- The Panthers (1-2) are -2 point favorites vs the Cardinals (1-2)
- Total (Over/Under): 43.5 points
- Watch the game on FOX
The Arizona Cardinals (1-2) visit Bank of America Stadium to take on the Carolina Panthers (1-2) on Oct. 2. Kickoff is scheduled for 4:05pm EDT in Charlotte.
The Panthers are betting favorites in Week 4, with the spread sitting at -2 (-110).
The Cardinals vs. Panthers Over/Under is 43.5 total points for the game.
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Cardinals vs. Panthers Odds, Spread, Over/Under Week 4
| Spread | Total (O/U) | Moneyline | |
| Cardinals | +2 -110 | 43.5 -110 | +105 |
| Panthers | -2 -110 | 43.5 -110 | -125 |
Cardinals vs. Panthers Prediction for Week 4
Based on recent trends, the winning team model predicts the Cardinals will win this Week 4 game with 55.0% confidence.
Cardinals vs Panthers Spread Prediction for Week 4
Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread this Week 4 with 70.0% confidence.
Both predictions factor in up-to-date player injuries for both the Cardinals and Panthers, plus offensive & defensive matchups, recent games and key player performances this season.
Best Cardinals Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Cardinals players for Week 4, looking at profitable historical betting trends:
- Darrel Williams has hit the Receptions Over in 8 of his last 10 games (+7.10 Units / 61% ROI)
- Marquise Brown has hit the Receptions Over in 11 of his last 16 games (+7.00 Units / 41% ROI)
- Darrel Williams has hit the Rushing Yards Under in 8 of his last 10 games (+5.40 Units / 41% ROI)
- Rondale Moore has hit the Receiving Yards Under in 7 of his last 9 games (+4.35 Units / 37% ROI)
- Kyler Murray has hit the Rushing Yards Under in 9 of his last 13 games (+3.90 Units / 23% ROI)
Best Panthers Player Prop Best Bets Today
And here are some top NFL player prop bets for Panthers players for Week 4, looking at profitable historical betting trends:
- D.J. Moore has hit the Receiving Yards Under in 12 of his last 16 games (+7.15 Units / 36% ROI)
- Robby Anderson has hit the Receiving Yards Under in 12 of his last 16 games (+7.00 Units / 35% ROI)
- Laviska Shenault Jr. has hit the Receptions Over in his last 6 games at home (+6.50 Units / 92% ROI)
- Sam Darnold has hit the TD Passes Under in his last 6 games (+6.30 Units / 70% ROI)
- Sam Darnold has hit the Passing Yards Under in his last 6 games (+6.00 Units / 82% ROI)
Cardinals Betting Trends: ATS, Moneyline, Over/Under
- The Arizona Cardinals have hit the 3Q Game Total Over in 9 of their last 14 games (+6.95 Units / 45% ROI)
- The Arizona Cardinals have hit the 2H Game Total Over in 10 of their last 14 games (+6.55 Units / 42% ROI)
- The Arizona Cardinals have hit the 2Q Game Total Under in 9 of their last 14 games (+5.75 Units / 37% ROI)
- The Arizona Cardinals have covered the Spread in 7 of their last 9 away games (+4.90 Units / 50% ROI)
- The Arizona Cardinals have covered the 3Q Spread in 7 of their last 9 away games (+4.80 Units / 45% ROI)
Panthers Betting Trends: ATS, Moneyline, Over/Under
- The Carolina Panthers have hit the 1Q Moneyline in 7 of their last 16 games (+7.25 Units / 40% ROI)
- The Carolina Panthers have covered the 1Q Spread in 12 of their last 17 games (+6.55 Units / 31% ROI)
- The Carolina Panthers have scored first in 8 of their last 12 games (+5.70 Units / 42% ROI)
- The Carolina Panthers have hit the Team Total Under in 9 of their last 14 games (+4.55 Units / 29% ROI)
- The Carolina Panthers have hit the 1Q Game Total Under in 9 of their last 14 games (+4.30 Units / 26% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals have gone 1-2 (-1.25 Units / -37.31% ROI).
- Cardinals are 1-2 when betting on the Moneyline for +0 Units / 0% ROI
- Cardinals are 2-1 when betting the Over for +0.9 Units / 27.27% ROI
- Cardinals are 1-2 when betting the Under for -1.2 Units / ROI
Panthers Against the Spread (ATS) Record
Against the spread this NFL season, the Panthers have gone 1-2 (-1.2 Units / -36.36% ROI).
- Panthers are 1-2 when betting on the Moneyline for -1.3 Units / -38.24% ROI
- Panthers are 1-2 when betting the Over for -1.25 Units / -37.31% ROI
- Panthers are 2-1 when betting the Under for +0.9 Units / 27.69% ROI
Arizona Cardinals: Keys to the Game vs. the Carolina Panthers
The Cardinals are winless (0-4) when the opposing team rushes more than 30 times since the 2021 season — tied for worst in NFL; League Avg: .177.
The Cardinals are 2-3 (.400) when not forcing a turnover since the 2021 season — tied for 7th-best in NFL; League Avg: .264.
The Cardinals are 6-3 (.667) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — tied for 8th-best in NFL; League Avg: .538.
The Cardinals are 7-2 (.778) when making 7 or more explosive plays since the 2021 season — 2nd-best in NFL; League Avg: .565.
Carolina Panthers: Keys to the Game vs. the Arizona Cardinals
The Panthers are 3-14 (.176) when converting less than 50% of third down conversion opportunities since the 2021 season — 2nd-worst in NFL; League Avg: .422.
The Panthers are winless (0-9) when allowing more than 3 explosive runs since the 2021 season — tied for worst in NFL; League Avg: .407.
The Panthers are winless (0-7) since Week 11 — worst in NFL; League Avg: .500.
The Panthers are winless (0-5) when allowing more than 5 yards per rush since the 2021 season — worst in NFL; League Avg: .489.
Additional Matchup Notes for Arizona Cardinals vs. Carolina Panthers
The Panthers have run successful plays on just 9.1% of pass attempts when their QB was under pressure this season — tied for second-worst in NFL. The Cardinals have pressured opposing QBs on 33.0% of passing plays this season — fifth-best in NFL.
Panthers RBs have averaged 9.1 yards after the catch this season — fourth-best in NFL. The Cardinals have allowed 15.6 yards after catch per reception to RBs this season — worst in NFL.
The Panthers have allowed opponents to pressure their QB on 31.8% of pass attempts since the 2021 season — second-worst in NFL. The Cardinals have pressured opposing QBs on 27.6% of passing plays since the 2021 season — fifth-best in NFL.
The Cardinals have scored on 62.5% of their drives in the fourth quarter this season — best in NFL. The Panthers defense has allowed scores on 54.5% of opponent drives in the 4th quarter this season — tied for worst in NFL.
Cardinals WRs have 55 receptions in 3 games (18.3 per game) this season — best in NFL. The Panthers have allowed 15.7 receptions per game to WRs this season — fourth-worst in NFL.
The Cardinals went three and out on 33.3% of their drives last week — tied for fifth-worst in NFL. Panthers forced three and outs on 38.5% of opponent drives in Week 3 — fourth-best in NFL.
Arizona Cardinals Offense: Important Stats for Week 4
The Cardinals did not record a TD in 9 drives in Week 3 — tied for worst Drives Per TD rate in NFL; League Avg: 5.2.
The Cardinals have run successful plays on 58% of rush attempts this season — best in NFL; League Avg: 43%.
The Cardinals have faced a blitz 51 times this season — most in NFL.
The Cardinals have run no plays in their opponent’s territory in the 1st quarter this season — worst in NFL; League Avg: 41%.
Carolina Panthers Offense: Important Stats for Week 4
The Panthers ran successful plays on 40% of pass attempts last season — 2nd-worst in NFL; League Avg: 46%.
The Panthers ran successful plays on 28% of pass attempts in Week 3 — 2nd-worst in NFL; League Avg: 46%.
The Panthers have run successful plays on 32% of pass attempts this season — 2nd-worst in NFL; League Avg: 46%.
The Panthers ran successful plays on 37% of pass attempts in the 4th quarter last season — tied for worst in NFL; League Avg: 46%.
Arizona Cardinals Defense: Important Stats for Week 4
The Cardinals defense has averaged a sack every 52.5 pass attempts (105 Pass Attempts/2 Sacks) this season — 2nd-worst attempts per sack rate in NFL; League Avg: 15.7.
The Cardinals defense has forced 6 fumbles this season — most in NFL.
The Cardinals defense has allowed first downs on 47% of plays on plays when they have pressured the QB this season — worst in NFL; League Avg: 17%.
The Cardinals defense has no interceptions (103 pass attempts) this season — tied for worst in NFL; League Avg: 44.0.
Carolina Panthers Defense: Important Stats for Week 4
The Panthers defense sacked opposing QBs just once on 66 pass attempts in the red zone last season — worst attempts per sack rate in NFL; League Avg: 17.3.
The Panthers defense allowed successful plays on 32% of plays in the 1st quarter last season — best in NFL; League Avg: 43%.
The Panthers defense has allowed successful plays on 36% of plays in the 1st half since the 2021 season — 2nd-best in NFL; League Avg: 43%.
The Panthers defense has allowed successful plays on 31% of pass attempts in the 1st quarter since the 2021 season — best in NFL; League Avg: 46%.
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