- The 49ers (1-1) are -1.5 point favorites vs the Broncos (1-1)
- Total (Over/Under): 44.5 points
- Watch the game on NBC
The San Francisco 49ers (1-1) visit Empower Field at Mile High to take on the Denver Broncos (1-1) on Sep. 25. Kickoff is scheduled for 8:20pm EDT in Denver.
The 49ers are betting favorites in Week 3, with the spread sitting at -1.5 (-110).
The 49ers vs. Broncos Over/Under is 44.5 total points for the game.
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49ers vs. Broncos Odds, Spread, Over/Under Week 3
| Spread | Total (O/U) | Moneyline | |
| San Francisco 49ers | -1.5 -110 | 44.5 -110 | -125 |
| Denver Broncos | +1.5 -110 | 44.5 -110 | +105 |
49ers vs. Broncos Prediction for Week 3
Based on recent trends, the winning team model predicts the Broncos will win this Week 3 game with 57.0% confidence.
49ers vs Broncos Spread Prediction for Week 3
Based on recent against-the-spread trends, the model predicts the Broncos will cover the spread this Week 3 with 55.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Broncos, plus offensive & defensive matchups, recent games and key player performances this season.
Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 3, looking at profitable historical betting trends:
Best Broncos Player Prop Best Bets Today
And here are some top NFL player prop bets for Broncos players for Week 3, looking at profitable historical betting trends:
First Touchdown Scorer Bet for Broncos vs 49ers
| Player Name | 1st TD Odds |
|---|---|
| Jeff Wilson | +700 |
| Javonte Williams | +800 |
| Deebo Samuel | +800 |
| Courtland Sutton | +900 |
| Brandon Aiyuk | +1100 |
Anytime Touchdown Scorer Bet for Broncos vs 49ers
| Player Name | Anytime TD Odds |
|---|---|
| Jeff Wilson | +100 |
| Javonte Williams | +115 |
| Deebo Samuel | +115 |
| Courtland Sutton | +130 |
| Brandon Aiyuk | +160 |
Receiving Props: Total Receiving Yards for Broncos vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Brandon Aiyuk | 49.5 -115 | 49.5 -115 |
| Deebo Samuel | 56.5 -110 | 56.5 -115 |
| Melvin Gordon | 8.5 -120 | 8.5 -110 |
| Albert Okwuegbunam | 26.5 -115 | 26.5 -115 |
| Courtland Sutton | 57.5 -110 | 57.5 -115 |
Rushing Props: Total Rushing Yards for Broncos vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Melvin Gordon | 38.5 -115 | 38.5 -110 |
| Javonte Williams | 49.5 -115 | 49.5 -110 |
| Russell Wilson | 8.5 -115 | 8.5 -115 |
| Jeff Wilson Jr. | 56.5 -115 | 56.5 -115 |
| Deebo Samuel | 30.5 -110 | 30.5 -115 |
49ers Betting Trends: ATS, Moneyline, Over/Under
Broncos Betting Trends: ATS, Moneyline, Over/Under
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 1-1 (-0.1 Units / -4.55% ROI).
- 49ers are 1-1 when betting on the Moneyline for -1.65 Units / -25.58% ROI
- 49ers are 0-2 when betting the Over for -2.2 Units / -100% ROI
- 49ers are 2-0 when betting the Under for +2 Units / ROI
Broncos Against the Spread (ATS) Record
Against the spread this NFL season, the Broncos have gone 0-2 (-2.2 Units / -100% ROI).
- Broncos are 1-1 when betting on the Moneyline for -1.75 Units / -22.44% ROI
- Broncos are 0-2 when betting the Over for -2.25 Units / -100% ROI
- Broncos are 2-0 when betting the Under for +2 Units / 93.02% ROI
San Francisco 49ers: Keys to the Game vs. the Denver Broncos
The 49ers are undefeated (7-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — tied for best in NFL; League Avg: .533.
The 49ers were 1-2 (.333) when the opposing team rushes more than 30 times last season — tied for 3rd-best in NFL; League Avg: .165.
The 49ers were undefeated (6-0) when the opposing team converts less than 55% of its red zone chances into touchdowns last season — tied for best in NFL; League Avg: .533.
The 49ers are undefeated (5-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since Week 7 of 2021 — tied for best in NFL; League Avg: .509.
Denver Broncos: Keys to the Game vs. the San Francisco 49ers
The Broncos were winless (0-7) when allowing 22 or more points last season — tied for worst in NFL; League Avg: .267.
The Broncos were winless (0-2) when committing 2 or more turnovers last season — tied for worst in NFL; League Avg: .259.
The Broncos were winless (0-5) when allowing 27 or more points last season — tied for worst in NFL; League Avg: .198.
The Broncos are winless (0-6) when the opposing team rushes more than 30 times since the 2021 season — tied for worst in NFL; League Avg: .172.
Additional Matchup Notes for San Francisco 49ers vs. Denver Broncos
The Broncos have been successful on just 40.7% of plays they have run since the 2020 season — fourth-worst in NFL. 49ers have allowed their opponents to be successful on just 40.6% of plays since the 2020 season — third-best in NFL.
The Broncos have gained at least 5 yards on just 39.8% of first down plays since the 2020 season — third-worst in NFL. The 49ers have allowed at least 5 yards on just 40.9% of first down plays since the 2020 season — tied for fourth-best in NFL.
The Broncos have thrown for just 3.8 yards per attempt on first down this season — second-worst in NFL. The 49ers have allowed just 4.6 yards per dropback on first down this season — fourth-best in NFL.
The 49ers have thrown for 348 passing yards in 2 games (just 174.0 YPG) this season — second-worst in NFL. The Broncos have allowed just 165.5 passing yards per game this season — fifth-best in NFL.
The 49ers have thrown the ball just 37.7% of the time this season — second-lowest in NFL. The Broncos have allowed just 5.0 yards per dropback this season — fifth-best in NFL.
San Francisco 49ers Offense: Important Stats for Week 3
The 49ers started 12 drives inside their own 10 yard line in the 2nd half last season — most in NFL.
The 49ers have thrown the ball 38% of the time (52 Pass Attempts/138 plays) this season — 2nd-lowest in NFL; League Avg: 55%.
The 49ers started 19 drives inside their own 20 yard line in the 4th quarter last season — most in NFL.
The 49ers have run the ball on 60% of plays (83 carries/138 plays) this season — 2nd-highest in NFL; League Avg: 40%.
Denver Broncos Offense: Important Stats for Week 3
The Broncos have committed 7 turnovers in the red zone since the 2021 season — most in NFL.
The Broncos have gone three and out on 5% of their drives this season — 2nd-best in NFL; League Avg: 19%.
The Broncos have scored 3.8 points per Red Zone drive since the 2021 season — tied for worst in NFL; League Avg: 4.4.
The Broncos started 9 drives inside their own 10 yard line last season — tied for 3rd-fewest in NFL.
San Francisco 49ers Defense: Important Stats for Week 3
The 49ers defense has not allowed any points in 2 games in the 1st half this season — best in NFL; League Avg: 9.7.
The 49ers defense allowed a passer rating of 124.4 when blitzing (102 Pass Attempts) last season — worst in NFL; League Avg: 91.5.
The 49ers defense has not allowed scores on any opponent drives in the 1st half this season — best in NFL; League Avg: 35%.
The 49ers defense sacked opposing QBs on 8% of pass attempts (48/593) last season — 3rd-best in NFL; League Avg: 6%.
Denver Broncos Defense: Important Stats for Week 3
The Broncos defense has allowed successful plays on 18% of plays in the 4th quarter this season — 2nd-best in NFL; League Avg: 42%.
The Broncos defense has allowed successful plays on 24% of plays in the 2nd half this season — best in NFL; League Avg: 43%.
The Broncos defense allowed just 6.9 points per game to opposing offenses (117 points / 17 games) in the 2nd half last season — 2nd-best in NFL; League Avg: 10.9.
The Broncos defense has allowed successful plays on 21% of pass attempts in the 2nd half this season — best in NFL; League Avg: 46%.
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