• The Yankees are -155 favorites vs the Twins
• Yankees vs Twins Over / Under today: 8 Runs
• Yankees / Twins TV Channel: TWTV | YES

The New York Yankees (-155) visit Target Field to take on the Minnesota Twins (+125) on September 16, 2026. First pitch is scheduled for 1:40 pm in Minneapolis, MN.

This season, the Yankees are 88-63 against the spread (ATS), while the Twins are 78-71 ATS.

Yankees vs Twins Starting Pitchers Today:

• Yankees starting pitcher: Carlos Rodon 6-3, 2.93 ERA
• Twins starting pitcher: Zebby Matthews 9-10, 5.02 ERA

Yankees vs. Twins Odds, Run Line, Over/Under & Moneyline

Yankees vs Twins Prediction for Today’s Game

Based on recent trends the model predicts the Yankees will win Wednesday‘s MLB game with 58.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Yankees players for Wednesday‘s game, looking at profitable historical betting trends:

Best Yankees Player Prop Bets Today:

• Heliot Ramos has hit the Runs Under in 22 of his last 25 games (+16.90 Units / 38% ROI)
• Heliot Ramos has hit the Hits Runs and RBIs Under in 21 of his last 25 games (+16.25 Units / 51% ROI)
• Cody Bellinger has hit the Home Runs Over in 4 of his last 7 games (+15.80 Units / 226% ROI)
• Spencer Jones has hit the Total Bases Over in 20 of his last 25 games (+14.40 Units / 43% ROI)
• Spencer Jones has hit the Hits Over in 20 of his last 25 games (+12.90 Units / 35% ROI)

And here are some favorite MLB player prop bets for Twins players for Wednesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Best Bets Today:

• Royce Lewis has hit the Runs Under in 22 of his last 25 games (+16.00 Units / 37% ROI)
• Austin Martin has hit the Singles Under in 13 of his last 15 games (+10.65 Units / 55% ROI)
• Austin Martin has hit the Hits Runs and RBIs Under in 18 of his last 25 games at home (+10.15 Units / 35% ROI)
• Royce Lewis has hit the Total Bases Under in 17 of his last 25 games (+9.90 Units / 31% ROI)
• Ryan Jeffers has hit the Home Runs Over in 2 of his last 6 games at home (+8.10 Units / 135% ROI)

Yankees Best Bets Today:

• The New York Yankees have covered the Run Line in 23 of their last 35 games (+16.35 Units / 40% ROI)
• The New York Yankees have hit the Moneyline in 32 of their last 50 away games (+11.40 Units / 18% ROI)
• The New York Yankees have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+11.00 Units / 14% ROI)
• The New York Yankees have covered the 1st Five Innings (F5) Run Line in 14 of their last 20 away games (+8.10 Units / 35% ROI)
• The New York Yankees have hit the Game Total Under in 24 of their last 40 away games (+7.55 Units / 17% ROI)

Twins Best Bets Today:

• The Minnesota Twins have hit the Game Total Over in 16 of their last 24 games (+8.15 Units / 30% ROI)
• The Minnesota Twins have hit the Team Total Under in 30 of their last 50 games (+7.05 Units / 12% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 12 games (+5.80 Units / 39% ROI)
• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 9 of their last 15 games at home (+3.20 Units / 19% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 9 of their last 15 games at home (+3.20 Units / 18% ROI)

Yankees Against the Spread (ATS) Record

Against the spread this season, the Yankees are 77-73 against the Run Line (+13.4 Units / 7.82% ROI).

• 88-63 when betting on the Moneyline for -0.55 Units / -0.25% ROI
• 67-79 when betting on the total runs Over for -20.3 Units / -12.18% ROI
• 79-67 when betting on the total runs Under for +5.55 Units / 3.35% ROI

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 78-71 against the Run Line (-12.3 Units / -5.72% ROI).

• 70-81 when betting on the Moneyline for -10.9 Units / -6.45% ROI
• 82-60 when betting on the total runs Over for +15.1 Units / 9.03% ROI
• 60-82 when betting on the total runs Under for -30.1 Units / -18.23% ROI

Yankees Keys to the Game vs. the Twins

The Yankees are 52-6 (.897) when they’ve hit 2 or more home runs this season — best in MLB.

The Yankees are 38-4 (.905) when they’ve had 10 or more hits this season — best in MLB.

The Yankees are 57-6 (.905) when scoring 5 or more runs this season — best in MLB.

The Yankees are 78-1 (.987) when leading entering the 9th inning this season — tied for 5th best in MLB.

Twins Keys to the Game vs. the Yankees

The Twins are just 14-9 (.609) when they’ve had 5 or more XBH this season — 2nd lowest in MLB.

The Twins are just 26-22 (.542) when they’ve hit 2 or more home runs this season — 2nd lowest in MLB.

The Twins are just 4-65 (.058) when trailing entering the 8th inning this season — 5th lowest in MLB.

The Twins are just 5-11 (.312) when tied entering the 7th inning this season — 4th lowest in MLB.

Yankees Hitting Stats & Trends

Yankees hitters have an OPS of .777 (1,805 PA’s) in innings 7-9 this season — best in MLB.

The Yankees have a winning percentage of 60% on the road this season — best in MLB.

The Yankees are 52-6 (.897) when they’ve hit 2 or more home runs this season — best in MLB.

The Yankees are batting just .127 on pitches out of the zone this season — tied for lowest in MLB.

Twins Hitting Stats & Trends

The Twins are batting just .303 on the first pitch of at-bats this season — tied for lowest in MLB.

Twins hitters have struck out in just 20% of their PA’s against RHP this season — tied for 4th best in MLB.

Twins hitters are slugging just .360 against LHP this season — 4th lowest in MLB.

Twins hitters are slugging .423 against RHP this season — tied for 3rd best in MLB.

Yankees Pitching Stats & Trends

Yankees pitchers have an ERA of 2.90 (679.0 IP) on the road this season — best in MLB.

Yankees pitchers have an ERA of 3.21 (1350.0 IP) this season — best in MLB.

Yankees pitchers have an ERA of 2.80 (394.2 IP) against division opponents this season — best in MLB.

Opponents have a groundball rate of 45% against Yankees pitchers this season — 5th highest in MLB.

Twins Pitching Stats & Trends

Opponents have a groundball rate of just 40% against Twins pitchers this season — 3rd lowest in MLB.

Twins pitchers have walked 10% of batters when facing the leadoff batter in the inning this season — tied for 2nd highest in MLB.

Twins pitchers have an ERA of 5.22 (633.0 IP) on the road this season — 3rd highest in MLB.

Twins pitchers have allowed opponents to score in three different innings in 52% of their games this season — 5th highest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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