- The 49ers are -2.5 point favorites vs the Steelers
- Total (Over/Under): 41 points
- Watch the game on FOX
The San Francisco 49ers (0-0) visit Acrisure Stadium to take on the Pittsburgh Steelers (0-0) on Sep. 10. Kickoff is scheduled for 1:00pm EDT in Pittsburgh.
The 49ers are betting favorites in this Week 1 matchup, with the spread sitting at -2.5 (-110).
The 49ers vs. Steelers Over/Under is 41 total points for the game.
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49ers vs. Steelers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| 49ers | -2.5 -110 | 41 -110 | -145 |
| Steelers | +2.5 -110 | 41 -110 | +120 |
49ers vs. Steelers Prediction
Based on recent trends, the winning team model predicts the 49ers will win this Week 1 game with 57.0% confidence.
49ers vs Steelers Spread Prediction
Based on recent against-the-spread trends, the model predicts the Steelers will cover the spread with 51.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Steelers, plus offensive & defensive matchups, recent games and key player performances this season.
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Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players this Week 1 game, looking at profitable historical betting trends:
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Longest Rush Over in his last 7 away games (+7.00 Units / 89% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
Best Steelers Player Prop Best Bets Today
And here are some top NFL player prop bets for Steelers players for this matchup, looking at profitable historical betting trends:
- Kenny Pickett has hit the TD Passes Under in 9 of his last 10 games (+8.45 Units / 40% ROI)
- Kenny Pickett has hit the Interceptions Under in 9 of his last 11 games (+7.25 Units / 49% ROI)
- Kenny Pickett has hit the Completions Under in his last 5 games (+5.00 Units / 78% ROI)
- Kenny Pickett has hit the Pass Attempts Under in his last 5 games (+5.00 Units / 77% ROI)
- Kenny Pickett has hit the Rushing Yards Under in his last 5 games (+5.00 Units / 74% ROI)
First Touchdown Scorer Bet for Steelers vs 49ers
| Player Name | 1st TD Odds |
|---|---|
| Christian McCaffrey | +500 |
| Najee Harris | +750 |
| George Kittle | +900 |
| Brandon Aiyuk | +1000 |
| Deebo Samuel | +1000 |
Anytime Touchdown Scorer Bet for Steelers vs 49ers
| Player Name | Anytime TD Odds |
|---|---|
| Christian McCaffrey | -140 |
| Najee Harris | +105 |
| George Kittle | +150 |
| Brandon Aiyuk | +160 |
| Deebo Samuel | +160 |
49ers Best Bets:
- The San Francisco 49ers have hit the 2H Moneyline in 10 of their last 13 games (+7.80 Units / 29% ROI)
- The San Francisco 49ers have hit the 3Q Moneyline in 9 of their last 13 games (+6.50 Units / 28% ROI)
- The San Francisco 49ers have hit the 4Q Moneyline in 10 of their last 17 games (+6.45 Units / 23% ROI)
- The San Francisco 49ers have covered the 2H Spread in 9 of their last 13 games (+5.70 Units / 40% ROI)
- The San Francisco 49ers have hit the 2Q Game Total Over in 11 of their last 16 games (+5.35 Units / 29% ROI)
Steelers Best Bets:
- The Pittsburgh Steelers have hit the Moneyline in 12 of their last 20 games (+7.80 Units / 32% ROI)
- The Pittsburgh Steelers have covered the Spread in 13 of their last 20 games (+6.40 Units / 29% ROI)
- The Pittsburgh Steelers have hit the 2Q Game Total Over in 10 of their last 15 games (+6.25 Units / 35% ROI)
- The Pittsburgh Steelers have hit the 1H Moneyline in 11 of their last 20 games (+6.10 Units / 26% ROI)
- The Pittsburgh Steelers have hit the 2H Moneyline in 6 of their last 8 games at home (+5.80 Units / 55% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL preseason, the 49ers went 1-2 (-1.25 Units / -36.76% ROI).
- 49ers are 1-2 when betting on the Moneyline for -4.3 Units / -64.18% ROI
- 49ers are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
- 49ers are 1-2 when betting the Under for -1.2 Units / ROI
Steelers Against the Spread (ATS) Record
Against the spread this NFL preseason, the Steelers went 3-0 (+3 Units / 90.91% ROI).
- Steelers are 3-0 when betting on the Moneyline for +3.05 Units / 58.1% ROI
- Steelers are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
- Steelers are 2-1 when betting the Under for +0.9 Units / 27.27% ROI
San Francisco 49ers: Keys to the Game vs. the Pittsburgh Steelers
The 49ers were undefeated (8-0) when the opposing team converts less than 55% of its red zone chances into touchdowns in the 2022 season — best in NFL; League Avg: .559.
The 49ers were 12-3 (.800) when allowing less than 5 yards per rush in the 2022 season — 2nd-best in NFL; League Avg: .519.
The 49ers are 10-1 (.909) vs bottom 10 run offenses since the 2021 season — best in NFL; League Avg: .546.
The 49ers are undefeated (14-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .547.
Pittsburgh Steelers: Keys to the Game vs. the San Francisco 49ers
The Steelers were 1-6 (.143) when throwing at least 1 interception last season — tied for fourth-worst in NFL. The 49ers intercepted 20 passes last season — tied for most in NFL.
The Steelers were winless (0-5) when allowing 22 or more points in the 2022 season — tied for worst in NFL; League Avg: .273.
The Steelers were winless (0-5) when committing 2 or more turnovers in the 2022 season — tied for worst in NFL; League Avg: .296.
The Steelers are winless (0-5) when allowing more than 50% of third down conversions opportunities since the 2021 season — tied for worst in NFL; League Avg: .278.
Additional Matchup Notes for San Francisco 49ers vs. Pittsburgh Steelers
The Steelers averaged just 3.9 yards per carry on 1st Down last season — tied for fourth-worst in NFL. The 49ers allowed just 3.4 yards per carry on first down last season — second-best in NFL.
The Steelers had a third down conversion rate of 64.7% in the second half in the last 4 weeks of the regular season — best in NFL. The 49ers defense allowed a third down conversion rate of 45.5% in the second half in the last 4 weeks of the regular season — fifth-worst in NFL.
The Steelers were 1-6 (.143) when throwing at least 1 interception last season — tied for fourth-worst in NFL. The 49ers intercepted 20 passes last season — tied for most in NFL.
The 49ers threw 30 touchdown passes last season — tied for fourth-most in NFL. The Steelers allowed 29 passing TDs last season — tied for second-most in NFL.
The 49ers allowed opponents to pressure their QB on 17.2% of pass attempts last season — second-best in NFL. The Steelers had pressured opposing QBs on just 19.2% of passing plays last season — tied for fourth-worst in NFL.
The 49ers threw for 20+ yards on 56 of 512 attempts last season — third-best in NFL. The Steelers allowed 20+ yards on 10.1% of attempts last season — fourth-worst in NFL.
San Francisco 49ers Offense: Important Stats
The 49ers had 6 TDs that were 20+ yards in the last 4 weeks of the regular season — most in NFL.
The 49ers went three and out on 14% of their drives in the 2022 season — best in NFL; League Avg: 21%.
The 49ers had 12 TDs that were 20+ yards in the last 8 weeks of the regular season — tied for most in NFL.
The 49ers have averaged 8.3 yards per attempt (6,115 yards/736 attempts) on Early Downs since the 2021 season — best in NFL; League Avg: 7.1.
Pittsburgh Steelers Offense: Important Stats
The Steelers averaged 14.7 drives per TD in the 3rd quarter in the 2022 season — worst Drives Per TD rate in NFL; League Avg: 5.4.
The Steelers are averaging 10.6 drives per TD in the 3rd quarter since the 2021 season — worst Drives Per TD rate in NFL; League Avg: 5.3.
The Steelers threw 0.7 TD passes per game (12/17) in the 2022 season — worst in NFL; League Avg: 1.4.
12 of the Steelers offense’s 28 (43%) TDs came through the air in the 2022 season — lowest in NFL; League Avg: 60%.
San Francisco 49ers Defense: Important Stats
The 49ers defense allowed just 15.2 points per game to opposing offenses (259 points / 17 games) in the 2022 season — best in NFL; League Avg: 20.8.
The 49ers defense allowed successful plays on 27% of rush attempts in the 1st quarter in the 2022 season — best in NFL; League Avg: 42%.
The 49ers defense allowed scores on 26% of opponent drives in the 2022 season — best in NFL; League Avg: 36%.
The 49ers defense allowed 16.4 Points per Game (279/17) in the 2022 season — worst in NFL; League Avg: 21.8.
Pittsburgh Steelers Defense: Important Stats
The Steelers defense allowed 6 rushing TDs on 61 carries (10.2 Carries Per TD) in the red zone in the 2022 season — best Carries Per TD rate in NFL; League Avg: 5.4.
The Steelers have been flagged 16 times for 10+ yards on defense since the 2021 season — fewest in NFL.
The Steelers defense have forced three and outs on 27% of opponent drives in the 4th quarter since the 2021 season — best in NFL; League Avg: 15%.
The Steelers defense allowed 7 rushing TDs in the 2022 season — tied for fewest in NFL.
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