49ers vs Buccaneers Prediction, Odds & Best Prop Bets – NFL, Week 6

BetMGM Betting Oct 09, 2025, 5:48 AM

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FILE - a general view of Raymond James Stadium during an NFL football game between the Philadelphia Eagles and the Tampa Bay Buccaneers, Sunday, Sept. 29, 2024, in Tampa, Fla. (AP Photo/Doug Murray, FIle)

(AP Photo/Doug Murray)

The Buccaneers are -3 point favorites vs the 49ers
Total (Over/Under): 47.5 points
Watch this game on CBS

The San Francisco 49ers (4-1-0) visit Raymond James Stadium to take on the Tampa Bay Buccaneers (4-1-0) on Oct. 12. Kickoff is scheduled for 4:25pm EDT in Tampa, FL.

The Buccaneers are betting favorites in this matchup, with the spread sitting at -3 (-110).

The 49ers vs. Buccaneers Over/Under is 47.5 total points for the game.

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49ers vs. Buccaneers Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
49ers	+49 -110	47.5 -110	140
Buccaneers	-3 -110	47.5 -110	-165

49ers vs. Buccaneers Prediction

The winning team model predicts the will win this game with confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Buccaneers Spread Prediction

Based on recent against-the-spread trends, the model predicts the will cover the spread with confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

Demarcus Robinson has hit the Receptions Under in 11 of his last 14 games (+7.30 Units / 38% ROI)
Christian McCaffrey has hit the Rushing Yards Under in 8 of his last 9 games (+6.85 Units / 67% ROI)
Brian Robinson has hit the Receptions Under in 11 of his last 15 games (+6.80 Units / 35% ROI)
Christian McCaffrey has hit the Longest Rush Under in his last 5 games (+5.00 Units / 84% ROI)
Christian McCaffrey has hit the Receiving Yards Over in 7 of his last 9 games (+4.60 Units / 44% ROI)

And here are some top NFL player prop bets for Buccaneers players for this matchup, looking at profitable historical betting trends:

Best Buccaneers Player Prop Best Bets Today

Baker Mayfield has hit the TD Passes Over in 14 of his last 18 games (+9.70 Units / 40% ROI)
Bucky Irving has hit the Receptions Over in 12 of his last 17 games (+6.83 Units / 33% ROI)
Bucky Irving has hit the Rushing Yards Over in 11 of his last 17 games (+3.90 Units / 19% ROI)
Rachaad White has hit the Receiving Yards Over in 6 of his last 8 games at home (+3.75 Units / 41% ROI)
Cade Otton has hit the Receptions Under in 9 of his last 15 games (+3.05 Units / 17% ROI)

Receiving Props: Total Receiving Yards for Buccaneers vs 49ers

Player Name	Over	Under
Chris Godwin (TB)	51.5 -118	51.5 -110
Cade Otton (TB)	26.5 -120	26.5 -110
Emeka Egbuka (TB)	69.5 -115	69.5 -115

49ers Best Bets:

The San Francisco 49ers have covered the 1Q Spread in 16 of their last 20 games (+11.95 Units / 52% ROI)
The San Francisco 49ers have hit the 1Q Moneyline in 12 of their last 19 games (+9.85 Units / 41% ROI)
The San Francisco 49ers have hit the 2H Game Total Over in 12 of their last 16 games (+7.51 Units / 43% ROI)
The San Francisco 49ers have hit the 4Q Game Total Over in 12 of their last 17 games (+7.20 Units / 37% ROI)
The San Francisco 49ers have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)

Buccaneers Best Bets:

The Tampa Bay Buccaneers have hit the 3Q Moneyline in 12 of their last 18 games (+10.15 Units / 40% ROI)
The Tampa Bay Buccaneers have covered the 3Q Spread in 13 of their last 18 games (+7.45 Units / 35% ROI)
The Tampa Bay Buccaneers have hit the 1H Game Total Over in 14 of their last 21 games (+7.05 Units / 29% ROI)
The Tampa Bay Buccaneers have hit the 2H Moneyline in 11 of their last 17 games (+6.62 Units / 25% ROI)
The Tampa Bay Buccaneers have hit the Game Total Over in 14 of their last 21 games (+6.30 Units / 27% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 3-2 (+0.8 Units / 14.55% ROI).

49ers are 4-1 when betting on the Moneyline for +4.95 Units / 72.79% ROI
49ers are 3-2 when betting the Over for +0.8 Units / 14.55% ROI
49ers are 2-3 when betting the Under for -1.3 Units / ROI

Buccaneers Against the Spread (ATS) Record

Against the spread this NFL season, the Buccaneers are 3-2 (+0.8 Units / 14.81% ROI).

Buccaneers are 4-1 when betting on the Moneyline for +3.9 Units / 54.17% ROI
Buccaneers are 3-2 when betting the Over for +0.8 Units / 14.55% ROI
Buccaneers are 2-3 when betting the Under for -1.3 Units / -23.64% ROI

San Francisco 49ers: Keys to the Game vs. the Tampa Bay Buccaneers

The Buccaneers have run successful plays on 45% of pass attempts on passes when their QB has been pressured since the 2024 season — best in NFL; League Avg: 31%.

The Buccaneers have a third down conversion rate of 30% on third and 10+ yards to go since the 2024 season — best in NFL; League Avg: 18%.

The Buccaneers have gone three and out 7 times in the 2nd quarter this season — T-most in NFL.

The Buccaneers have targeted TEs 10% of the time (17 Pass Attempts/172 plays) this season — lowest in NFL; League Avg: 21%.

Tampa Bay Buccaneers: Keys to the Game vs. the San Francisco 49ers

The Buccaneers defense has allowed successful plays on 70% of pass attempts with a light front this season — worst in NFL; League Avg: 41%.

The Buccaneers defense has allowed successful plays on 61% of plays with a heavy rush since the 2024 season — worst in NFL; League Avg: 44%.

The Buccaneers defense has blitzed on 43% of plays on 3rd and short this season — highest in NFL; League Avg: 12%.

The Buccaneers defense have allowed 9.2 yards per play on first drive of the game this season — worst in NFL; League Avg: 5.8.

Additional Matchup Notes for San Francisco 49ers vs. Tampa Bay Buccaneers