49ers vs Panthers Prediction, Odds & Best Prop Bets – NFL, Week 5

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Baker Mayfield Carolina Panthers
BetMGM Betting @BETMGM Oct 09, 2022, 9:12 AM
  • The 49ers (2-2) are -6.5 point favorites vs the Panthers (1-3)
  • Total (Over/Under): 39.5 points
  • Watch the game on CBS

The San Francisco 49ers (2-2) visit Bank of America Stadium to take on the Carolina Panthers (1-3) on Oct. 9. Kickoff is scheduled for 4:05pm EDT in Charlotte.

The 49ers are betting favorites in Week 5, with the spread sitting at -6.5 (-110).

The 49ers vs. Panthers Over/Under is 39.5 total points for the game.

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49ers vs. Panthers Odds, Spread, Over/Under Week 5

SpreadTotal (O/U)Moneyline
49ers-6.5 -11039.5 -110-275
Panthers +6.5 -11039.5 -110+220

49ers vs. Panthers Prediction for Week 5

Based on recent trends, the winning team model predicts the 49ers will win this Week 5 game with 74.5% confidence.

49ers vs Panthers Spread Prediction for Week 5

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 5 with 60.0% confidence.

Both predictions factor in up-to-date player injuries for both the 49ers and Panthers, plus offensive & defensive matchups, recent games and key player performances this season.


Best 49ers Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 5, looking at profitable historical betting trends:

  • Jimmy Garoppolo has hit the Completions Under in 12 of his last 15 games (+8.50 Units / 43% ROI)
  • Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+8.00 Units / 29% ROI)
  • George Kittle has hit the Receptions Under in 11 of his last 15 games (+6.05 Units / 27% ROI)
  • George Kittle has hit the Receiving Yards Under in 10 of his last 15 games (+3.95 Units / 21% ROI)
  • Ray-Ray McCloud has hit the Receiving Yards Over in 5 of his last 6 games (+3.80 Units / 55% ROI)
  • Best Panthers Player Prop Best Bets Today

    And here are some top NFL player prop bets for Panthers players for Week 5, looking at profitable historical betting trends:

  • D.J. Moore has hit the Receiving Yards Under in 13 of his last 16 games (+9.35 Units / 46% ROI)
  • Robby Anderson has hit the Receiving Yards Under in 12 of his last 16 games (+7.00 Units / 35% ROI)
  • Laviska Shenault Jr. has hit the Receptions Over in his last 6 games at home (+6.50 Units / 92% ROI)
  • Sam Darnold has hit the TD Passes Under in his last 6 games (+6.30 Units / 70% ROI)
  • Sam Darnold has hit the Passing Yards Under in his last 6 games (+6.00 Units / 82% ROI)
  • First Touchdown Scorer Bet for Panthers vs 49ers

    Player Name 1st TD Odds
    Deebo Samuel +500
    Jeff Wilson +600
    Christian McCaffrey +700
    Brandon Aiyuk +900
    George Kittle +900

    Anytime Touchdown Scorer Bet for Panthers vs 49ers

    Player Name Anytime TD Odds
    Christian McCaffrey -115
    Deebo Samuel -115
    Jeff Wilson +100
    Brandon Aiyuk +160
    DJ Moore +170

    Receiving Props: Total Receiving Yards for Panthers vs 49ers

    Player Name Over Under
    DJ Moore 49.5 -115 49.5 -110
    Deebo Samuel 55.5 -115 55.5 -115
    Brandon Aiyuk 45.5 -115 45.5 -115
    Christian McCaffrey 36.5 -110 36.5 -115
    Robby Anderson 35.5 -115 35.5 -110

    Rushing Props: Total Rushing Yards for Panthers vs 49ers

    Player Name Over Under
    Christian McCaffrey 52.5 -115 52.5 -115
    Baker Mayfield 7.5 -120 7.5 -110
    Jeff Wilson Jr. 68.5 -115 68.5 -110
    Deebo Samuel 22.5 -110 22.5 -115
    Jimmy Garoppolo 1.5 -110 1.5 -120
  • The San Francisco 49ers have hit the Game Total Under in 11 of their last 12 games (+9.90 Units / 75% ROI)
  • The San Francisco 49ers have hit the 1H Game Total Under in 9 of their last 10 games (+9.00 Units / 81% ROI)
  • The San Francisco 49ers have covered the Spread in 12 of their last 16 games (+7.75 Units / 44% ROI)
  • The San Francisco 49ers have hit the 1Q Game Total Under in 10 of their last 12 games (+7.70 Units / 56% ROI)
  • The San Francisco 49ers have covered the 1H Spread in 12 of their last 16 games (+7.70 Units / 45% ROI)
  • The Carolina Panthers have hit the 1Q Moneyline in 7 of their last 17 games (+7.25 Units / 38% ROI)
  • The Carolina Panthers have scored first in 9 of their last 13 games (+6.70 Units / 46% ROI)
  • The Carolina Panthers have hit the Team Total Under in 10 of their last 15 games (+5.55 Units / 33% ROI)
  • The Carolina Panthers have hit the 1Q Game Total Under in 10 of their last 15 games (+5.30 Units / 30% ROI)
  • The Carolina Panthers have hit the 2H Game Total Over in their last 5 games (+5.00 Units / 90% ROI)
  • 49ers Against the Spread (ATS) Record

    Against the spread this NFL season, the 49ers have gone 2-2 (-0.2 Units / -4.55% ROI).

    • 49ers are 2-2 when betting on the Moneyline for -1.85 Units / -20.67% ROI
    • 49ers are 0-4 when betting the Over for -4.4 Units / -100% ROI
    • 49ers are 4-0 when betting the Under for +4 Units / ROI

    Panthers Against the Spread (ATS) Record

    Against the spread this NFL season, the Panthers have gone 1-3 (-2.3 Units / -52.27% ROI).

    • Panthers are 1-3 when betting on the Moneyline for -2.45 Units / -53.85% ROI
    • Panthers are 1-3 when betting the Over for -2.35 Units / -52.81% ROI
    • Panthers are 3-1 when betting the Under for +1.9 Units / 43.68% ROI

    San Francisco 49ers: Keys to the Game vs. the Carolina Panthers

    The 49ers are 9-0 (1.000) when not throwing an interception since the 2021 season — tied for best in NFL. The Panthers have intercepted 12 passes since the 2021 season — tied for second-fewest in NFL.

    The 49ers are undefeated (8-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .536.

    The 49ers are undefeated (9-0) when not throwing an interception since the 2021 season — tied for best in NFL; League Avg: .651.

    The 49ers are 11-2 (.846) when scoring 22 or more points since the 2021 season — tied for 5th-best in NFL; League Avg: .727.

    Carolina Panthers: Keys to the Game vs. the San Francisco 49ers

    The Panthers are winless (0-5) when allowing more than 5 yards per rush since the 2021 season — worst in NFL; League Avg: .485.

    The Panthers are 1-8 (.111) when within 7 points entering the 4th quarter since the 2021 season — 2nd-worst in NFL; League Avg: .493.

    The Panthers are winless (0-8) when allowing 27 or more points since the 2021 season — tied for worst in NFL; League Avg: .195.

    The Panthers are winless (0-7) since Week 11 — worst in NFL; League Avg: .500.

    Additional Matchup Notes for San Francisco 49ers vs. Carolina Panthers

    The Panthers have run successful plays on just 35.0% of pass attempts this season — second-worst in NFL. 49ers have allowed successful plays on just 41.1% of pass attempts this season — fifth-best in NFL.

    The Panthers have been successful on just 39.2% of plays they have run since the 2021 season — tied for third-worst in NFL. 49ers have allowed their opponents to be successful on just 38.3% of plays since the 2021 season — third-best in NFL.

    The Panthers have scored on 0% of their drives in the first quarter this season — tied for worst in NFL. The 49ers defense has allowed scores on 8.3% of opponent drives in the first quarter this season — best in NFL.

    The 49ers allowed opponents to pressure their QB on 7.4% of pass attempts last week — second-best in NFL. The Panthers have pressured opposing QBs on just 6.2% of passing plays in Week 3 — worst in NFL.

    The 49ers have scored just 3.6 points per Red Zone drive this season — tied for third-worst in NFL. The Panthers have allowed just 3.2 points per Red Zone drive this season — tied for second-best in NFL.

    The 49ers are averaging 5.4 yards per carry on rushes to the left side of the field since the 2021 season — fourth-best in NFL. The Panthers have allowed 5.6 yards per carry when defending on rushes to the left since the 2021 season — third-worst in NFL.

    San Francisco 49ers Offense: Important Stats for Week 5

    The 49ers are averaging 20.0 drives per TD in the 2nd half this season — 2nd-worst Drives Per TD rate in NFL; League Avg: 4.8.

    The 49ers have thrown the ball 17% of the time (3 Pass Attempts/18 plays) on second and 4-7 yards to go this season — lowest in NFL; League Avg: 52%.

    The 49ers have started 4 drives inside their own 10 yard line in the 1st half this season — tied for most in NFL.

    The 49ers have not recorded a TD in 10 drives in close and late situations this season — tied for worst Drives Per TD rate in NFL; League Avg: 5.9.

    Carolina Panthers Offense: Important Stats for Week 5

    The Panthers are averaging 24.0 drives per TD in the 1st half this season — worst Drives Per TD rate in NFL; League Avg: 4.7.

    The Panthers are averaging 14.5 drives per TD in the 3rd quarter since the 2021 season — worst Drives Per TD rate in NFL; League Avg: 5.3.

    The Panthers have run successful plays on 29% of plays in the 3rd quarter this season — 2nd-worst in NFL; League Avg: 44%.

    The Panthers have scored on 10% of their drives in the 3rd quarter since the 2021 season — worst in NFL; League Avg: 30%.

    San Francisco 49ers Defense: Important Stats for Week 5

    The 49ers defense sacked opponents 7 times in Week 4 — most in NFL.

    The 49ers defense has allowed just 9.2 points per game to opposing offenses (37 points / 4 games) this season — best in NFL; League Avg: 20.9.

    The 49ers’ opponents have averaged 64.5 Passing Attempts per TD (129 Pass Attempts/2 Passing TDs) this season — best Pass Attempts Per TD rate in NFL; League Avg: 23.6.

    The 49ers defense has allowed scores on 18% of opponent drives this season — best in NFL; League Avg: 36%.

    Carolina Panthers Defense: Important Stats for Week 5

    The Panthers defense sacked opposing QBs just once on 66 pass attempts in the red zone last season — worst attempts per sack rate in NFL; League Avg: 17.3.

    Only 12% of the plays ran against the Panthers were in the red zone in the 4th quarter last season — 2nd-best in NFL; League Avg: 17%.

    The Panthers defense allowed successful plays on 32% of plays in the 1st quarter last season — best in NFL; League Avg: 43%.

    The Panthers defense has allowed successful plays on 32% of pass attempts in the 1st quarter since the 2021 season — best in NFL; League Avg: 47%.

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    Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

    Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.