• The Mariners are -155 favorites vs the White Sox
• White Sox vs Mariners Over / Under today: 7.5 Runs
• White Sox / Mariners TV Channel: CHSN | MRTV

The Chicago White Sox (+125) visit T-Mobile Park to take on the Seattle Mariners (-155) on May 20, 2026. First pitch is scheduled for 4:10 pm in Seattle, WA.

This season, the White Sox are 25-23 against the spread (ATS), while the Mariners are 18-32 ATS.

White Sox vs Mariners Starting Pitchers Today:

• White Sox starting pitcher: Sean Burke 2-3, 4.07 ERA
• Mariners starting pitcher: Emerson Hancock 3-2, 3.06 ERA

White Sox vs. Mariners Odds, Run Line, Over/Under & Moneyline

White Sox vs Mariners Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Wednesday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on White Sox vs Mariners and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Tristan Peters has hit the Home Runs Over in 2 of his last 4 games (+17.00 Units / 425% ROI)
• Chase Meidroth has hit the Runs Over in 16 of his last 25 games (+14.95 Units / 60% ROI)
• Colson Montgomery has hit the Singles Under in 17 of his last 20 away games (+11.55 Units / 33% ROI)
• Chase Meidroth has hit the Hits Runs and RBIs Over in his last 10 away games (+11.45 Units / 107% ROI)
• Chase Meidroth has hit the Hits Over in 20 of his last 25 games (+11.40 Units / 24% ROI)

And here are some favorite MLB player prop bets for Mariners players for Wednesday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Best Bets Today:

• J.P. Crawford has hit the Home Runs Over in 3 of his last 7 games at home (+21.50 Units / 307% ROI)
• Cole Young has hit the Runs Under in 22 of his last 25 games (+15.05 Units / 28% ROI)
• Cole Young has hit the Singles Over in 15 of his last 25 games at home (+11.55 Units / 46% ROI)
• Mitch Garver has hit the Walks Over in 8 of his last 10 games (+9.25 Units / 92% ROI)
• Julio Rodriguez has hit the Hits Over in 14 of his last 20 games at home (+7.60 Units / 20% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Moneyline in 19 of their last 30 games (+10.25 Units / 33% ROI)
• The Chicago White Sox have covered the Run Line in 15 of their last 20 games (+9.40 Units / 31% ROI)
• The Chicago White Sox have hit the Team Total Over in 20 of their last 30 games (+8.95 Units / 26% ROI)
• The Chicago White Sox have hit the Game Total Over in 28 of their last 50 games (+5.20 Units / 10% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 8 of their last 11 games (+4.85 Units / 36% ROI)

Mariners Best Bets Today:

• The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 25 games (+7.75 Units / 24% ROI)
• The Seattle Mariners have hit the Team Total Under in 11 of their last 17 games (+4.95 Units / 27% ROI)
• The Seattle Mariners have covered the 1st Five Innings (F5) Run Line in 9 of their last 13 games (+4.65 Units / 32% ROI)
• The Seattle Mariners have hit the Game Total Under in 10 of their last 17 games (+3.35 Units / 18% ROI)
• The Seattle Mariners have hit the 1st Five Innings (F5) Moneyline in 9 of their last 13 games (+2.85 Units / 14% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 27-20 against the Run Line (-1.15 Units / -1.63% ROI).

• 25-23 when betting on the Moneyline for +6.75 Units / 13.61% ROI
• 27-20 when betting on the total runs Over for +5.2 Units / 9.9% ROI
• 20-27 when betting on the total runs Under for -9.85 Units / -18.55% ROI

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 18-32 against the Run Line (-10.45 Units / -19.75% ROI).

• 23-27 when betting on the Moneyline for -13.75 Units / -19.42% ROI
• 22-26 when betting on the total runs Over for -6.75 Units / -12.18% ROI
• 26-22 when betting on the total runs Under for +1.9 Units / 3.47% ROI

Mariners vs White Sox Home Run Prop Bets Today

Mariners vs White Sox Total Hits Prop Bets Today

Mariners vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Mariners

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

The White Sox are just 63-18 (.778) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .873.

The White Sox are just 24-107 (.183) when scoring 4 or fewer runs since the 2025 season — 2nd lowest in MLB; League Avg: .284.

The White Sox were just 41-121 (.253) in the 2024 season — lowest in MLB; League Avg: .500.

Mariners Keys to the Game vs. the White Sox

The Mariners are just 17-4 (.810) when leading entering the 8th inning this season — 2nd lowest in MLB; League Avg: .896.

The Mariners are just 6-23 (.207) when scoring 4 or fewer runs this season — 5th lowest in MLB; League Avg: .278.

The Mariners are 10-74 (.119) when trailing entering the 8th inning since the 2025 season — 5th best in MLB; League Avg: .093.

The Mariners are 23-15 (.605) when tied entering the 7th inning since the 2025 season — 5th best in MLB; League Avg: .500.

White Sox Hitting Stats & Trends

White Sox hitters are slugging .711 on the first pitch of at-bats this season — best in MLB.

The White Sox are batting just .206 on pitches 95 mph or greater this season — lowest in MLB.

White Sox hitters have an OPS of .780 (492 PA’s) against LHP this season — 4th best in MLB.

White Sox hitters have struck out in 24% of their PA’s this season — 4th highest in MLB.

Mariners Hitting Stats & Trends

The Mariners are batting just .188 against LHP this season — lowest in MLB.

Mariners hitters have an OBP of just .276 (557 PA’s) against LHP this season — lowest in MLB.

The Mariners are batting just .264 on the first pitch of at-bats this season — lowest in MLB.

Mariners hitters have an OPS of just .588 (557 PA’s) against LHP this season — 3rd lowest in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a miss rate of just 23% against White Sox pitchers this season — 4th lowest in MLB.

White Sox pitchers have walked 11% of batters this season — 5th highest in MLB.

White Sox pitchers have a strikeout rate of just 39% with two-strikes this season — 5th lowest in MLB.

Mariners Pitching Stats & Trends

Mariners pitchers have a first-pitch strike rate of 67% this season — highest in MLB.

Mariners pitchers have walked 7% of batters this season — best in MLB.

Mariners pitchers have thrown at least two strikes in their first three pitches to 71% of opposing batters this season — highest in MLB.

Mariners pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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