• The Padres are -145 favorites vs the White Sox
• White Sox vs Padres Over / Under today: 8 Runs
• White Sox / Padres TV Channel: CHSN | PDTV

The Chicago White Sox (+120) visit Petco Park to take on the San Diego Padres (-145) on May 1, 2026. First pitch is scheduled for 9:40 pm in San Diego, CA.

This season, the White Sox are 14-17 against the spread (ATS), while the Padres are 18-11 ATS.

White Sox vs Padres Starting Pitchers Today:

• White Sox starting pitcher: Noah Schultz 1-1, 3.45 ERA
• Padres starting pitcher: German Marquez 3-1, 4.44 ERA

White Sox vs. Padres Odds, Run Line, Over/Under & Moneyline

White Sox vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Friday‘s MLB game with 57.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on White Sox vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Colson Montgomery has hit the Home Runs Over in 5 of his last 7 away games (+20.30 Units / 290% ROI)
• Miguel Vargas has hit the Walks Over in 17 of his last 25 games (+14.10 Units / 56% ROI)
• Edgar Quero has hit the Runs Under in 14 of his last 15 games (+12.00 Units / 37% ROI)
• Luisangel Acuna has hit the Hits Under in 11 of his last 15 games (+10.40 Units / 69% ROI)
• Luisangel Acuna has hit the Total Bases Under in 11 of his last 15 games (+9.60 Units / 60% ROI)

And here are some favorite MLB player prop bets for Padres players for Friday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Xander Bogaerts has hit the Home Runs Over in 3 of his last 9 games at home (+16.50 Units / 183% ROI)
• Jackson Merrill has hit the Total Bases Under in his last 10 games (+10.15 Units / 77% ROI)
• Jackson Merrill has hit the Runs Over in 16 of his last 25 games at home (+10.05 Units / 39% ROI)
• Jackson Merrill has hit the Hits Under in 13 of his last 20 games (+9.95 Units / 36% ROI)
• Fernando Tatis Jr. has hit the Singles Over in 15 of his last 20 games (+8.80 Units / 35% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 31 of their last 50 away games (+10.70 Units / 19% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 31 of their last 50 away games (+8.20 Units / 13% ROI)
• The Chicago White Sox have hit the Game Total Over in 29 of their last 50 away games (+7.15 Units / 13% ROI)
• The Chicago White Sox have hit the Moneyline in 5 of their last 7 away games (+4.75 Units / 68% ROI)
• The Chicago White Sox have covered the Run Line in 6 of their last 7 away games (+4.40 Units / 41% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the Run Line in 31 of their last 50 games at home (+14.40 Units / 23% ROI)
• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 games at home (+11.70 Units / 20% ROI)
• The San Diego Padres have hit the Moneyline in 26 of their last 40 games (+10.80 Units / 21% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 24 of their last 40 games at home (+9.35 Units / 16% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Team Total Over in 16 of their last 24 games at home (+7.85 Units / 27% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 15-16 against the Run Line (-7.55 Units / -16.91% ROI).

• 14-17 when betting on the Moneyline for +0.2 Units / 0.62% ROI
• 18-13 when betting on the total runs Over for +3.9 Units / 11.52% ROI
• 13-18 when betting on the total runs Under for -6.85 Units / -19.94% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 18-11 against the Run Line (+4.65 Units / 11.22% ROI).

• 19-11 when betting on the Moneyline for +7.15 Units / 18.92% ROI
• 14-14 when betting on the total runs Over for -1.15 Units / -3.5% ROI
• 14-14 when betting on the total runs Under for -1.3 Units / -3.92% ROI

Padres vs White Sox Home Run Prop Bets Today

Padres vs White Sox Total Hits Prop Bets Today

Padres vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Padres

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

The White Sox are just 66-7 (.904) when leading entering the 9th inning since the 2025 season — lowest in MLB; League Avg: .954.

The White Sox are just 56-18 (.757) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .871.

The White Sox are just 74-119 (.383) since the 2025 season — 2nd lowest in MLB; League Avg: .500.

Padres Keys to the Game vs. the White Sox

The Padres are 14-1 (.933) when allowing 4 or fewer runs this season — 2nd best in MLB; League Avg: .730.

The Padres are 2-11 (.154) when trailing entering the 9th inning this season — tied for 4th best in MLB; League Avg: .059.

The Padres are 19-12 (.613) when tied entering the 7th inning since the 2025 season — tied for 4th best in MLB; League Avg: .500.

The Padres are 7-3 (.700) after a loss this season — tied for 5th best in MLB; League Avg: .477.

White Sox Hitting Stats & Trends

White Sox hitters have a groundball batting average of just .220 with runners on base since the 2025 season — lowest in MLB.

White Sox hitters are slugging just .363 against RHP since the 2025 season — 2nd lowest in MLB.

The White Sox have a winning percentage of just 29% on the road since the 2024 season — 2nd lowest in MLB.

The White Sox are batting just .207 with runners on base this season — 2nd lowest in MLB.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

Padres hitters have a swing rate of 63% with two-strikes since the 2025 season — highest in MLB.

Padres hitters have struck out in just 20% of their PA’s since the 2025 season — 3rd best in MLB.

Padres hitters have an OBP of just .309 (1,123 PA’s) this season — tied for 5th lowest in MLB.

White Sox Pitching Stats & Trends

White Sox pitchers have walked 13% of batters when facing the leadoff batter in the inning this season — highest in MLB.

White Sox pitchers have walked 10% of batters when facing the leadoff batter in the inning since the 2025 season — 3rd highest in MLB.

White Sox pitchers have a strikeout rate of just 38% with two-strikes this season — 3rd lowest in MLB.

Opponents have a miss rate of just 22% against White Sox pitchers this season — 3rd lowest in MLB.

Padres Pitching Stats & Trends

Opponents have a groundball rate of 48% against Padres pitchers this season — 2nd highest in MLB.

Opponents have a groundball rate of 54% against Padres pitchers over the past seven days (5 games) — highest in MLB.

The Padres have allowed 3.54 runs per game (343/97) at home since the 2025 season — 2nd best in MLB.

Padres pitchers have an ERA of 3.27 (885.0 IP) at home since the 2025 season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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