• The Padres are -190 favorites vs the White Sox
• White Sox vs Padres Over / Under today: 8.5 Runs
• White Sox / Padres TV Channel: CHSN | PDTV

The Chicago White Sox (+155) visit Petco Park to take on the San Diego Padres (-190) on May 3, 2026. First pitch is scheduled for 4:10 pm in San Diego, CA.

This season, the White Sox are 16-17 against the spread (ATS), while the Padres are 18-13 ATS.

White Sox vs Padres Starting Pitchers Today:

• White Sox starting pitcher: Anthony Kay 1-1, 6.05 ERA
• Padres starting pitcher: Griffin Canning 0-0, 0.00 ERA

White Sox vs. Padres Odds, Run Line, Over/Under & Moneyline

White Sox vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Sunday‘s MLB game with 62.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on White Sox vs Padres and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for White Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Colson Montgomery has hit the Home Runs Over in 6 of his last 9 away games (+23.00 Units / 256% ROI)
• Chase Meidroth has hit the Runs Over in 15 of his last 25 games (+12.50 Units / 50% ROI)
• Chase Meidroth has hit the Hits Over in 14 of his last 15 games (+12.50 Units / 43% ROI)
• Miguel Vargas has hit the Walks Over in 16 of his last 25 games (+11.80 Units / 47% ROI)
• Colson Montgomery has hit the RBIs Over in 7 of his last 9 away games (+9.55 Units / 106% ROI)

And here are some favorite MLB player prop bets for Padres players for Sunday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

• Xander Bogaerts has hit the Home Runs Over in 2 of his last 7 games at home (+10.00 Units / 143% ROI)
• Fernando Tatis Jr. has hit the Singles Over in 15 of his last 20 games (+8.70 Units / 35% ROI)
• Nick Castellanos has hit the Runs Under in 13 of his last 15 games (+8.65 Units / 28% ROI)
• Ramon Laureano has hit the Total Bases Under in 9 of his last 10 games (+8.20 Units / 59% ROI)
• Ramon Laureano has hit the Hits Over in 12 of his last 15 games at home (+7.40 Units / 26% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Team Total Over in 31 of their last 50 away games (+10.75 Units / 19% ROI)
• The Chicago White Sox have hit the Moneyline in 7 of their last 9 away games (+7.50 Units / 83% ROI)
• The Chicago White Sox have covered the Run Line in 8 of their last 9 away games (+6.40 Units / 46% ROI)
• The Chicago White Sox have hit the Game Total Over in 14 of their last 21 away games (+6.35 Units / 27% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 30 of their last 50 away games (+6.05 Units / 9% ROI)

Padres Best Bets Today:

• The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 games at home (+11.85 Units / 20% ROI)
• The San Diego Padres have covered the Run Line in 17 of their last 25 games at home (+11.05 Units / 33% ROI)
• The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 29 of their last 50 games at home (+9.85 Units / 13% ROI)
• The San Diego Padres have hit the Team Total Under in 11 of their last 13 games (+8.95 Units / 62% ROI)
• The San Diego Padres have hit the Moneyline in 17 of their last 25 games (+7.45 Units / 23% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 17-16 against the Run Line (-5.55 Units / -11.61% ROI).

• 16-17 when betting on the Moneyline for +2.95 Units / 8.64% ROI
• 19-14 when betting on the total runs Over for +3.8 Units / 10.53% ROI
• 14-19 when betting on the total runs Under for -6.9 Units / -18.9% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 18-13 against the Run Line (+2.65 Units / 6.1% ROI).

• 19-13 when betting on the Moneyline for +3.95 Units / 9.63% ROI
• 15-15 when betting on the total runs Over for -1.25 Units / -3.56% ROI
• 15-15 when betting on the total runs Under for -1.35 Units / -3.82% ROI

Padres vs White Sox Home Run Prop Bets Today

Padres vs White Sox Total Hits Prop Bets Today

Padres vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Padres

The White Sox are just 91-41 (.689) when leading entering the 7th inning since the 2024 season — lowest in MLB; League Avg: .864.

The White Sox are just 58-18 (.763) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .871.

The White Sox are just 73-101 (.420) when allowing 5 or more extra base hits since the 2025 season — 2nd lowest in MLB; League Avg: .534.

The White Sox are just 68-7 (.907) when leading entering the 9th inning since the 2025 season — lowest in MLB; League Avg: .954.

Padres Keys to the Game vs. the White Sox

The Padres are 14-2 (.875) when allowing 4 or fewer runs this season — 5th best in MLB; League Avg: .728.

The Padres are 76-7 (.916) when leading entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .871.

The Padres are 14-66 (.175) when trailing entering the 7th inning since the 2025 season — 3rd best in MLB; League Avg: .128.

The Padres are 47-37 (.560) after a loss since the 2025 season — 3rd best in MLB; League Avg: .481.

White Sox Hitting Stats & Trends

White Sox hitters are slugging just .364 against RHP since the 2025 season — 2nd lowest in MLB.

White Sox hitters have a groundball batting average of just .220 with runners on base since the 2025 season — lowest in MLB.

The White Sox are batting just .150 against division opponents this season — lowest in MLB.

The White Sox won only 25% of games in the 2024 season — lowest in MLB.

Padres Hitting Stats & Trends

Padres hitters have struck out in just 19% of their PA’s against LHP since the 2025 season — 2nd best in MLB.

Padres hitters have an OPS of just .614 (649 PA’s) against starting pitchers this season — lowest in MLB.

Padres hitters have an OPS of just .598 (224 PA’s) against LHP this season — 3rd lowest in MLB.

The Padres are batting .398 on the first pitch of at-bats this season — 2nd best in MLB.

White Sox Pitching Stats & Trends

Opponents have a miss rate of just 22% against White Sox pitchers this season — 4th lowest in MLB.

White Sox pitchers have walked 10% of batters since the 2025 season — 2nd highest in MLB.

White Sox pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — tied for highest in MLB.

White Sox pitchers have walked 2% of batters when facing the leadoff batter in the inning over the past seven days (6 games) — best in MLB.

Padres Pitching Stats & Trends

Padres pitchers have walked 17% of batters when facing the leadoff batter in the inning over the past seven days (6 games) — highest in MLB.

Opponents have a groundball rate of 47% against Padres pitchers this season — 2nd highest in MLB.

Opponents have a miss rate of 27% against Padres pitchers this season — 5th best in MLB.

Padres pitchers have induced opposing hitters to ground into 25 double plays in 226 opportunities (11%) this season — 4th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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