• The Red Sox are -125 favorites vs the White Sox
• White Sox vs Red Sox Over / Under today: 8.5 Runs
• White Sox / Red Sox TV Channel: NESN | CHSN

The Chicago White Sox (+105) visit Fenway Park to take on the Boston Red Sox (-125) on August 5, 2026. First pitch is scheduled for 7:10 pm in Boston, MA.

This season, the White Sox are 59-53 against the spread (ATS), while the Red Sox are 56-52 ATS.

White Sox vs Red Sox Starting Pitchers Today:

• White Sox starting pitcher: Sean Burke 7-5, 3.04 ERA
• Red Sox starting pitcher: Sonny Gray 13-2, 2.96 ERA

White Sox vs. Red Sox Odds, Run Line, Over/Under & Moneyline

White Sox vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Wednesday‘s MLB game with 51.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

• Chase Meidroth has hit the Home Runs Over in 2 of his last 9 games (+15.00 Units / 167% ROI)
• Drew Romo has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+14.60 Units / 50% ROI)
• Munetaka Murakami has hit the Total Bases Over in 18 of his last 25 games (+12.15 Units / 40% ROI)
• Munetaka Murakami has hit the Hits Over in 20 of his last 25 games (+11.40 Units / 28% ROI)
• Miguel Vargas has hit the Singles Under in 16 of his last 20 away games (+10.15 Units / 36% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

• Ceddanne Rafaela has hit the Home Runs Over in 4 of his last 8 games (+23.10 Units / 289% ROI)
• Andruw Monasterio has hit the Total Bases Over in 20 of his last 25 games (+15.35 Units / 45% ROI)
• Andruw Monasterio has hit the Hits Runs and RBIs Over in 17 of his last 20 games (+14.90 Units / 62% ROI)
• Andruw Monasterio has hit the Hits Over in 18 of his last 20 games (+14.25 Units / 44% ROI)
• Willson Contreras has hit the Runs Over in 17 of his last 25 games at home (+9.75 Units / 37% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have covered the Run Line in 24 of their last 40 games (+9.00 Units / 16% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 15 of their last 21 away games (+8.00 Units / 32% ROI)
• The Chicago White Sox have hit the Team Total Over in 29 of their last 50 away games (+6.15 Units / 11% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 21 of their last 35 away games (+5.75 Units / 14% ROI)
• The Chicago White Sox have hit the Moneyline in 8 of their last 12 away games (+5.15 Units / 41% ROI)

Red Sox Best Bets Today:

• The Boston Red Sox have hit the Moneyline in 32 of their last 40 games (+23.25 Units / 45% ROI)
• The Boston Red Sox have covered the Run Line in 24 of their last 35 games (+18.20 Units / 43% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 35 games (+14.40 Units / 35% ROI)
• The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 26 of their last 40 games (+14.10 Units / 27% ROI)
• The Boston Red Sox have hit the Team Total Over in 25 of their last 35 games (+13.50 Units / 32% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 64-45 against the Run Line (+6.3 Units / 3.94% ROI).

• 59-53 when betting on the Moneyline for +13.35 Units / 11.13% ROI
• 63-47 when betting on the total runs Over for +11.65 Units / 9.51% ROI
• 47-63 when betting on the total runs Under for -22.65 Units / -18.29% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 56-52 against the Run Line (+5.3 Units / 3.76% ROI).

• 61-51 when betting on the Moneyline for +0.4 Units / 0.29% ROI
• 49-59 when betting on the total runs Over for -16.6 Units / -13.39% ROI
• 59-49 when betting on the total runs Under for +5.1 Units / 4.16% ROI

White Sox Keys to the Game vs. the Red Sox

The White Sox are just 5-26 (.161) when allowing 10 or more hits this season — 4th lowest in MLB.

The White Sox are 9-5 (.643) when tied entering the 8th inning this season — 4th best in MLB.

The White Sox are 10-4 (.714) when tied entering the 7th inning this season — 3rd best in MLB.

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

Red Sox Keys to the Game vs. the White Sox

The Red Sox are 36-24 (.600) after a win this season — 3rd best in MLB.

The Red Sox are 54-1 (.982) when leading entering the 8th inning this season — tied for best in MLB.

The Red Sox are 26-18 (.591) vs the top 10 runs allowed teams this season Today, they face White Sox (11th in runs allowed).

The Red Sox are just 4-7 (.364) when tied entering the 8th inning this season — 5th lowest in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have 55 extra-base hits out of 113 total hits (49%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The White Sox have a winning percentage of 62% at home this season — 4th best in MLB.

White Sox hitters are slugging .621 on the first pitch of at-bats this season — 2nd best in MLB.

White Sox hitters have grounded into 50 double plays in 794 opportunities (6%) this season — best in MLB.

Red Sox Hitting Stats & Trends

The Red Sox are batting .262 against LHP this season — 3rd best in MLB.

Red Sox hitters have an OPS of .780 (1,125 PA’s) against LHP this season — 3rd best in MLB.

Red Sox hitters are slugging .440 against LHP this season — 2nd best in MLB.

Red Sox hitters are slugging .254 on pitches out of the zone this season — 2nd best in MLB.

White Sox Pitching Stats & Trends

The White Sox have won 53% of home games in which their opponents scored first this season — 2nd highest in MLB.

White Sox pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — tied for 3rd highest in MLB.

White Sox pitchers have an ERA of 4.91 (486.0 IP) on the road this season — 5th highest in MLB.

White Sox pitchers have an ERA of 3.30 (510.0 IP) at home this season — 4th best in MLB.

Red Sox Pitching Stats & Trends

Red Sox pitchers have walked 8% of batters this season — 3rd best in MLB.

Red Sox pitchers have an ERA of 3.37 (496.1 IP) on the road this season — 2nd best in MLB.

Red Sox pitchers have a strikeout rate of 45% with two-strikes this season — tied for 4th best in MLB.

Red Sox pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — 5th best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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