- The Bills are -7.5 point favorites vs the Panthers
- Total (Over/Under): 45.5 points
- Watch this game on FOX
The Buffalo Bills (4-2-0) visit Bank of America Stadium to take on the Carolina Panthers (4-3-0) on Oct. 26. Kickoff is scheduled for 1:00pm EDT in Charlotte, NC.
The Bills are betting favorites in this matchup, with the spread sitting at -7.5 (-105).
The Bills vs. Panthers Over/Under is 45.5 total points for the game.
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Bills vs. Panthers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Bills | -7.5 -105 | 45.5 -110 | -400 |
| Panthers | +7.5 -115 | 45.5 -110 | 310 |
Bills vs. Panthers Prediction
The winning team model predicts the Bills will win this game with 77.6% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Bills vs Panthers Spread Prediction
Based on recent against-the-spread trends, the model predicts the Panthers will cover the spread with 57.1% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Bills players this game, looking at profitable historical betting trends:
Best Bills Player Prop Bets Today
- Ray Davis has hit the Rushing Yards Under in 12 of his last 15 games (+8.70 Units / 51% ROI)
- Josh Palmer has hit the Receiving Yards Over in 12 of his last 16 games (+7.30 Units / 39% ROI)
- Josh Allen has hit the TD Passes Over in 13 of his last 18 games (+6.90 Units / 30% ROI)
- Elijah Moore has hit the Receptions Under in 9 of his last 12 games (+6.65 Units / 44% ROI)
- Ray Davis has hit the Receptions Under in 5 of his last 6 games (+5.06 Units / 82% ROI)
And here are some top NFL player prop bets for Panthers players for this matchup, looking at profitable historical betting trends:
Best Panthers Player Prop Best Bets Today
- Rico Dowdle has hit the Rushing Yards Over in 13 of his last 17 games (+8.40 Units / 42% ROI)
- Bryce Young has hit the Completions Under in 12 of his last 16 games (+7.90 Units / 44% ROI)
- Bryce Young has hit the TD Passes Over in 11 of his last 17 games (+7.60 Units / 37% ROI)
- Rico Dowdle has hit the Carries Over in 11 of his last 14 games (+7.55 Units / 45% ROI)
- Bryce Young has hit the Pass Attempts Under in 7 of his last 9 games at home (+4.85 Units / 47% ROI)
First Touchdown Scorer Bet for Panthers vs Bills
| Player Name | 1st TD Odds |
|---|---|
| Josh Allen (BUF) | +650 |
| James Cook (Buf) | +450 |
| Ray Davis (BUF) | +5000 |
| Ty Johnson (BUF) | +3300 |
| Keon Coleman (BUF) | +1200 |
Receiving Props: Total Receiving Yards for Panthers vs Bills
| Player Name | Over | Under |
|---|---|---|
| Xavier Legette (CAR) | 33.5 -118 | 33.5 -110 |
| Tetairoa McMillan (CAR) | 54.5 -115 | 54.5 -115 |
| James Cook (BUF) | 13.5 -115 | 13.5 -115 |
| Khalil Shakir (BUF) | 47.5 -115 | 47.5 -118 |
| Keon Coleman (BUF) | 43.5 -115 | 43.5 -115 |
Rushing Props: Total Rushing Yards for Panthers vs Bills
| Player Name | Over | Under |
|---|---|---|
| Rico Dowdle (CAR) | 48.5 -115 | 48.5 -115 |
| Josh Allen (BUF) | 30.5 -118 | 30.5 -110 |
| James Cook (BUF) | 74.5 -115 | 74.5 -115 |
| Chuba Hubbard (CAR) | 44.5 -115 | 44.5 -115 |
Bills Best Bets:
- The Buffalo Bills have hit the 2H Moneyline in 14 of their last 17 games (+12.02 Units / 35% ROI)
- The Buffalo Bills have covered the 2H Spread in 15 of their last 19 games (+10.37 Units / 46% ROI)
- The Buffalo Bills have hit the 3Q Moneyline in 12 of their last 19 games (+8.45 Units / 25% ROI)
- The Buffalo Bills have hit the 1H Team Total Over in 8 of their last 9 away games (+6.80 Units / 60% ROI)
- The Buffalo Bills have hit the 4Q Game Total Over in 13 of their last 19 games (+6.35 Units / 29% ROI)
Panthers Best Bets:
- The Carolina Panthers have covered the 3Q Spread in 8 of their last 9 games at home (+7.05 Units / 63% ROI)
- The Carolina Panthers have hit the 2H Moneyline in 8 of their last 16 games (+6.58 Units / 40% ROI)
- The Carolina Panthers have hit the 2Q Game Total Over in 12 of their last 17 games (+6.50 Units / 35% ROI)
- The Carolina Panthers have hit the 2H Game Total Over in 7 of their last 8 games at home (+5.93 Units / 66% ROI)
- The Carolina Panthers have hit the Game Total Over in 13 of their last 20 games (+5.30 Units / 24% ROI)
Bills Against the Spread (ATS) Record
Against the spread this NFL season, the Bills are 2-4 (-2.4 Units / -36.36% ROI).
- Bills are 4-2 when betting on the Moneyline for -2.3 Units / -7.81% ROI
- Bills are 3-3 when betting the Over for -0.3 Units / -4.55% ROI
- Bills are 3-3 when betting the Under for -0.3 Units / ROI
Panthers Against the Spread (ATS) Record
Against the spread this NFL season, the Panthers are 5-2 (+2.8 Units / 35.67% ROI).
- Panthers are 4-3 when betting on the Moneyline for +2.25 Units / 31.69% ROI
- Panthers are 4-3 when betting the Over for +0.7 Units / 9.09% ROI
- Panthers are 3-4 when betting the Under for -1.4 Units / -18.18% ROI
Buffalo Bills: Keys to the Game vs. the Carolina Panthers
The Panthers defense has allowed a passer rating of just 3.2 on contested throws (22 Pass Attempts) this season — best in NFL; League Avg: 75.4.
The Panthers defense has allowed successful plays on 11% of pass attempts with tight coverage this season — 2nd-best in NFL; League Avg: 19%.
The Panthers defense have allowed -1.12 epa per play on contested throws since Week 4 — 2nd-best in NFL; League Avg: -0.04.
The Panthers defense has allowed a passer rating of just 0.0 on contested throws (13 Pass Attempts) since Week 4 — best in NFL; League Avg: 80.6.
Carolina Panthers: Keys to the Game vs. the Buffalo Bills
The Bills have scored 5 TDs on first drive of the game this season — most in NFL.
The Bills have run successful plays on 60% of plays in the 3rd quarter this season — 3rd-best in NFL; League Avg: 46%.
The Bills have run successful plays on 58% of rush attempts in the 2nd half this season — best in NFL; League Avg: 43%.
The Bills averaged 0.26 epa per play on motion plays last season — best in NFL; League Avg: 0.01.
Additional Matchup Notes for Buffalo Bills vs. Carolina Panthers
The Bills have scored 5 TDs on first drive of the game this season — most in NFL.
The Bills have run successful plays on 60% of plays in the 3rd quarter this season — 3rd-best in NFL; League Avg: 46%.
The Bills have run successful plays on 58% of rush attempts in the 2nd half this season — best in NFL; League Avg: 43%.
The Bills averaged 0.26 epa per play on motion plays last season — best in NFL; League Avg: 0.01.
The Panthers defense has allowed a passer rating of just 3.2 on contested throws (22 Pass Attempts) this season — best in NFL; League Avg: 75.4.
The Panthers defense has allowed successful plays on 11% of pass attempts with tight coverage this season — 2nd-best in NFL; League Avg: 19%.
The Panthers defense have allowed -1.12 epa per play on contested throws since Week 4 — 2nd-best in NFL; League Avg: -0.04.
The Panthers defense has allowed a passer rating of just 0.0 on contested throws (13 Pass Attempts) since Week 4 — best in NFL; League Avg: 80.6.
Buffalo Bills Offense: Important Stats
The Panthers defense has allowed a passer rating of just 3.2 on contested throws (22 Pass Attempts) this season — best in NFL; League Avg: 75.4.
The Panthers defense has allowed successful plays on 11% of pass attempts with tight coverage this season — 2nd-best in NFL; League Avg: 19%.
The Panthers defense have allowed -1.12 epa per play on contested throws since Week 4 — 2nd-best in NFL; League Avg: -0.04.
The Panthers defense has allowed a passer rating of just 0.0 on contested throws (13 Pass Attempts) since Week 4 — best in NFL; League Avg: 80.6.
Carolina Panthers Offense: Important Stats
The Bills have scored 5 TDs on first drive of the game this season — most in NFL.
The Bills have run successful plays on 60% of plays in the 3rd quarter this season — 3rd-best in NFL; League Avg: 46%.
The Bills have run successful plays on 58% of rush attempts in the 2nd half this season — best in NFL; League Avg: 43%.
The Bills averaged 0.26 epa per play on motion plays last season — best in NFL; League Avg: 0.01.
Buffalo Bills Defense: Important Stats
The Panthers defense has allowed a passer rating of just 3.2 on contested throws (22 Pass Attempts) this season — best in NFL; League Avg: 75.4.
The Panthers defense has allowed successful plays on 11% of pass attempts with tight coverage this season — 2nd-best in NFL; League Avg: 19%.
The Panthers defense have allowed -1.12 epa per play on contested throws since Week 4 — 2nd-best in NFL; League Avg: -0.04.
The Panthers defense has allowed a passer rating of just 0.0 on contested throws (13 Pass Attempts) since Week 4 — best in NFL; League Avg: 80.6.
Carolina Panthers Defense: Important Stats
The Bills have scored 5 TDs on first drive of the game this season — most in NFL.
The Bills have run successful plays on 60% of plays in the 3rd quarter this season — 3rd-best in NFL; League Avg: 46%.
The Bills have run successful plays on 58% of rush attempts in the 2nd half this season — best in NFL; League Avg: 43%.
The Bills averaged 0.26 epa per play on motion plays last season — best in NFL; League Avg: 0.01.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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