- The 49ers (5-4) are -7.5 point favorites vs the Cardinals (4-6)
- Total (Over/Under): 43.5 points
- Watch the game on ESPN
The San Francisco 49ers (5-4) visit Estadio Azteca to take on the Arizona Cardinals (4-6) on Nov. 21. Kickoff is scheduled for 8:15pm EST in Mexico City for Monday Night Football.
The 49ers are betting favorites in Week 11, with the spread sitting at -10 (-110).
The 49ers vs. Cardinals Over/Under is 43 total points for the game.
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49ers vs. Cardinals Odds, Spread, Over/Under Week 11
| Spread | Total (O/U) | Moneyline | |
| 49ers | -10 -110 | 43 -110 | -400 |
| Cardinals | +10 -110 | 43 -110 | +310 |
49ers vs. Cardinals Prediction for Week 11
Based on recent trends, the winning team model predicts the 49ers will win this Week 11 game with 72.8% confidence.
49ers vs Cardinals Spread Prediction for Week 11
Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread this Week 11 with 54.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Cardinals, plus offensive & defensive matchups, recent games and key player performances this season.
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Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 11, looking at profitable historical betting trends:
- Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+7.40 Units / 27% ROI)
- Jimmy Garoppolo has hit the Completions Under in 12 of his last 17 games (+5.80 Units / 26% ROI)
- George Kittle has hit the Receptions Under in 13 of his last 19 games (+5.45 Units / 20% ROI)
- Brandon Aiyuk has hit the Receiving Yards Over in 13 of his last 21 games (+4.10 Units / 18% ROI)
- Tajae Sharpe has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 80% ROI)
Best Cardinals Player Prop Best Bets Today
And here are some top NFL player prop bets for Cardinals players for Week 11, looking at profitable historical betting trends:
- Marquise Brown has hit the Receptions Over in 9 of his last 13 games (+5.40 Units / 38% ROI)
- A.J. Green has hit the Receptions Under in 8 of his last 10 games (+5.25 Units / 37% ROI)
- Kyler Murray has hit the Passing Yards Under in 11 of his last 16 games (+4.85 Units / 24% ROI)
- Robby Anderson has hit the Receiving Yards Under in 8 of his last 11 games (+4.25 Units / 31% ROI)
- Zach Ertz has hit the Receptions Over in 11 of his last 17 games (+4.20 Units / 21% ROI)
First Touchdown Scorer Bet for Cardinals vs 49ers
| Player Name | 1st TD Odds |
|---|---|
| Christian McCaffrey | +450 |
| James Conner | +700 |
| Elijah Mitchell | +700 |
| Brandon Aiyuk | +700 |
| Deebo Samuel | +700 |
Anytime Touchdown Scorer Bet for Cardinals vs 49ers
| Player Name | Anytime TD Odds |
|---|---|
| Christian McCaffrey | -140 |
| James Conner | -120 |
| DeAndre Hopkins | +115 |
| Deebo Samuel | +125 |
| Elijah Mitchell | +125 |
Receiving Props: Total Receiving Yards for Cardinals vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Deebo Samuel | 53.5 -115 | 53.5 -115 |
| James Conner | 20.5 -110 | 20.5 -120 |
| Brandon Aiyuk | 54.5 -120 | 54.5 -110 |
| Jauan Jennings | 14.5 -110 | 14.5 -120 |
| Kyle Juszczyk | 7.5 -110 | 7.5 -120 |
Rushing Props: Total Rushing Yards for Cardinals vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Jimmy Garoppolo | 1.5 -115 | 1.5 -115 |
| James Conner | 50.5 -120 | 50.5 -110 |
| Christian Mccaffrey | 62.5 -115 | 62.5 -115 |
49ers Best Bets for Week 11:
- The San Francisco 49ers have hit the Game Total Under in 13 of their last 17 games (+8.60 Units / 46% ROI)
- The San Francisco 49ers have covered the Spread in 14 of their last 21 games (+6.45 Units / 28% ROI)
- The San Francisco 49ers have hit the 3Q Game Total Under in 9 of their last 12 games (+5.50 Units / 40% ROI)
- The San Francisco 49ers have covered the 2Q Spread in 6 of their last 7 away games (+5.05 Units / 65% ROI)
- The San Francisco 49ers have hit the 1H Game Total Over in their last 5 games (+5.00 Units / 90% ROI)
Cardinals Best Bets for Week 11:
- The Arizona Cardinals have hit the 2H Game Total Over in 13 of their last 17 games (+8.35 Units / 44% ROI)
- The Arizona Cardinals have hit the 3Q Moneyline in 8 of their last 14 games (+3.70 Units / 24% ROI)
- The Arizona Cardinals have hit the Team Total Under in 6 of their last 8 games at home (+3.65 Units / 41% ROI)
- The Arizona Cardinals have covered the 2Q Spread in 4 of their last 5 games at home (+3.20 Units / 59% ROI)
- The Arizona Cardinals have hit the 3Q Game Total Over in 4 of their last 8 games at home (+3.00 Units / 34% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 4-5 (-1.5 Units / -15.23% ROI).
- 49ers are 5-4 when betting on the Moneyline for -1.75 Units / -9.16% ROI
- 49ers are 3-6 when betting the Over for -3.6 Units / -36.36% ROI
- 49ers are 6-3 when betting the Under for +2.7 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals have gone 5-5 (-0.55 Units / -4.98% ROI).
- Cardinals are 4-6 when betting on the Moneyline for -1.15 Units / -10.22% ROI
- Cardinals are 6-4 when betting the Over for +1.6 Units / 14.55% ROI
- Cardinals are 4-6 when betting the Under for -2.6 Units / -23.64% ROI
San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals
The 49ers are undefeated (10-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .539.
The 49ers are 2-1 (.667) when getting more than 3 points since the 2021 season — tied for best in NFL; League Avg: .314.
The 49ers are 12-1 (.923) when allowing less than 100 rushing yards since the 2021 season — best in NFL; League Avg: .661.
The 49ers are undefeated (8-0) when not committing any turnovers since the 2021 season — tied for best in NFL; League Avg: .734.
Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers
The Cardinals are 1-4 (.200) at home this season — 2nd-worst in NFL; League Avg: .559.
The Cardinals are winless (0-4) when allowing 3 or more sacks this season — tied for worst in NFL; League Avg: .378.
The Cardinals are winless (0-6) when allowing 100 or more rushing yards this season — tied for worst in NFL; League Avg: .402.
The Cardinals are undefeated (4-0) when allowing less than 3 explosive runs this season — tied for best in NFL; League Avg: .567.
Additional Matchup Notes for San Francisco 49ers vs. Arizona Cardinals
Cardinals RBs have rushed for 10 or more yards on just 7.0% of 187 carries this season — second-worst in NFL. The 49ers have allowed 10+ yards on just 4.6% of carries to RBs this season — best in NFL.
Cardinals RBs have averaged just 74.3 rushing yards per game this season — fifth-worst in NFL. The 49ers have allowed an average of just 83.8 rushing yards per game this season — best in NFL.
Cardinals RBs have averaged just 67.2 rushing yards per game since Week 7 — fifth-worst in NFL. The 49ers have allowed an average of just 74.7 rushing yards per game since Week 7 — third-best in NFL.
The 49ers have a third down conversion rate of 45.5% on 3rd and 10+ YTG this season — best in NFL. The Cardinals defense has allowed a third down conversion rate of 30.3% on 3rd and 10+ YTG this season — third-worst in NFL.
49ers RBs have rushed for 10 or more yards on 13.3% of 188 carries this season — fourth-best in NFL. The Cardinals have allowed 10+ yards on 15.8% of carries to RBs this season — second-worst in NFL.
The 49ers have run successful plays on 52.3% of pass attempts this season — fifth-best in NFL. Cardinals have allowed successful plays on 51.7% of pass attempts this season — third-worst in NFL.
San Francisco 49ers Offense: Important Stats for Week 11
The 49ers have a third down conversion rate of 46% on third and 10+ yards to go this season — best in NFL; League Avg: 20%.
The 49ers have an average drive start position from the 16.4 yard line in close and late situations since the 2021 season — worst in NFL; League Avg: 22.5.
The 49ers have an average drive start position from the 24.0 yard line since the 2021 season — worst in NFL; League Avg: 26.4.
The 49ers have gone three and out on 14% of their drives since the 2021 season — 2nd-best in NFL; League Avg: 20%.
Arizona Cardinals Offense: Important Stats for Week 11
The Cardinals have run successful plays on 64% of rush attempts in close and late situations this season — best in NFL; League Avg: 43%.
The Cardinals have completed passes for 20+ yards on just 26 of their 401 total passing attempts (7%) this season — 3rd-worst in NFL; League Avg: 9%.
The Cardinals converted first downs on 36 of 102 plays (35%) on 3rd and long last season — best in NFL; League Avg: 25%.
The Cardinals have gone three and out 6 times in the 3rd quarter since Week 7 — tied for most in NFL.
San Francisco 49ers Defense: Important Stats for Week 11
The 49ers defense did not allow a successful play on any play in the 4th quarter in Week 10 — best in NFL; League Avg: 41%.
The 49ers defense has allowed a third down conversion rate of 79% on 3rd and short this season — worst in NFL; League Avg: 59%.
The 49ers defense has allowed successful plays on 36% of rush attempts this season — 2nd-best in NFL; League Avg: 44%.
The 49ers defense has allowed a third down conversion rate of 12% on 3rd and long this season — best in NFL; League Avg: 25%.
Arizona Cardinals Defense: Important Stats for Week 11
The Cardinals defense has allowed scores on 48% of opponent drives in the 1st quarter this season — tied for worst in NFL; League Avg: 28%.
The Cardinals defense has allowed 16 TD passes in the red zone this season — tied for most in NFL.
The Cardinals defense has allowed 33.5 Points per Game (134/4) since Week 7 — worst in NFL; League Avg: 22.3.
The Cardinals defense has allowed a passer rating of 89.3 when they have pressured the QB (160 Pass Attempts) since the 2021 season — 2nd-worst in NFL; League Avg: 56.4.
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