49ers vs Cardinals Player Prop Bets Tonight – Monday Night Football

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San Francisco 49ers middle linebacker Fred Warner (54) against the Dallas Cowboys during the first half of an NFL wild-card playoff football game in Arlington, Texas, Sunday, Jan. 16, 2022. (AP Photo/Roger Steinman)
(AP Photo/Roger Steinman)
BetMGM Betting @BETMGM Nov 21, 2022, 2:16 PM
  • Highlighting the most popular 49ers vs Cardinals NFL player prop bets for today’s game
  • Plus profitable player prop betting trends for key players

The San Francisco 49ers (5-4) visit Estadio Azteca to take on the Arizona Cardinals (4-6) on Nov. 21. Kickoff is scheduled for 8:15pm EST in Mexico City for Monday Night Football.

Below you can find profitable historical betting trends for various 49ers and Cardinals player prop bets today, ranked by units won and ROI.

All NBA player prop betting odds are provided by the BetMGM Sportsbook.

Best 49ers Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 11, looking at profitable historical betting trends:

  • Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+7.40 Units / 27% ROI)
  • Jimmy Garoppolo has hit the Completions Under in 12 of his last 17 games (+5.80 Units / 26% ROI)
  • George Kittle has hit the Receptions Under in 13 of his last 19 games (+5.45 Units / 20% ROI)
  • Brandon Aiyuk has hit the Receiving Yards Over in 13 of his last 21 games (+4.10 Units / 18% ROI)
  • Tajae Sharpe has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 80% ROI)

Best 49ers Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 11, looking at profitable historical betting trends:

  • Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+7.40 Units / 27% ROI)
  • Jimmy Garoppolo has hit the Completions Under in 12 of his last 17 games (+5.80 Units / 26% ROI)
  • George Kittle has hit the Receptions Under in 13 of his last 19 games (+5.45 Units / 20% ROI)
  • Brandon Aiyuk has hit the Receiving Yards Over in 13 of his last 21 games (+4.10 Units / 18% ROI)
  • Tajae Sharpe has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 80% ROI)

49ers vs. Cardinals Odds, Spread, Over/Under Week 11

SpreadTotal (O/U)Moneyline
49ers-10 -11043 -110-400
Cardinals +10 -11043 -110+310

The 49ers are betting favorites in Week 11, with the spread sitting at -7.5 (-115).

The 49ers vs. Cardinals Over/Under is 43.5 total points for the game.


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.