49ers vs Giants Prediction, Odds & Best Prop Bets – NFL, Week 9

BetMGM Betting Oct 28, 2025, 9:21 PM

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A general overall interior view of MetLife Stadium as the New York Giants take on the Carolina Panthers during the first half an NFL football game, Sunday, Sept. 18, 2022, in East Rutherford, N.J. (AP Photo/Seth Wenig)

(AP Photo/Seth Wenig)

The Favorite Team are Favorite Spread point favorites vs the Underdog Team
Total (Over/Under): 48.5 points
Watch this game on CBS

The San Francisco 49ers (5-3-0) visit MetLife Stadium to take on the New York Giants (2-6-0) on Nov. 2. Kickoff is scheduled for 1:00pm EDT in East Rutherford, NJ.

The are betting favorites in this matchup, with the spread sitting at ().

The 49ers vs. Giants Over/Under is 48.5 total points for the game.

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49ers vs. Giants Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
49ers	+49 -118	48.5 -110	-155
Giants	+2.5 -102	48.5 -110	130

49ers vs. Giants Prediction

The winning team model predicts the 49ers will win this game with 57.9% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Giants Spread Prediction

Based on recent against-the-spread trends, the model predicts the Giants will cover the spread with 54.4% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

Christian McCaffrey has hit the Rushing Yards Under in 10 of his last 12 games (+7.75 Units / 57% ROI)
Christian McCaffrey has hit the Longest Rush Under in 7 of his last 8 games (+5.85 Units / 63% ROI)
Kendrick Bourne has hit the Receiving Yards Over in 7 of his last 8 away games (+5.80 Units / 62% ROI)
Christian McCaffrey has hit the Receiving Yards Over in 9 of his last 12 games (+5.45 Units / 39% ROI)
Brian Robinson has hit the Receptions Under in 9 of his last 13 games (+4.80 Units / 28% ROI)

And here are some top NFL player prop bets for Giants players for this matchup, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today

Darius Slayton has hit the Receptions Under in 11 of his last 14 games (+7.95 Units / 40% ROI)
Graham Gano has hit the Field Goals Under in his last 5 games at home (+5.00 Units / 56% ROI)
Jaxson Dart has hit the TD Passes Over in his last 5 games (+5.00 Units / 47% ROI)
Russell Wilson has hit the TD Passes Over in 8 of his last 14 games (+4.55 Units / 27% ROI)
Wan’Dale Robinson has hit the Receptions Over in 12 of his last 18 games (+4.50 Units / 19% ROI)

49ers Best Bets:

The San Francisco 49ers have covered the 1Q Spread in 14 of their last 20 games (+6.75 Units / 27% ROI)
The San Francisco 49ers have hit the 3Q Game Total Over in 12 of their last 17 games (+6.20 Units / 30% ROI)
The San Francisco 49ers have hit the 2Q Game Total Over in 8 of their last 10 away games (+5.75 Units / 49% ROI)
The San Francisco 49ers have hit the 1H Game Total Over in 8 of their last 11 away games (+5.75 Units / 46% ROI)
The San Francisco 49ers have hit the 1Q Moneyline in 9 of their last 19 games (+4.85 Units / 21% ROI)

Giants Best Bets:

The New York Giants have hit the 4Q Moneyline in 5 of their last 8 games at home (+6.00 Units / 75% ROI)
The New York Giants have covered the 4Q Spread in 7 of their last 8 games at home (+5.75 Units / 60% ROI)
The New York Giants have hit the Moneyline in 5 of their last 10 games at home (+5.55 Units / 47% ROI)
The New York Giants have hit the 2H Moneyline in 4 of their last 8 games at home (+4.89 Units / 61% ROI)
The New York Giants have hit the 3Q Game Total Under in 12 of their last 18 games (+4.50 Units / 20% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 4-4 (-0.4 Units / -4.55% ROI).

49ers are 5-3 when betting on the Moneyline for +3.95 Units / 39.9% ROI
49ers are 4-3 when betting the Over for +0.7 Units / 7.95% ROI
49ers are 3-4 when betting the Under for -1.4 Units / ROI

Giants Against the Spread (ATS) Record

Against the spread this NFL season, the Giants are 4-4 (-0.4 Units / -4.55% ROI).

Giants are 2-6 when betting on the Moneyline for -0.55 Units / -6.88% ROI
Giants are 4-4 when betting the Over for -0.4 Units / -4.55% ROI
Giants are 4-4 when betting the Under for -0.4 Units / -4.55% ROI

San Francisco 49ers: Keys to the Game vs. the New York Giants

The Giants defense allowed 7 broken tackles in Week 8 — most in NFL.

The Giants defense have averaged 38.1 defensive penalty yards per game (305/8) this season — 2nd-worst in NFL; League Avg: 22.7.

The Giants defense allowed successful plays on 69% of plays in the 4th quarter in Week 8 — 2nd-worst in NFL; League Avg: 41%.

The Giants defense allowed successful plays on 63% of rush attempts in Week 8 — 2nd-worst in NFL; League Avg: 45%.

New York Giants: Keys to the Game vs. the San Francisco 49ers

The 49ers have targeted RBs 27% of the time (80 Pass Attempts/299 plays) this season — highest in NFL; League Avg: 17%.

The 49ers ran successful plays on 18% of pass attempts in the 1st half in Week 8 — worst in NFL; League Avg: 49%.

The 49ers went three and out on 56% of their drives in Week 8 — worst in NFL; League Avg: 20%.

The 49ers have 45 of 155 (29%) first downs have come on the ground (29%) this season — lowest in NFL; League Avg: 37%.

Additional Matchup Notes for San Francisco 49ers vs. New York Giants