49ers vs Texans Prediction, Odds & Best Prop Bets – NFL, Week 8

BetMGM Betting Oct 26, 2025, 10:19 AM

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A detail view of a Houston Texans helmet on the sideline prior to an NFL preseason football game against the Carolina Panthers, Saturday, Aug. 16, 2025, in Houston. (AP Photo/Maria Lysaker)

(AP Photo/Maria Lysaker)

The Texans are -1.5 point favorites vs the 49ers
Total (Over/Under): 41.5 points
Watch this game on FOX

The San Francisco 49ers (5-2-0) visit NRG Stadium to take on the Houston Texans (2-4-0) on Oct. 26. Kickoff is scheduled for 1:00pm EDT in Houston, TX.

The Texans are betting favorites in this matchup, with the spread sitting at -1.5 (-105).

The 49ers vs. Texans Over/Under is 41.5 total points for the game.

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49ers vs. Texans Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
49ers	+49 -115	41.5 -110	-102
Texans	-1.5 -105	41.5 -110	-118

49ers vs. Texans Prediction

The winning team model predicts the 49ers will win this game with 52.8% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

49ers vs Texans Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 52.7% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for 49ers players this game, looking at profitable historical betting trends:

Best 49ers Player Prop Bets Today

Christian McCaffrey has hit the Rushing Yards Under in 9 of his last 11 games (+6.75 Units / 54% ROI)
Christian McCaffrey has hit the Receiving Yards Over in 9 of his last 11 games (+6.60 Units / 51% ROI)
Demarcus Robinson has hit the Receptions Under in 11 of his last 15 games (+6.30 Units / 31% ROI)
Brian Robinson has hit the Receptions Under in 10 of his last 14 games (+5.80 Units / 31% ROI)
Kendrick Bourne has hit the Receptions Over in 6 of his last 7 away games (+5.35 Units / 69% ROI)

And here are some top NFL player prop bets for Texans players for this matchup, looking at profitable historical betting trends:

Best Texans Player Prop Best Bets Today

Ka’imi Fairbairn has hit the Field Goals Over in 14 of his last 17 games (+10.15 Units / 39% ROI)
Nick Chubb has hit the Receiving Yards Under in 10 of his last 13 games (+6.45 Units / 43% ROI)
Nico Collins has hit the Receptions Under in 10 of his last 14 games (+5.20 Units / 30% ROI)
C.J. Stroud has hit the Carries Over in 11 of his last 17 games (+4.75 Units / 23% ROI)
Xavier Hutchinson has hit the Receptions Over in 8 of his last 11 games (+4.20 Units / 28% ROI)

49ers Best Bets:

The San Francisco 49ers have covered the 1Q Spread in 15 of their last 20 games (+9.40 Units / 39% ROI)
The San Francisco 49ers have hit the 1Q Moneyline in 10 of their last 19 games (+6.85 Units / 29% ROI)
The San Francisco 49ers have hit the 3Q Game Total Over in 12 of their last 17 games (+6.20 Units / 30% ROI)
The San Francisco 49ers have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)
The San Francisco 49ers have hit the 2Q Game Total Over in 7 of their last 9 away games (+4.75 Units / 45% ROI)

Texans Best Bets:

The Houston Texans have hit the 1Q Game Total Over in 12 of their last 20 games (+5.00 Units / 23% ROI)
The Houston Texans have hit the 2Q Moneyline in 11 of their last 18 games (+3.70 Units / 15% ROI)
The Houston Texans have covered the 1H Spread in 13 of their last 21 games (+3.55 Units / 14% ROI)
The Houston Texans have hit the 1H Moneyline in 13 of their last 21 games (+3.20 Units / 11% ROI)
The Houston Texans have hit the 2H Moneyline in 4 of their last 5 games at home (+3.14 Units / 46% ROI)

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 4-3 (+0.7 Units / 9.09% ROI).

49ers are 5-2 when betting on the Moneyline for +4.95 Units / 55.62% ROI
49ers are 4-3 when betting the Over for +0.7 Units / 9.09% ROI
49ers are 3-4 when betting the Under for -1.4 Units / ROI

Texans Against the Spread (ATS) Record

Against the spread this NFL season, the Texans are 2-4 (-2.45 Units / -36.84% ROI).

Texans are 2-4 when betting on the Moneyline for -2.5 Units / -25.51% ROI
Texans are 2-4 when betting the Over for -2.4 Units / -36.36% ROI
Texans are 4-2 when betting the Under for +1.8 Units / 27.27% ROI

San Francisco 49ers: Keys to the Game vs. the Houston Texans

The Texans have run 25% of their plays in their opponent’s territory in the 3rd quarter this season — worst in NFL; League Avg: 44%.

The Texans have run successful plays on 24% of plays against a light front this season — worst in NFL; League Avg: 38%.

The Texans have run successful plays on 31% of rush attempts in the 3rd quarter this season — 2nd-worst in NFL; League Avg: 46%.

The Texans have scored on 12% of their drives (2/16) in the 3rd quarter this season — worst in NFL; League Avg: 33%.

Houston Texans: Keys to the Game vs. the San Francisco 49ers

The 49ers have targeted RBs 28% of the time (74 Pass Attempts/267 plays) this season — highest in NFL; League Avg: 17%.

The 49ers have a third down conversion rate of 78% against open coverage this season — best in NFL; League Avg: 52%.

The 49ers have a third down conversion rate of 47% this season — 2nd-best in NFL; League Avg: 39%.

The 49ers have gone three and out on 14% of their drives since the 2024 season — 2nd-best in NFL; League Avg: 21%.

Additional Matchup Notes for San Francisco 49ers vs. Houston Texans