49ers vs Eagles Prediction, Odds & Best Prop Bets โ€“ NFC Wild Card Playoffs

General view of Lincoln Financial Field during an NFL football game between the San Francisco 49ers and Philadelphia Eagles, Sunday, Sept. 19, 2021, in Philadelphia.
(AP Photo/Rich Schultz)
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  • The Eagles are -4.5 point favorites vs the 49ers
  • Total (Over/Under): 45 points
  • Watch this game on FOX | FOXD

The San Francisco 49ers visit Lincoln Financial Field to take on the Philadelphia Eagles on Jan. 11. Kickoff is scheduled for 4:30pm EST in Philadelphia, PA.

The Eagles are betting favorites in this playoff matchup, with the spread sitting at -4.5 (-110).

The 49ers vs. Eagles Over/Under is 45 total points for the game.

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49ers vs. Eagles Odds, Spread, Over/Under

49ers vs. Eagles Prediction

The winning team model predicts the Eagles will win this playoff game with 64.5% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Eagles Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 55.2% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

  • Christian McCaffrey has hit the Longest Rush Under in 12 of his last 17 games (+6.45 Units / 33% ROI)
  • Christian McCaffrey has hit the Receiving Yards Under in his last 5 games (+5.00 Units / 88% ROI)
  • Jauan Jennings has hit the Receptions Over in 8 of his last 11 games (+5.00 Units / 35% ROI)
  • George Kittle has hit the Longest Reception Over in 6 of his last 7 games (+4.90 Units / 62% ROI)
  • George Kittle has hit the Receiving Yards Over in 6 of his last 7 games (+4.85 Units / 60% ROI)

And here are some top NFL player prop bets for Eagles players for this matchup, looking at profitable historical betting trends:

Best Eagles Player Prop Best Bets Today

  • Jalen Hurts has hit the Carries Under in 16 of his last 20 games (+11.65 Units / 48% ROI)
  • Saquon Barkley has hit the Longest Rush Under in 13 of his last 16 games (+9.60 Units / 53% ROI)
  • Jalen Hurts has hit the Interceptions Under in 16 of his last 20 games (+8.85 Units / 25% ROI)
  • Jahan Dotson has hit the Longest Reception Over in his last 6 games at home (+6.00 Units / 87% ROI)
  • Jahan Dotson has hit the Receiving Yards Over in 7 of his last 8 games at home (+5.89 Units / 65% ROI)

First Touchdown Scorer Bet for Eagles vs 49ers

Player Name 1st TD Odds
Brock Purdy (SF) +3000
Christian McCaffrey (SF) +500
Brian Robinson Jr. (SF) +4000
Isaac Guerendo (SF) +12500
Jordan James (SF) +12500

Receiving Props: Total Receiving Yards for Eagles vs 49ers

Player Name Over Under
Dallas Goedert (PHI) 37.5 -118 37.5 -110
DeVonta Smith (PHI) 53.5 -115 53.5 -115
Kyle Juszczyk (SF) 4.5 -120 4.5 -110
Jahan Dotson (PHI) 6.5 -110 6.5 -118
Jauan Jennings (SF) 41.5 -115 41.5 -115

Rushing Props: Total Rushing Yards for Eagles vs 49ers

Player Name Over Under
Jalen Hurts (PHI) 28.5 -118 28.5 -110
Brock Purdy (SF) 18.5 -115 18.5 -115
Brian Robinson Jr. (SF) 14.5 -115 14.5 -115
Saquon Barkley (PHI) 83.5 -115 83.5 -115
Christian McCaffrey (SF) 61.5 -118 61.5 -110
  • The San Francisco 49ers have hit the Moneyline in 14 of their last 19 games (+12.05 Units / 34% ROI)
  • The San Francisco 49ers have hit the 3Q Game Total Over in 12 of their last 14 games (+9.40 Units / 53% ROI)
  • The San Francisco 49ers have hit the 1H Game Total Over in their last 8 away games (+8.00 Units / 89% ROI)
  • The San Francisco 49ers have hit the 1H Moneyline in 11 of their last 16 games (+6.65 Units / 24% ROI)
  • The San Francisco 49ers have hit the Game Total Over in 13 of their last 20 games (+6.40 Units / 29% ROI)
  • The Philadelphia Eagles have hit the 3Q Game Total Under in 15 of their last 21 games (+8.25 Units / 34% ROI)
  • The Philadelphia Eagles have hit the 1Q Moneyline in 12 of their last 22 games (+4.70 Units / 13% ROI)
  • The Philadelphia Eagles have covered the 1Q Spread in 13 of their last 22 games (+4.60 Units / 18% ROI)
  • The Philadelphia Eagles have hit the 1Q Game Total Over in 13 of their last 22 games (+3.20 Units / 13% ROI)
  • The Philadelphia Eagles have covered the 3Q Spread in 12 of their last 21 games (+2.90 Units / 12% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 10-6 (+3.5 Units / 18.82% ROI).

  • 49ers are 12-5 when betting on the Moneyline for +8.95 Units / 27% ROI
  • 49ers are 10-6 when betting the Over for +3.4 Units / 18.18% ROI
  • 49ers are 6-10 when betting the Under for -5 Units / ROI

Eagles Against the Spread (ATS) Record

Against the spread this NFL season, the Eagles are 10-7 (+2.3 Units / 12.33% ROI).

  • Eagles are 11-6 when betting on the Moneyline for -2.45 Units / -5.65% ROI
  • Eagles are 7-10 when betting the Over for -4 Units / -21.39% ROI
  • Eagles are 10-7 when betting the Under for +2.3 Units / 12.3% ROI

San Francisco 49ers: Keys to the Game vs. the Philadelphia Eagles

The 49ers are undefeated (5-0) when within 7 points at the two minute warning this season — best in NFL; League Avg: .496.

The 49ers are undefeated (10-0) when leading at the end of the third quarter this season — T-best in NFL; League Avg: .836.

The 49ers are 7-3 (.700) when making 5 or more explosive passes in a game this season — T-8th-best in NFL; League Avg: .566.

The 49ers are 9-1 (.900) when possessing the ball longer than their opponent this season — 5th-best in NFL; League Avg: .650.

Philadelphia Eagles: Keys to the Game vs. the San Francisco 49ers

The Eagles are 8-3 (.727) when allowing less than 3 sacks this season — 9th-best in NFL. The 49ers have averaged just 1.2 sacks per game over that time span — worst in NFL.

The Eagles are 11-2 (.846) when not throwing an interception this season — 9th-best in NFL. The 49ers have intercepted 6 passes this season — T-2nd-fewest in NFL.

The Eagles are winless (0-4) when throwing at least 1 interception this season — T-worst in NFL; League Avg: .337.

The Eagles are winless (0-4) when committing 2 or more turnovers this season — T-worst in NFL; League Avg: .229.

Additional Matchup Notes for San Francisco 49ers vs. Philadelphia Eagles

The Eagles are 8-3 (.727) when allowing less than 3 sacks this season — 9th-best in NFL. The 49ers have averaged just 1.2 sacks per game over that time span — worst in NFL.

The Eagles are 11-2 (.846) when not throwing an interception this season — 9th-best in NFL. The 49ers have intercepted 6 passes this season — T-2nd-fewest in NFL.

The Eagles are winless (0-4) when throwing at least 1 interception this season — T-worst in NFL; League Avg: .337.

The Eagles are winless (0-4) when committing 2 or more turnovers this season — T-worst in NFL; League Avg: .229.

The 49ers are undefeated (5-0) when within 7 points at the two minute warning this season — best in NFL; League Avg: .496.

The 49ers are undefeated (10-0) when leading at the end of the third quarter this season — T-best in NFL; League Avg: .836.

The 49ers are 7-3 (.700) when making 5 or more explosive passes in a game this season — T-8th-best in NFL; League Avg: .566.

The 49ers are 9-1 (.900) when possessing the ball longer than their opponent this season — 5th-best in NFL; League Avg: .650.

San Francisco 49ers Offense: Important Stats

The 49ers are undefeated (5-0) when within 7 points at the two minute warning this season — best in NFL; League Avg: .496.

The 49ers are undefeated (10-0) when leading at the end of the third quarter this season — T-best in NFL; League Avg: .836.

The 49ers are 7-3 (.700) when making 5 or more explosive passes in a game this season — T-8th-best in NFL; League Avg: .566.

The 49ers are 9-1 (.900) when possessing the ball longer than their opponent this season — 5th-best in NFL; League Avg: .650.

Philadelphia Eagles Offense: Important Stats

The Eagles are 8-3 (.727) when allowing less than 3 sacks this season — 9th-best in NFL. The 49ers have averaged just 1.2 sacks per game over that time span — worst in NFL.

The Eagles are 11-2 (.846) when not throwing an interception this season — 9th-best in NFL. The 49ers have intercepted 6 passes this season — T-2nd-fewest in NFL.

The Eagles are winless (0-4) when throwing at least 1 interception this season — T-worst in NFL; League Avg: .337.

The Eagles are winless (0-4) when committing 2 or more turnovers this season — T-worst in NFL; League Avg: .229.

San Francisco 49ers Defense: Important Stats

The 49ers are undefeated (5-0) when within 7 points at the two minute warning this season — best in NFL; League Avg: .496.

The 49ers are undefeated (10-0) when leading at the end of the third quarter this season — T-best in NFL; League Avg: .836.

The 49ers are 7-3 (.700) when making 5 or more explosive passes in a game this season — T-8th-best in NFL; League Avg: .566.

The 49ers are 9-1 (.900) when possessing the ball longer than their opponent this season — 5th-best in NFL; League Avg: .650.

Philadelphia Eagles Defense: Important Stats

The Eagles are 8-3 (.727) when allowing less than 3 sacks this season — 9th-best in NFL. The 49ers have averaged just 1.2 sacks per game over that time span — worst in NFL.

The Eagles are 11-2 (.846) when not throwing an interception this season — 9th-best in NFL. The 49ers have intercepted 6 passes this season — T-2nd-fewest in NFL.

The Eagles are winless (0-4) when throwing at least 1 interception this season — T-worst in NFL; League Avg: .337.

The Eagles are winless (0-4) when committing 2 or more turnovers this season — T-worst in NFL; League Avg: .229.

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.