18.90 Units / 270% ROI)
• Jose Ramirez has hit the RBIs Under in 22 of his last 25 games (+15.85 Units / 31% ROI)
• Jose Ramirez has hit the Total Bases Under in 13 of his last 15 games (+10.40 Units / 46% ROI)
• Parker Messick has hit the Earned Runs Under in 12 of his last 15 games (+9.80 Units / 52% ROI)
• Travis Bazzana has hit the Runs Under in 16 of his last 20 games at home (+9.35 Units / 25% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 31 of their last 50 away games (+9.90 Units / 16% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 26 of their last 40 away games (+9.05 Units / 19% ROI)
• The Chicago White Sox have hit the Team Total Under in 11 of their last 17 games (+4.20 Units / 21% ROI)
• The Chicago White Sox have hit the Game Total Over in 23 of their last 40 games (+3.80 Units / 9% ROI)
• The Chicago White Sox have covered the Run Line in 23 of their last 40 away games (+3.65 Units / 6% ROI)

Guardians Best Bets Today:

• The Cleveland Guardians have hit the Game Total Over in 11 of their last 17 games (+4.55 Units / 25% ROI)
• The Cleveland Guardians have hit the Moneyline in 16 of their last 25 games (+4.35 Units / 12% ROI)
• The Cleveland Guardians have hit the Team Total Over in 6 of their last 8 games (+3.80 Units / 41% ROI)
• The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 19 games (+2.10 Units / 9% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 83-65 against the Run Line (+2.8 Units / 1.32% ROI).

• 77-74 when betting on the Moneyline for +9 Units / 5.48% ROI
• 85-64 when betting on the total runs Over for +14.45 Units / 8.71% ROI
• 64-85 when betting on the total runs Under for -29.8 Units / -17.92% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 69-82 against the Run Line (-18.85 Units / -9.77% ROI).

• 77-75 when betting on the Moneyline for -7.5 Units / -3.95% ROI
• 73-78 when betting on the total runs Over for -11.65 Units / -7.05% ROI
• 78-73 when betting on the total runs Under for -3.3 Units / -1.95% ROI

White Sox Keys to the Game vs. the Guardians

The White Sox are 41-23 (.641) vs bottom 10 scoring offenses this season Today, they face the Guardians (27th in runs scored).

The White Sox are 12-7 (.632) when tied entering the 8th inning this season — 5th best in MLB.

The White Sox are 15-5 (.750) when tied entering the 7th inning this season — 2nd best in MLB.

The White Sox are just 30-14 (.682) when they’ve had 10 or more hits this season — tied for 3rd lowest in MLB.

Guardians Keys to the Game vs. the White Sox

The Guardians are 32-18 (.640) when tied entering the 8th inning since the 2024 season — 2nd best in MLB.

The Guardians were 82-0 (1.000) when leading entering the 9th inning in the 2024 season — best in MLB; League Avg: .949.

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians are 191-12 (.941) when leading entering the 7th inning since the 2024 season — best in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have 69 extra-base hits out of 144 total hits (48%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The White Sox are batting just .228 on the road this season — tied for 2nd lowest in MLB.

White Sox hitters have struck out in 24% of their PA’s against RHP this season — 5th highest in MLB.

The White Sox are 45-19 (.703) against the run line (25.9% ROI) vs bottom 10 scoring offenses this season Today, they face the Guardians (27th in runs scored).

Guardians Hitting Stats & Trends

Guardians hitters have an OPS of just .652 (1,794 PA’s) in innings 7-9 this season — lowest in MLB.

Guardians hitters have a Hard-Hit Rate of just 35% against RHP this season — lowest in MLB.

Guardians hitters are slugging just .375 this season — 2nd lowest in MLB.

Guardians hitters are slugging just .386 against RHP this season — 5th lowest in MLB.

White Sox Pitching Stats & Trends

Opponents have a groundball rate of just 40% against White Sox pitchers this season — tied for 4th lowest in MLB.

White Sox pitchers have an ERA of 3.19 (392.0 IP) against division opponents this season — 2nd best in MLB.

The White Sox have won 47% of home games in which their opponents scored first this season — 2nd highest in MLB.

White Sox pitchers have allowed an OBP of .337 (1,345 PA’s) when facing the leadoff batter in the inning this season — 5th highest in MLB.

Guardians Pitching Stats & Trends

Guardians pitchers have a strikeout rate of 30% in close and late situations this season — best in MLB.

Guardians pitchers have induced opposing hitters to ground into just 78 double plays in 1,100 opportunities (7%) this season — lowest in MLB.

Guardians pitchers have a strikeout rate of 46% with two-strikes this season — 4th best in MLB.

Guardians pitchers have a strikeout rate of 25% this season — tied for 3rd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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