- The 49ers (2-2) are -6.5 point favorites vs the Panthers (1-3)
- Total (Over/Under): 39.5 points
- Watch the game on CBS
The San Francisco 49ers (2-2) visit Bank of America Stadium to take on the Carolina Panthers (1-3) on Oct. 9. Kickoff is scheduled for 4:05pm EDT in Charlotte.
The 49ers are betting favorites in Week 5, with the spread sitting at -6.5 (-110).
The 49ers vs. Panthers Over/Under is 39.5 total points for the game.
Bet now on Panthers vs 49ers & all NFL games with BetMGM
49ers vs. Panthers Odds, Spread, Over/Under Week 5
| Spread | Total (O/U) | Moneyline | |
| 49ers | -6.5 -110 | 39.5 -110 | -275 |
| Panthers | +6.5 -110 | 39.5 -110 | +220 |
49ers vs. Panthers Prediction for Week 5
Based on recent trends, the winning team model predicts the 49ers will win this Week 5 game with 74.5% confidence.
49ers vs Panthers Spread Prediction for Week 5
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 5 with 60.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Panthers, plus offensive & defensive matchups, recent games and key player performances this season.
Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 5, looking at profitable historical betting trends:
Best Panthers Player Prop Best Bets Today
And here are some top NFL player prop bets for Panthers players for Week 5, looking at profitable historical betting trends:
First Touchdown Scorer Bet for Panthers vs 49ers
| Player Name | 1st TD Odds |
|---|---|
| Deebo Samuel | +500 |
| Jeff Wilson | +600 |
| Christian McCaffrey | +700 |
| Brandon Aiyuk | +900 |
| George Kittle | +900 |
Anytime Touchdown Scorer Bet for Panthers vs 49ers
| Player Name | Anytime TD Odds |
|---|---|
| Christian McCaffrey | -115 |
| Deebo Samuel | -115 |
| Jeff Wilson | +100 |
| Brandon Aiyuk | +160 |
| DJ Moore | +170 |
Receiving Props: Total Receiving Yards for Panthers vs 49ers
| Player Name | Over | Under |
|---|---|---|
| DJ Moore | 49.5 -115 | 49.5 -110 |
| Deebo Samuel | 55.5 -115 | 55.5 -115 |
| Brandon Aiyuk | 45.5 -115 | 45.5 -115 |
| Christian McCaffrey | 36.5 -110 | 36.5 -115 |
| Robby Anderson | 35.5 -115 | 35.5 -110 |
Rushing Props: Total Rushing Yards for Panthers vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Christian McCaffrey | 52.5 -115 | 52.5 -115 |
| Baker Mayfield | 7.5 -120 | 7.5 -110 |
| Jeff Wilson Jr. | 68.5 -115 | 68.5 -110 |
| Deebo Samuel | 22.5 -110 | 22.5 -115 |
| Jimmy Garoppolo | 1.5 -110 | 1.5 -120 |
49ers Betting Trends: ATS, Moneyline, Over/Under
Panthers Betting Trends: ATS, Moneyline, Over/Under
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 2-2 (-0.2 Units / -4.55% ROI).
- 49ers are 2-2 when betting on the Moneyline for -1.85 Units / -20.67% ROI
- 49ers are 0-4 when betting the Over for -4.4 Units / -100% ROI
- 49ers are 4-0 when betting the Under for +4 Units / ROI
Panthers Against the Spread (ATS) Record
Against the spread this NFL season, the Panthers have gone 1-3 (-2.3 Units / -52.27% ROI).
- Panthers are 1-3 when betting on the Moneyline for -2.45 Units / -53.85% ROI
- Panthers are 1-3 when betting the Over for -2.35 Units / -52.81% ROI
- Panthers are 3-1 when betting the Under for +1.9 Units / 43.68% ROI
San Francisco 49ers: Keys to the Game vs. the Carolina Panthers
The 49ers are 9-0 (1.000) when not throwing an interception since the 2021 season — tied for best in NFL. The Panthers have intercepted 12 passes since the 2021 season — tied for second-fewest in NFL.
The 49ers are undefeated (8-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .536.
The 49ers are undefeated (9-0) when not throwing an interception since the 2021 season — tied for best in NFL; League Avg: .651.
The 49ers are 11-2 (.846) when scoring 22 or more points since the 2021 season — tied for 5th-best in NFL; League Avg: .727.
Carolina Panthers: Keys to the Game vs. the San Francisco 49ers
The Panthers are winless (0-5) when allowing more than 5 yards per rush since the 2021 season — worst in NFL; League Avg: .485.
The Panthers are 1-8 (.111) when within 7 points entering the 4th quarter since the 2021 season — 2nd-worst in NFL; League Avg: .493.
The Panthers are winless (0-8) when allowing 27 or more points since the 2021 season — tied for worst in NFL; League Avg: .195.
The Panthers are winless (0-7) since Week 11 — worst in NFL; League Avg: .500.
Additional Matchup Notes for San Francisco 49ers vs. Carolina Panthers
The Panthers have run successful plays on just 35.0% of pass attempts this season — second-worst in NFL. 49ers have allowed successful plays on just 41.1% of pass attempts this season — fifth-best in NFL.
The Panthers have been successful on just 39.2% of plays they have run since the 2021 season — tied for third-worst in NFL. 49ers have allowed their opponents to be successful on just 38.3% of plays since the 2021 season — third-best in NFL.
The Panthers have scored on 0% of their drives in the first quarter this season — tied for worst in NFL. The 49ers defense has allowed scores on 8.3% of opponent drives in the first quarter this season — best in NFL.
The 49ers allowed opponents to pressure their QB on 7.4% of pass attempts last week — second-best in NFL. The Panthers have pressured opposing QBs on just 6.2% of passing plays in Week 3 — worst in NFL.
The 49ers have scored just 3.6 points per Red Zone drive this season — tied for third-worst in NFL. The Panthers have allowed just 3.2 points per Red Zone drive this season — tied for second-best in NFL.
The 49ers are averaging 5.4 yards per carry on rushes to the left side of the field since the 2021 season — fourth-best in NFL. The Panthers have allowed 5.6 yards per carry when defending on rushes to the left since the 2021 season — third-worst in NFL.
San Francisco 49ers Offense: Important Stats for Week 5
The 49ers are averaging 20.0 drives per TD in the 2nd half this season — 2nd-worst Drives Per TD rate in NFL; League Avg: 4.8.
The 49ers have thrown the ball 17% of the time (3 Pass Attempts/18 plays) on second and 4-7 yards to go this season — lowest in NFL; League Avg: 52%.
The 49ers have started 4 drives inside their own 10 yard line in the 1st half this season — tied for most in NFL.
The 49ers have not recorded a TD in 10 drives in close and late situations this season — tied for worst Drives Per TD rate in NFL; League Avg: 5.9.
Carolina Panthers Offense: Important Stats for Week 5
The Panthers are averaging 24.0 drives per TD in the 1st half this season — worst Drives Per TD rate in NFL; League Avg: 4.7.
The Panthers are averaging 14.5 drives per TD in the 3rd quarter since the 2021 season — worst Drives Per TD rate in NFL; League Avg: 5.3.
The Panthers have run successful plays on 29% of plays in the 3rd quarter this season — 2nd-worst in NFL; League Avg: 44%.
The Panthers have scored on 10% of their drives in the 3rd quarter since the 2021 season — worst in NFL; League Avg: 30%.
San Francisco 49ers Defense: Important Stats for Week 5
The 49ers defense sacked opponents 7 times in Week 4 — most in NFL.
The 49ers defense has allowed just 9.2 points per game to opposing offenses (37 points / 4 games) this season — best in NFL; League Avg: 20.9.
The 49ers’ opponents have averaged 64.5 Passing Attempts per TD (129 Pass Attempts/2 Passing TDs) this season — best Pass Attempts Per TD rate in NFL; League Avg: 23.6.
The 49ers defense has allowed scores on 18% of opponent drives this season — best in NFL; League Avg: 36%.
Carolina Panthers Defense: Important Stats for Week 5
The Panthers defense sacked opposing QBs just once on 66 pass attempts in the red zone last season — worst attempts per sack rate in NFL; League Avg: 17.3.
Only 12% of the plays ran against the Panthers were in the red zone in the 4th quarter last season — 2nd-best in NFL; League Avg: 17%.
The Panthers defense allowed successful plays on 32% of plays in the 1st quarter last season — best in NFL; League Avg: 43%.
The Panthers defense has allowed successful plays on 32% of pass attempts in the 1st quarter since the 2021 season — best in NFL; League Avg: 47%.
Looking to place a bet on this game with a First Bet Offer up to $1,000? Bet now on Panthers vs 49ers and all NFL games with BetMGM
Bet on NFL Odds at BetMGM
At BetMGM, you can bet online with updated NFL betting odds. And with live sports betting, the best online sports betting and mobile sports betting (with the BetMGM Sportsbook app) experiences are at BetMGM.
