Cardinals vs Colts Prediction, Odds & Best Prop Bets – NFL, Week 6

BetMGM Betting Oct 08, 2025, 10:10 PM

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A general overall interior view of Lucas Oil Stadium as Chicago Bears take on the Indianapolis Colts during an NFL football game, Sunday, Sept. 22, 2024, in Indianapolis. The Colts defeated the Bears 21-16. (AP Photo/Zach Bolinger)

(AP Photo/Zach Bolinger)

The Colts are -7 point favorites vs the Cardinals
Total (Over/Under): 47 points
Watch this game on FOX

The Arizona Cardinals (2-3-0) visit Lucas Oil Stadium to take on the Indianapolis Colts (4-1-0) on Oct. 12. Kickoff is scheduled for 1:00pm EDT in Indianapolis, IN.

The Colts are betting favorites in this matchup, with the spread sitting at -7 (-110).

The Cardinals vs. Colts Over/Under is 47 total points for the game.

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Cardinals vs. Colts Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Cardinals	+7 -110	47 -105	280
Colts	-7 -110	47 -115	-350

Cardinals vs. Colts Prediction

The winning team model predicts the Colts will win this game with 69.4% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Cardinals vs Colts Spread Prediction

Based on recent against-the-spread trends, the model predicts the Colts will cover the spread with 52.1% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Cardinals players this game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today

Chad Ryland has hit the Field Goals Over in 12 of his last 17 games (+6.90 Units / 37% ROI)
Kyler Murray has hit the Completions Over in 12 of his last 17 games (+6.40 Units / 33% ROI)
Michael Wilson has hit the Receptions Under in 11 of his last 16 games (+6.05 Units / 32% ROI)
Kyler Murray has hit the Pass Attempts Over in 7 of his last 8 away games (+5.85 Units / 63% ROI)
Michael Wilson has hit the Receiving Yards Under in 11 of his last 16 games (+5.30 Units / 29% ROI)

And here are some top NFL player prop bets for Colts players for this matchup, looking at profitable historical betting trends:

Best Colts Player Prop Best Bets Today

Daniel Jones has hit the TD Passes Under in 8 of his last 10 games (+4.45 Units / 22% ROI)
Daniel Jones has hit the Interceptions Under in 5 of his last 6 games at home (+3.95 Units / 54% ROI)
Alec Pierce has hit the Receiving Yards Over in 5 of his last 6 games at home (+3.85 Units / 55% ROI)
Daniel Jones has hit the Rushing Yards Under in 7 of his last 10 games (+3.55 Units / 31% ROI)
Adonai Mitchell has hit the Receptions Under in 7 of his last 11 games (+2.85 Units / 19% ROI)

Receiving Props: Total Receiving Yards for Colts vs Cardinals

Player Name	Over	Under
Jonathan Taylor (IND)	16.5 -118	16.5 -110
Michael Pittman Jr. (IND)	53.5 -115	53.5 -115
Josh Downs (IND)	38.5 -118	38.5 -110
Tyler Warren (IND)	50.5 -115	50.5 -115

Rushing Props: Total Rushing Yards for Colts vs Cardinals

Player Name	Over	Under
Jonathan Taylor (IND)	89.5 -118	89.5 -110
Daniel Jones (IND)	17.5 -110	17.5 -120

Cardinals Best Bets:

The Arizona Cardinals have hit the 3Q Moneyline in 10 of their last 17 games (+5.60 Units / 24% ROI)
The Arizona Cardinals have hit the 3Q Game Total Under in 11 of their last 17 games (+4.45 Units / 24% ROI)
The Arizona Cardinals have covered the 3Q Spread in 11 of their last 17 games (+4.40 Units / 21% ROI)
The Arizona Cardinals have covered the 2H Spread in 10 of their last 16 games (+3.93 Units / 21% ROI)
The Arizona Cardinals have hit the 2Q Moneyline in 10 of their last 17 games (+3.65 Units / 15% ROI)

Colts Best Bets:

The Indianapolis Colts have hit the 1H Team Total Over in 14 of their last 20 games (+8.05 Units / 32% ROI)
The Indianapolis Colts have hit the 2Q Game Total Over in 12 of their last 17 games (+6.60 Units / 33% ROI)
The Indianapolis Colts have covered the 2Q Spread in 6 of their last 8 games at home (+3.70 Units / 37% ROI)
The Indianapolis Colts have hit the 2Q Moneyline in 4 of their last 8 games at home (+3.00 Units / 27% ROI)
The Indianapolis Colts have hit the Game Total Over in 11 of their last 20 games (+2.20 Units / 10% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 2-3 (-1.3 Units / -23.64% ROI).

Cardinals are 2-3 when betting on the Moneyline for -4.2 Units / -34.57% ROI
Cardinals are 2-3 when betting the Over for -1.3 Units / -23.64% ROI
Cardinals are 3-2 when betting the Under for +0.8 Units / ROI

Colts Against the Spread (ATS) Record

Against the spread this NFL season, the Colts are 4-1 (+2.9 Units / 52.73% ROI).

Colts are 4-1 when betting on the Moneyline for +3.05 Units / 33.33% ROI
Colts are 2-3 when betting the Over for -1.3 Units / -23.64% ROI
Colts are 3-2 when betting the Under for +0.8 Units / 14.55% ROI

Arizona Cardinals: Keys to the Game vs. the Indianapolis Colts

The Colts have scored on 65% of their drives (30/46) this season — best in NFL; League Avg: 40%.

The Colts have averaged 7.4 yards per play against tight coverage this season — best in NFL; League Avg: 3.1.

The Colts had a third down conversion rate of 80% in Week 5 — best in NFL; League Avg: 43%.

The Colts have scored on 64% of their drives (14/22) in the 2nd half this season — best in NFL; League Avg: 37%.

Indianapolis Colts: Keys to the Game vs. the Arizona Cardinals

The Colts defense has allowed a late down conversion rate of 5% when opponents had over 10 yards to go since the 2024 season — worst in NFL; League Avg: 3%.

The Colts defense has allowed a passer rating of just 36.0 on 3rd and short (34 Pass Attempts) since the 2024 season — best in NFL; League Avg: 90.6.

The Colts defense have missed 186 tackles since the 2024 season — most in NFL.

The Colts defense has allowed successful plays on 59% of rush attempts in the 4th quarter this season — 2nd-worst in NFL; League Avg: 41%.

Additional Matchup Notes for Arizona Cardinals vs. Indianapolis Colts