49ers vs Cardinals Prediction, Odds & Best Prop Bets – NFL, Week 11, MNF

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Kyler Murray Arizona Cardinals
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BetMGM Betting @BETMGM Nov 21, 2022, 12:45 PM
  • The 49ers (5-4) are -7.5 point favorites vs the Cardinals (4-6)
  • Total (Over/Under): 43.5 points
  • Watch the game on ESPN

The San Francisco 49ers (5-4) visit Estadio Azteca to take on the Arizona Cardinals (4-6) on Nov. 21. Kickoff is scheduled for 8:15pm EST in Mexico City for Monday Night Football.

The 49ers are betting favorites in Week 11, with the spread sitting at -10 (-110).

The 49ers vs. Cardinals Over/Under is 43 total points for the game.

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49ers vs. Cardinals Odds, Spread, Over/Under Week 11

SpreadTotal (O/U)Moneyline
49ers-10 -11043 -110-400
Cardinals +10 -11043 -110+310

49ers vs. Cardinals Prediction for Week 11

Based on recent trends, the winning team model predicts the 49ers will win this Week 11 game with 72.8% confidence.

49ers vs Cardinals Spread Prediction for Week 11

Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread this Week 11 with 54.0% confidence.

Both predictions factor in up-to-date player injuries for both the 49ers and Cardinals, plus offensive & defensive matchups, recent games and key player performances this season.


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Best 49ers Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 11, looking at profitable historical betting trends:

  • Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+7.40 Units / 27% ROI)
  • Jimmy Garoppolo has hit the Completions Under in 12 of his last 17 games (+5.80 Units / 26% ROI)
  • George Kittle has hit the Receptions Under in 13 of his last 19 games (+5.45 Units / 20% ROI)
  • Brandon Aiyuk has hit the Receiving Yards Over in 13 of his last 21 games (+4.10 Units / 18% ROI)
  • Tajae Sharpe has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 80% ROI)

Best Cardinals Player Prop Best Bets Today

And here are some top NFL player prop bets for Cardinals players for Week 11, looking at profitable historical betting trends:

  • Marquise Brown has hit the Receptions Over in 9 of his last 13 games (+5.40 Units / 38% ROI)
  • A.J. Green has hit the Receptions Under in 8 of his last 10 games (+5.25 Units / 37% ROI)
  • Kyler Murray has hit the Passing Yards Under in 11 of his last 16 games (+4.85 Units / 24% ROI)
  • Robby Anderson has hit the Receiving Yards Under in 8 of his last 11 games (+4.25 Units / 31% ROI)
  • Zach Ertz has hit the Receptions Over in 11 of his last 17 games (+4.20 Units / 21% ROI)

First Touchdown Scorer Bet for Cardinals vs 49ers

Player Name 1st TD Odds
Christian McCaffrey +450
James Conner +700
Elijah Mitchell +700
Brandon Aiyuk +700
Deebo Samuel +700

Anytime Touchdown Scorer Bet for Cardinals vs 49ers

Player Name Anytime TD Odds
Christian McCaffrey -140
James Conner -120
DeAndre Hopkins +115
Deebo Samuel +125
Elijah Mitchell +125

Receiving Props: Total Receiving Yards for Cardinals vs 49ers

Player Name Over Under
Deebo Samuel 53.5 -115 53.5 -115
James Conner 20.5 -110 20.5 -120
Brandon Aiyuk 54.5 -120 54.5 -110
Jauan Jennings 14.5 -110 14.5 -120
Kyle Juszczyk 7.5 -110 7.5 -120

Rushing Props: Total Rushing Yards for Cardinals vs 49ers

Player Name Over Under
Jimmy Garoppolo 1.5 -115 1.5 -115
James Conner 50.5 -120 50.5 -110
Christian Mccaffrey 62.5 -115 62.5 -115
  • The San Francisco 49ers have hit the Game Total Under in 13 of their last 17 games (+8.60 Units / 46% ROI)
  • The San Francisco 49ers have covered the Spread in 14 of their last 21 games (+6.45 Units / 28% ROI)
  • The San Francisco 49ers have hit the 3Q Game Total Under in 9 of their last 12 games (+5.50 Units / 40% ROI)
  • The San Francisco 49ers have covered the 2Q Spread in 6 of their last 7 away games (+5.05 Units / 65% ROI)
  • The San Francisco 49ers have hit the 1H Game Total Over in their last 5 games (+5.00 Units / 90% ROI)
  • The Arizona Cardinals have hit the 2H Game Total Over in 13 of their last 17 games (+8.35 Units / 44% ROI)
  • The Arizona Cardinals have hit the 3Q Moneyline in 8 of their last 14 games (+3.70 Units / 24% ROI)
  • The Arizona Cardinals have hit the Team Total Under in 6 of their last 8 games at home (+3.65 Units / 41% ROI)
  • The Arizona Cardinals have covered the 2Q Spread in 4 of their last 5 games at home (+3.20 Units / 59% ROI)
  • The Arizona Cardinals have hit the 3Q Game Total Over in 4 of their last 8 games at home (+3.00 Units / 34% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers have gone 4-5 (-1.5 Units / -15.23% ROI).

  • 49ers are 5-4 when betting on the Moneyline for -1.75 Units / -9.16% ROI
  • 49ers are 3-6 when betting the Over for -3.6 Units / -36.36% ROI
  • 49ers are 6-3 when betting the Under for +2.7 Units / ROI

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals have gone 5-5 (-0.55 Units / -4.98% ROI).

  • Cardinals are 4-6 when betting on the Moneyline for -1.15 Units / -10.22% ROI
  • Cardinals are 6-4 when betting the Over for +1.6 Units / 14.55% ROI
  • Cardinals are 4-6 when betting the Under for -2.6 Units / -23.64% ROI

San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals

The 49ers are undefeated (10-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .539.

The 49ers are 2-1 (.667) when getting more than 3 points since the 2021 season — tied for best in NFL; League Avg: .314.

The 49ers are 12-1 (.923) when allowing less than 100 rushing yards since the 2021 season — best in NFL; League Avg: .661.

The 49ers are undefeated (8-0) when not committing any turnovers since the 2021 season — tied for best in NFL; League Avg: .734.

Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers

The Cardinals are 1-4 (.200) at home this season — 2nd-worst in NFL; League Avg: .559.

The Cardinals are winless (0-4) when allowing 3 or more sacks this season — tied for worst in NFL; League Avg: .378.

The Cardinals are winless (0-6) when allowing 100 or more rushing yards this season — tied for worst in NFL; League Avg: .402.

The Cardinals are undefeated (4-0) when allowing less than 3 explosive runs this season — tied for best in NFL; League Avg: .567.

Additional Matchup Notes for San Francisco 49ers vs. Arizona Cardinals

Cardinals RBs have rushed for 10 or more yards on just 7.0% of 187 carries this season — second-worst in NFL. The 49ers have allowed 10+ yards on just 4.6% of carries to RBs this season — best in NFL.

Cardinals RBs have averaged just 74.3 rushing yards per game this season — fifth-worst in NFL. The 49ers have allowed an average of just 83.8 rushing yards per game this season — best in NFL.

Cardinals RBs have averaged just 67.2 rushing yards per game since Week 7 — fifth-worst in NFL. The 49ers have allowed an average of just 74.7 rushing yards per game since Week 7 — third-best in NFL.

The 49ers have a third down conversion rate of 45.5% on 3rd and 10+ YTG this season — best in NFL. The Cardinals defense has allowed a third down conversion rate of 30.3% on 3rd and 10+ YTG this season — third-worst in NFL.

49ers RBs have rushed for 10 or more yards on 13.3% of 188 carries this season — fourth-best in NFL. The Cardinals have allowed 10+ yards on 15.8% of carries to RBs this season — second-worst in NFL.

The 49ers have run successful plays on 52.3% of pass attempts this season — fifth-best in NFL. Cardinals have allowed successful plays on 51.7% of pass attempts this season — third-worst in NFL.

San Francisco 49ers Offense: Important Stats for Week 11

The 49ers have a third down conversion rate of 46% on third and 10+ yards to go this season — best in NFL; League Avg: 20%.

The 49ers have an average drive start position from the 16.4 yard line in close and late situations since the 2021 season — worst in NFL; League Avg: 22.5.

The 49ers have an average drive start position from the 24.0 yard line since the 2021 season — worst in NFL; League Avg: 26.4.

The 49ers have gone three and out on 14% of their drives since the 2021 season — 2nd-best in NFL; League Avg: 20%.

Arizona Cardinals Offense: Important Stats for Week 11

The Cardinals have run successful plays on 64% of rush attempts in close and late situations this season — best in NFL; League Avg: 43%.

The Cardinals have completed passes for 20+ yards on just 26 of their 401 total passing attempts (7%) this season — 3rd-worst in NFL; League Avg: 9%.

The Cardinals converted first downs on 36 of 102 plays (35%) on 3rd and long last season — best in NFL; League Avg: 25%.

The Cardinals have gone three and out 6 times in the 3rd quarter since Week 7 — tied for most in NFL.

San Francisco 49ers Defense: Important Stats for Week 11

The 49ers defense did not allow a successful play on any play in the 4th quarter in Week 10 — best in NFL; League Avg: 41%.

The 49ers defense has allowed a third down conversion rate of 79% on 3rd and short this season — worst in NFL; League Avg: 59%.

The 49ers defense has allowed successful plays on 36% of rush attempts this season — 2nd-best in NFL; League Avg: 44%.

The 49ers defense has allowed a third down conversion rate of 12% on 3rd and long this season — best in NFL; League Avg: 25%.

Arizona Cardinals Defense: Important Stats for Week 11

The Cardinals defense has allowed scores on 48% of opponent drives in the 1st quarter this season — tied for worst in NFL; League Avg: 28%.

The Cardinals defense has allowed 16 TD passes in the red zone this season — tied for most in NFL.

The Cardinals defense has allowed 33.5 Points per Game (134/4) since Week 7 — worst in NFL; League Avg: 22.3.

The Cardinals defense has allowed a passer rating of 89.3 when they have pressured the QB (160 Pass Attempts) since the 2021 season — 2nd-worst in NFL; League Avg: 56.4.

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.