- The Chargers are -11 point favorites vs the Cardinals
- Total (Over/Under): 46.5 points
- Watch this game on CBS
The Arizona Cardinals (0-0-0) visit SoFi Stadium to take on the Los Angeles Chargers (0-0-0) on Sep. 13. Kickoff is scheduled for 4:25 pm in Inglewood, CA.
The Chargers are betting favorites in this matchup, with the spread sitting at -11 (+110).
The Cardinals vs. Chargers Over/Under is 46.5 total points for the game.
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Cardinals vs. Chargers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Cardinals | +11 -145 | 46.5 +100 | +400 |
| Chargers | -11 +110 | 46.5 -135 | -525 |
Cardinals vs. Chargers Prediction
The winning team model predicts the Chargers will win this game with 74.6% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Cardinals vs Chargers Spread Prediction
Based on recent against-the-spread trends, the model predicts the Chargers will cover the spread with 69.9% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Cardinals players this game, looking at profitable historical betting trends:
Best Cardinals Player Prop Bets Today
- Jacoby Brissett has hit the TD Passes Over in 10 of his last 12 games (+10.65 Units / 79% ROI)
- Jacoby Brissett has hit the Passing Yards Over in 10 of his last 12 games (+7.70 Units / 56% ROI)
- Elijah Higgins has hit the Receptions Over in 7 of his last 10 games (+5.90 Units / 53% ROI)
- Kendrick Bourne has hit the Receptions Under in 7 of his last 8 games (+5.55 Units / 50% ROI)
- Michael Wilson has hit the Longest Reception Over in 9 of his last 12 games (+5.55 Units / 40% ROI)
And here are some top NFL player prop bets for Chargers players for this matchup, looking at profitable historical betting trends:
Best Chargers Player Prop Best Bets Today
- Justin Herbert has hit the Pass Attempts Under in 9 of his last 10 games (+7.80 Units / 67% ROI)
- Justin Herbert has hit the Longest Rush Over in 11 of his last 14 games (+7.70 Units / 47% ROI)
- Ladd McConkey has hit the Receiving Yards Under in 12 of his last 16 games (+7.45 Units / 41% ROI)
- Ladd McConkey has hit the Receptions Under in 8 of his last 9 games (+7.35 Units / 72% ROI)
- Justin Herbert has hit the Interceptions Over in 11 of his last 15 games (+7.30 Units / 46% ROI)
First Touchdown Scorer Bet for Chargers vs Cardinals
| Player Name | 1st TD Odds |
|---|---|
| Omarion Hampton | +375 |
| Ladd McConkey | +800 |
| Jeremiyah Love | +800 |
| Quentin Johnston | +950 |
| Trey McBride | +1200 |
Anytime Touchdown Scorer Bet for Chargers vs Cardinals
| Player Name | Anytime TD Odds |
|---|---|
| Omarion Hampton | -165 |
| Ladd McConkey | +130 |
| Quentin Johnston | +140 |
| Jeremiyah Love | +145 |
| Trey McBride | +185 |
Receiving Props: Total Receiving Yards for Chargers vs Cardinals
| Player Name | Over | Under |
|---|---|---|
| Trey McBride | 58.5 -115 | 58.5 -115 |
| Ladd McConkey | 54.5 -115 | 54.5 -115 |
| Marvin Harrison Jr. | 47.5 -115 | 47.5 -115 |
| Quentin Johnston | 43.5 -115 | 43.5 -115 |
| Michael Wilson | 41.5 -111 | 41.5 -118 |
Rushing Props: Total Rushing Yards for Chargers vs Cardinals
| Player Name | Over | Under |
|---|---|---|
| Jeremiyah Love | 39.5 -115 | 39.5 -115 |
| Justin Herbert | 19.5 -120 | 19.5 -111 |
| Jacoby Brissett | 9.5 -115 | 9.5 -115 |
Cardinals Best Bets:
- The Arizona Cardinals have hit the 4Q Game Total Over in 12 of their last 16 games (+7.55 Units / 42% ROI)
- The Arizona Cardinals have hit the 2Q Game Total Over in 9 of their last 11 games (+6.70 Units / 52% ROI)
- The Arizona Cardinals have hit the 3Q Moneyline in 5 of their last 8 away games (+6.35 Units / 78% ROI)
- The Arizona Cardinals have covered the 3Q Spread in 7 of their last 8 away games (+5.85 Units / 57% ROI)
- The Arizona Cardinals have hit the 3Q Game Total Over in 9 of their last 12 games (+5.25 Units / 36% ROI)
Chargers Best Bets:
- The Los Angeles Chargers have hit the 1H Team Total Under in 12 of their last 18 games (+7.10 Units / 36% ROI)
- The Los Angeles Chargers have hit the 2Q Moneyline in 4 of their last 5 games (+5.85 Units / 108% ROI)
- The Los Angeles Chargers have hit the 3Q Game Total Under in 8 of their last 10 games (+5.55 Units / 46% ROI)
- The Los Angeles Chargers have covered the 3Q Spread in 7 of their last 9 games (+5.15 Units / 46% ROI)
- The Los Angeles Chargers have hit the 2H Moneyline in 9 of their last 13 games (+5.05 Units / 25% ROI)
Arizona Cardinals: Keys to the Game vs. the Los Angeles Chargers
The Cardinals were 1-8 (.111) when throwing at least 1 interception last season — T-4th-lowest in NFL. The Chargers intercepted 19 passes last season — T-3rd-most in NFL.
The Cardinals were 1-13 (.071) when making less than 3 explosive runs in a game last season — worst in NFL; League Avg: .425.
The Cardinals were 1-11 (.083) when allowing an average of more than 5 yards on first down plays last season — worst in NFL; League Avg: .418.
The Cardinals were 2-8 (.200) when within 7 points at the two minute warning last season — T-4th-worst in NFL; League Avg: .496.
Los Angeles Chargers: Keys to the Game vs. the Arizona Cardinals
The Chargers were 4-1 (.800) when allowing less than 3 sacks last season — T-5th-best in NFL. The Cardinals averaged just 1.8 sacks per game over that time span — T-3rd-lowest in NFL.
The Chargers were undefeated (7-0) when allowing less than 10 rushes of four or more yards last season — T-best in NFL; League Avg: .718.
The Chargers were 10-4 (.714) when allowing less than 5 explosive passes last season — 10th-best in NFL; League Avg: .559.
The Chargers are 0-4 (.000) when allowing more than 50% of third down conversions opportunities (T-lowest in NFL) and 21-6 (.778) when allowing less than 50% of third down conversions opportunities since the 2024 season (4th-best in NFL).
Additional Matchup Notes for Arizona Cardinals vs. Los Angeles Chargers
The Chargers were successful on 51.3% of pass attempts with motion last season — 5th-best in NFL. The Cardinals pressured opposing QBs on 18.8% of pass attempts against motion last season — 5th-lowest in NFL.
The Chargers went three and out on 10.2% of their drives in the fourth quarter last season — 4th-best in NFL. The Cardinals forced three and outs on 6.8% of opponent drives in the 4th quarter last season — lowest in NFL.
The Chargers were 4-1 (.800) when allowing less than 3 sacks last season — T-5th-best in NFL. The Cardinals averaged just 1.8 sacks per game over that time span — T-3rd-lowest in NFL.
Cardinals TEs averaged 12.8 targets per game last season — highest in NFL. The Chargers allowed just 4.1 receptions per game to TEs last season — T-3rd-lowest in NFL.
The Cardinals have averaged just -0.56 epa per play against tight coverage since the 2024 season — 5th-lowest in NFL. The Chargers have allowed just -0.56 epa per play with tight coverage since the 2024 season — 5th-best in NFL.
The Cardinals were 1-8 (.111) when throwing at least 1 interception last season — T-4th-lowest in NFL. The Chargers intercepted 19 passes last season — T-3rd-most in NFL.
Arizona Cardinals Offense: Important Stats
The Cardinals ran the ball on 34% of plays (363 carries/1,074 plays) last season — lowest in NFL; League Avg: 43%.
The Cardinals threw the ball 60% of the time (649 Pass Attempts/1,074 plays) last season — 2nd-highest in NFL; League Avg: 52%.
The Cardinals targeted WRs 42% of the time (275 Pass Attempts/649 plays) last season — T-2nd-lowest in NFL; League Avg: 55%.
The Cardinals threw the ball 58% of the time (481 Pass Attempts/822 plays) on Early Downs last season — highest in NFL; League Avg: 49%.
Los Angeles Chargers Offense: Important Stats
The Chargers targeted RBs 12% of the time (70 Pass Attempts/569 plays) last season — 3rd-lowest in NFL; League Avg: 17%.
The Chargers allowed opponents to pressure their QB on 35% of pass attempts last season — worst in NFL; League Avg: 25%.
The Chargers converted late downs on 38 of 333 plays (11%) with 4-6 yards to go last season — 3rd-best in NFL; League Avg: 10%.
The Chargers targeted TEs 17% of the time (99 Pass Attempts/569 plays) last season — 3rd-lowest in NFL; League Avg: 23%.
Arizona Cardinals Defense: Important Stats
The Cardinals defense allowed a third down conversion rate of 11% on third and 10+ yards to go last season — 2nd-best in NFL; League Avg: 20%.
The Cardinals defense forced three and outs on 14% of opponent drives last season — worst in NFL; League Avg: 20%.
Cardinals were flagged 8 times for 10+ yards on defense last season — T-fewest in NFL.
The Cardinals defense allowed a passer rating of 72.1 when they pressured the QB (79 Pass Attempts) last season — 5th-worst in NFL; League Avg: 54.5.
Los Angeles Chargers Defense: Important Stats
The Chargers defense allowed -0.39 epa per play on contested throws last season — 2nd-best in NFL; League Avg: -0.11.
The Chargers defense did not allow a third down conversion with a heavy rush last season — best in NFL; League Avg: 40%.
The Chargers defense allowed 300.3 yards from scrimmage per game last season — 2nd-best in NFL; League Avg: 342.0.
The Chargers defense allowed a late down conversion rate of 15% in short yardage situations last season — T-4th-best in NFL; League Avg: 18%.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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