- The 49ers are -8.5 point favorites vs the Rams
- Total (Over/Under): 44.5 points
- Watch the game on FOX
The San Francisco 49ers (1-0) visit SoFi Stadium to take on the Los Angeles Rams (1-0) on Sep. 17. Kickoff is scheduled for 4:05pm EDT in Inglewood.
The 49ers are betting favorites in this Week 2 matchup, with the spread sitting at -7.5 (-105).
The 49ers vs. Rams Over/Under is 45.5 total points for the game.
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49ers vs. Rams Odds, Spread, Over/Under
| Â | Spread | Total (O/U) | Moneyline |
| 49ers | -7.5 -105 | 45.5 -110 | -350 |
| Rams | +7.5 -115 | 45.5 -110 | +260 |
49ers vs. Rams Prediction
Based on recent trends, the winning team model predicts the 49ers will win this Week 2 game with 71.0% confidence.
49ers vs Rams Spread Prediction
Based on recent against-the-spread trends, the model predicts the Rams will cover the spread with 60.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Rams, plus offensive & defensive matchups, recent games and key player performances this season.
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Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players this Week 2 game, looking at profitable historical betting trends:
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Longest Rush Over in his last 7 away games (+7.00 Units / 89% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
Best Rams Player Prop Best Bets Today
And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:
- Matthew Stafford has hit the Passing Yards Under in 8 of his last 10 games (+5.50 Units / 45% ROI)
- Ben Skowronek has hit the Receiving Yards Over in his last 4 games at home (+4.05 Units / 89% ROI)
- Matthew Stafford has hit the Rushing Yards Under in his last 4 games at home (+4.00 Units / 88% ROI)
- Tyler Higbee has hit the Receptions Over in his last 3 games (+3.35 Units / 100% ROI)
- Cam Akers has hit the Receiving Yards Under in 6 of his last 8 games (+3.30 Units / 30% ROI)
First Touchdown Scorer Bet for Rams vs 49ers
| Player Name | 1st TD Odds |
|---|---|
| Christian McCaffrey | +450 |
| Kyren Williams | +650 |
| Cam Akers | +750 |
| Puka Nacua | +900 |
| Deebo Samuel | +1000 |
Anytime Touchdown Scorer Bet for Rams vs 49ers
| Player Name | Anytime TD Odds |
|---|---|
| Christian McCaffrey | -190 |
| Brandon Aiyuk | +110 |
| Deebo Samuel | +120 |
| George Kittle | +125 |
| Kyren Williams | +130 |
Receiving Props: Total Receiving Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Jauan Jennings | 15.5 -115 | 15.5 -115 |
| Puka Nacua | 43.5 -120 | 43.5 -110 |
| Tutu Atwell | 41.5 -110 | 41.5 -120 |
| Tyler Higbee | 41.5 -110 | 41.5 -120 |
| Van Jefferson | 37.5 -110 | 37.5 -120 |
Rushing Props: Total Rushing Yards for Rams vs 49ers
| Player Name | Over | Under |
|---|---|---|
| Christian Mccaffrey | 70.5 -115 | 70.5 -115 |
| Brock Purdy | 7.5 -110 | 7.5 -120 |
| Cam Akers | 31.5 -115 | 31.5 -120 |
| Matthew Stafford | 3.5 -120 | 3.5 -110 |
| Eli Mitchell | 24.5 -120 | 24.5 -110 |
49ers Best Bets:
- The San Francisco 49ers have hit the 4Q Moneyline in 12 of their last 20 games (+7.20 Units / 22% ROI)
- The San Francisco 49ers have hit the 1H Game Total Over in 8 of their last 10 away games (+5.85 Units / 54% ROI)
- The San Francisco 49ers have hit the 2H Moneyline in 13 of their last 20 games (+5.85 Units / 16% ROI)
- The San Francisco 49ers have hit the 2Q Game Total Over in 13 of their last 20 games (+5.10 Units / 22% ROI)
- The San Francisco 49ers have covered the 2H Spread in 12 of their last 20 games (+4.45 Units / 20% ROI)
Rams Best Bets:
- The Los Angeles Rams have hit the 1H Game Total Over in 8 of their last 10 games at home (+5.90 Units / 54% ROI)
- The Los Angeles Rams have hit the 4Q Game Total Over in their last 5 games at home (+5.00 Units / 86% ROI)
- The Los Angeles Rams have hit the 3Q Game Total Under in their last 5 games at home (+5.00 Units / 80% ROI)
- The Los Angeles Rams have covered the 2H Spread in their last 4 games at home (+4.00 Units / 95% ROI)
- The Los Angeles Rams have hit the 2Q Game Total Over in 6 of their last 8 games at home (+3.85 Units / 43% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers went 1-0 (+1 Units / 90.91% ROI).
- 49ers are 1-0 when betting on the Moneyline for +1 Units / 83.33% ROI
- 49ers are 0-1 when betting the Over for -1.1 Units / -100% ROI
- 49ers are 1-0 when betting the Under for +1 Units / ROI
Rams Against the Spread (ATS) Record
Against the spread this NFL season, the Rams went 1-0 (+1 Units / 90.91% ROI).
- Rams are 1-0 when betting on the Moneyline for +1.8 Units / 180% ROI
- Rams are 0-1 when betting the Over for -1.1 Units / -100% ROI
- Rams are 1-0 when betting the Under for +1 Units / 90.91% ROI
San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams
The 49ers are 9-3 (.750) vs top 10 pass offenses since the 2021 season — 2nd-best in NFL; League Avg: .356.
The 49ers are undefeated (18-0) when not throwing an interception since the 2021 season — best in NFL; League Avg: .635.
The 49ers are 10-1 (.909) vs bottom 10 run offenses since the 2021 season — best in NFL; League Avg: .547.
The 49ers are undefeated (15-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .550.
Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers
The Rams are 2-8 (.200) when throwing at least 1 interception since the 2022 season — seventh-worst in NFL. The 49ers have intercepted 22 passes since the 2022 season — most in NFL.
The Rams were winless (0-8) when allowing an average of more than 5 yards on first down plays in the 2022 season — worst in NFL; League Avg: .439.
The Rams are winless (0-8) when allowing an average of more than 5 yards on first down plays since the 2022 season — worst in NFL; League Avg: .437.
The Rams were 1-7 (.125) when within 7 points entering the 4th quarter in the 2022 season — worst in NFL; League Avg: .497.
Additional Matchup Notes for San Francisco 49ers vs. Los Angeles Rams
The Rams have run successful plays on just 38.9% of rush attempts since the 2022 season — fourth-worst in NFL. 49ers have allowed successful plays on just 38.0% of rush attempts since the 2022 season — second-best in NFL.
Rams RBs have averaged just 1.6 yards after contact per carry since the 2022 season — tied for third-worst in NFL. The 49ers have allowed just 1.4 yards after contact per carry to RBs since the 2022 season — tied for second-best in NFL.
The Rams are averaging just 3.9 yards per carry since the 2022 season — fifth-worst in NFL. The 49ers have allowed just 3.6 yards per carry since the 2022 season — second-best in NFL.
The 49ers have run successful plays on 52.1% of pass attempts since the 2022 season — second-best in NFL. Rams have allowed successful plays on 50.2% of pass attempts since the 2022 season — fourth-worst in NFL.
The 49ers have run successful plays on 48.0% of pass attempts on their opponent’s side of the field since the 2022 season — fourth-best in NFL. Rams have allowed successful plays on 54.1% of pass attempts on their own side of the field since the 2022 season — second-worst in NFL.
The 49ers have run 16.3% offensive plays in the red zone since the 2022 season — fifth-best in NFL. Rams has allowed their opponent to run 16.7% of plays in the red zone since the 2022 season — worst in NFL.
San Francisco 49ers Offense: Important Stats
The 49ers had 6 TDs that were 20+ yards in the last 4 weeks of the regular season — most in NFL.
The 49ers went three and out on 14% of their drives in the 2022 season — best in NFL; League Avg: 21%.
The 49ers did not go three and out on any of their drives in Week 1 — tied for best in NFL; League Avg: 25%.
The 49ers have gone three and out on 13% of their drives since the 2022 season — best in NFL; League Avg: 22%.
Los Angeles Rams Offense: Important Stats
The Rams ran successful plays on 12% of plays in the 4th quarter in the last 4 weeks of the regular season — worst in NFL; League Avg: 39%.
The Rams have been flagged 67 times on offense since the 2021 season — 2nd-fewest in NFL.
The Rams ran successful plays on 0% of rush attempts in close and late situations in the last 4 weeks of the regular season — worst in NFL; League Avg: 41%.
The Rams ran successful plays on 6% of plays in close and late situations in the last 4 weeks of the regular season — worst in NFL; League Avg: 40%.
San Francisco 49ers Defense: Important Stats
The 49ers defense allowed scores on 26% of opponent drives in the 2022 season — best in NFL; League Avg: 36%.
The 49ers defense has allowed successful plays on 26% of rush attempts in the 1st quarter since the 2022 season — best in NFL; League Avg: 42%.
The 49ers defense has allowed scores on 25% of opponent drives since the 2022 season — best in NFL; League Avg: 36%.
The 49ers defense allowed successful plays on 27% of rush attempts in the 1st quarter in the 2022 season — best in NFL; League Avg: 42%.
Los Angeles Rams Defense: Important Stats
The Rams defense allowed successful plays on 62% of pass attempts in the 3rd quarter in the 2022 season — worst in NFL; League Avg: 46%.
The Rams defense allowed successful plays on 55% of pass attempts in the 2nd half in the 2022 season — worst in NFL; League Avg: 45%.
24% of the plays ran against the Rams were in the red zone in the 4th quarter in the 2022 season — 2nd-worst in NFL; League Avg: 15%.
The Rams defense allowed successful plays on 12% of pass attempts in the 2nd half in Week 1 — best in NFL; League Avg: 41%.
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