Cavaliers vs Knicks Prediction, Odds, Best Bets & Team Props – NBA, May 21

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  • The Knicks are -6.5 favorites vs. the Cavaliers
  • Total (Over/Under): 216.5 points
  • Watch the game on ESPN

The Cleveland Cavaliers visit Madison Square Garden to take on the New York Knicks on Thursday. Tipoff is scheduled for 8:00 pm in New York, NY.

The Knicks are betting favorites in this NBA matchup, with the spread sitting at -6.5 (-110).

The Cavaliers vs Knicks Over/Under is 216.5 total points for the game.

So far this NBA season, the Cavaliers are 39-55 against the spread, while the Knicks are 50-40 against the spread.


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Cavaliers vs. Knicks Odds, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cleveland Cavaliers+6.5 -110O 216.5 -110+200
New York Knicks -6.5 -110U 216.5 -110-250

Knicks vs Cavaliers Prediction for Tonight’s Game:

The winning team model predicts the Knicks will win Thursday‘s game with 65.5% confidence, factoring in game simulations, player injuries, key player performances and recent matchups for both Cavaliers and Knicks.

Knicks vs Cavaliers Spread Prediction:

Based on recent against-the-spread (ATS) trends, the model predicts the Cavaliers will cover the spread for Thursday‘s game with 60.5% confidence.


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  • The Cleveland Cavaliers have hit the 4Q Moneyline in 31 of their last 45 away games (+15.20 Units / 25% ROI)
  • The Cleveland Cavaliers have covered the 4Q Spread in 31 of their last 45 away games (+14.60 Units / 28% ROI)
  • The Cleveland Cavaliers have hit the 1Q Game Total Over in 27 of their last 40 games (+13.00 Units / 28% ROI)
  • The Cleveland Cavaliers have hit the 3Q Game Total Over in 31 of their last 50 games (+10.00 Units / 17% ROI)
  • The Cleveland Cavaliers have hit the Team Total Under in 12 of their last 15 away games (+8.60 Units / 51% ROI)
  • The New York Knicks have hit the 4Q Moneyline in 35 of their last 50 games (+19.80 Units / 27% ROI)
  • The New York Knicks have covered the Spread in 31 of their last 45 games at home (+16.70 Units / 34% ROI)
  • The New York Knicks have hit the Moneyline in 26 of their last 35 games (+15.40 Units / 10% ROI)
  • The New York Knicks have covered the 4Q Spread in 23 of their last 30 games at home (+14.80 Units / 43% ROI)
  • The New York Knicks have hit the 2H Moneyline in 36 of their last 50 games (+13.97 Units / 15% ROI)

Against the spread this NBA season, the Cavaliers have gone 39-55 (-21.5 Units / -20.36% ROI).

  • 60-36 against the Moneyline (-10.85 Units / -3.4% ROI)
  • 50-46 against the Over for game total points (-0.6 Units / -0.57% ROI)
  • 46-50 against the Under for game total points (-9 Units / -8.52% ROI)

Against the spread this NBA season, the Knicks have gone 50-40 (+6 Units / 5.99% ROI).

  • 61-30 against the Moneyline (+10.9 Units / 3.51% ROI)
  • 43-48 against the Over for game total points (-9.8 Units / -9.79% ROI)
  • 48-43 against the Under for game total points (+0.7 Units / 0.7% ROI)
  • The New York Knicks have only hit the 1H Moneyline in 27 of their last 50 games (-24.45 Units / -19% ROI)
  • The New York Knicks have only hit the 4Q Game Total Over in 16 of their last 45 games at home (-17.35 Units / -33% ROI)
  • The New York Knicks have only hit the 2Q Moneyline in 23 of their last 45 games at home (-15.35 Units / -18% ROI)
  • The New York Knicks have only hit the 2H Game Total Over in 20 of their last 50 games (-14.76 Units / -26% ROI)
  • The New York Knicks have only hit the Game Total Over in 20 of their last 50 games (-13.00 Units / -24% ROI)
  • The Cleveland Cavaliers have only hit the 1H Moneyline in 12 of their last 30 games (-23.50 Units / -31% ROI)
  • The Cleveland Cavaliers have only hit the 1Q Game Total Under in 12 of their last 40 games (-18.90 Units / -41% ROI)
  • The Cleveland Cavaliers have only hit the 3Q Moneyline in 17 of their last 45 away games (-17.75 Units / -27% ROI)
  • The Cleveland Cavaliers have only covered the 1H Spread in 16 of their last 45 away games (-17.35 Units / -33% ROI)
  • The Cleveland Cavaliers have only hit the 3Q Game Total Under in 18 of their last 50 games (-17.20 Units / -30% ROI)

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Cleveland Cavaliers: Keys to the Game vs. the New York Knicks

The Cavaliers are 27-13 (.675) when scoring 15 or more second chance points this season — 7th best among NBA teams; League Avg: .542

The Cavaliers are 21-8 (.724) when scoring fewer than 10 second chance points since the start of the 2024-25 season — 2nd best among NBA teams; League Avg: .429

The Cavaliers are 21-12 (.636) when shooting 80% or better from the free throw line this season — 10th best among NBA teams; League Avg: .534

The Cavaliers are 9-4 (.692) when allowing fewer than 10 second chance points this season — 7th best among NBA teams; League Avg: .601

New York Knicks: Keys to the Game vs. the Cleveland Cavaliers

The Knicks are 22-1 (.957) when forcing an eFG of 50% or worse this season — best among NBA teams; League Avg: .787

The Knicks are 35-15 (.700) when scoring 15 or more fastbreak points this season — 9th best among NBA teams; League Avg: .572

The Knicks are 38-15 (.717) when winning the rebounding margin this season — tied for 9th best among NBA teams; League Avg: .659

The Knicks are 30-10 (.750) when shooting 80% or better from the free throw line this season — 5th best among NBA teams; League Avg: .534

Cleveland Cavaliers Offensive Stats & Trends

The Cavaliers have averaged 60.8 points per game (9,969 points/164 games) in the second half since the start of the 2024-25 season — best among NBA teams; League Avg: 56.7

The Cavaliers have averaged 119.5 points per game (9,801 points/82 games) this season — 4th best among NBA teams; League Avg: 115.6

The Cavaliers have an eFG% of 56% this season — tied for 4th best among NBA teams; League Avg: 55%

The Cavaliers have averaged 14.0 turnovers per game (1,147 turnovers/82 games) this season — 9th best among NBA teams; League Avg: 14.5

New York Knicks Offensive Stats & Trends

The Knicks have averaged 16.3 second chance points per game (1,335 points/82 games) this season — 7th best among NBA teams; League Avg: 15.0

The Knicks have 21.3 free throw attempts per game this season — 6th lowest among NBA teams; League Avg: 23.5

The Knicks have a TS% of 53% this season — 6th best among NBA teams; League Avg: 51%

The Knicks have averaged 116.5 points per game (9,549 points/82 games) this season — 10th best among NBA teams; League Avg: 115.6

Cleveland Cavaliers Defensive Stats & Trends

The Cavaliers have averaged 35.8 defensive rebounds per game (5,870 rebounds/164 games) since the start of the 2024-25 season — tied for 9th best among NBA teams; League Avg: 35.1

The Cavaliers have allowed opponents to shoot 37% from three (1,163/3,127) this season — tied for 4th highest among NBA defenses; League Avg: 36%

The Cavaliers have allowed opponents to shoot 46% (3,387/7,303) this season — 8th best among NBA defenses; League Avg: 47%

The Cavaliers have forced 15.3 turnovers per game (629 turnovers/41 games) on the road this season — 10th best among NBA defenses; League Avg: 14.4

New York Knicks Defensive Stats & Trends

The Knicks have averaged 3.9 blocks per game (646 blocks/164 games) since the start of the 2024-25 season — lowest among NBA teams; League Avg: 4.9

The Knicks have averaged 3.9 blocks per game (322 blocks/82 games) this season — 2nd lowest among NBA teams; League Avg: 4.8

The Knicks have averaged 4.0 blocks per game (331 blocks/83 games) on the road since the start of the 2024-25 season — 2nd lowest among NBA teams; League Avg: 4.7

The Knicks have allowed 43.3 points in the paint per game (3,554 points/82 games) this season — 3rd best among NBA defenses; League Avg: 49.8


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.