Cardinals vs Rams Prediction, Odds & Best Prop Bets โ€“ NFL, Week 18

General interior view of SoFi Stadium, the home of Los Angeles Rams before an NFL football game between the Los Angeles Rams and the Seattle Seahawks, Sunday, Jan. 5, 2025, in Inglewood, Calif. (AP Photo/Kyusung Gong)
(AP Photo/Kyusung Gong)
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  • The Rams are -7.5 point favorites vs the Cardinals
  • Total (Over/Under): 46.5 points
  • Watch this game on FOX

The Arizona Cardinals (3-13-0) visit SoFi Stadium to take on the Los Angeles Rams (11-5-0) on Jan. 4. Kickoff is scheduled for 4:25pm EST in Inglewood, CA.

The Rams are betting favorites in this matchup, with the spread sitting at -7.5 (-102).

The Cardinals vs. Rams Over/Under is 46.5 total points for the game.

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Cardinals vs. Rams Odds, Spread, Over/Under

Cardinals vs. Rams Prediction

The winning team model predicts the Rams will win this game with 72.5% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.


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We’ve highlighted some favorite NFL player prop bets for Cardinals players this game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today

  • Jacoby Brissett has hit the TD Passes Over in 9 of his last 11 games (+9.35 Units / 75% ROI)
  • Jacoby Brissett has hit the Passing Yards Over in 9 of his last 11 games (+6.70 Units / 53% ROI)
  • Jacoby Brissett has hit the Carries Under in 6 of his last 7 games (+5.55 Units / 61% ROI)
  • Michael Carter has hit the Carries Under in his last 5 games (+5.00 Units / 88% ROI)
  • Elijah Higgins has hit the Receptions Over in 6 of his last 9 games (+4.90 Units / 50% ROI)

And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:

Best Rams Player Prop Best Bets Today

  • Blake Corum has hit the Receiving Yards Under in 9 of his last 10 games (+7.70 Units / 62% ROI)
  • Matthew Stafford has hit the TD Passes Over in 12 of his last 18 games (+7.15 Units / 34% ROI)
  • Colby Parkinson has hit the Receiving Yards Over in 8 of his last 10 games (+5.70 Units / 50% ROI)
  • Puka Nacua has hit the Rushing Yards Under in 10 of his last 13 games (+5.65 Units / 34% ROI)
  • Matthew Stafford has hit the Interceptions Under in 13 of his last 18 games (+5.65 Units / 24% ROI)
  • The Arizona Cardinals have hit the 4Q Game Total Over in 12 of their last 17 games (+6.50 Units / 34% ROI)
  • The Arizona Cardinals have hit the 1H Game Total Over in 13 of their last 20 games (+6.00 Units / 26% ROI)
  • The Arizona Cardinals have covered the 3Q Spread in 7 of their last 8 away games (+5.85 Units / 58% ROI)
  • The Arizona Cardinals have hit the 3Q Moneyline in 5 of their last 8 away games (+5.25 Units / 59% ROI)
  • The Arizona Cardinals have covered the 2H Spread in 6 of their last 7 away games (+4.75 Units / 56% ROI)
  • The Los Angeles Rams have covered the Spread in 17 of their last 22 games (+11.45 Units / 47% ROI)
  • The Los Angeles Rams have hit the Team Total Over in 17 of their last 22 games (+11.35 Units / 45% ROI)
  • The Los Angeles Rams have hit the 1H Team Total Over in 15 of their last 22 games (+8.00 Units / 31% ROI)
  • The Los Angeles Rams have hit the 1Q Game Total Over in 15 of their last 22 games (+7.20 Units / 27% ROI)
  • The Los Angeles Rams have hit the Moneyline in 9 of their last 11 games at home (+5.95 Units / 19% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this NFL season, the Cardinals are 6-10 (-5 Units / -28.41% ROI).

  • Cardinals are 3-13 when betting on the Moneyline for -12.7 Units / -54.86% ROI
  • Cardinals are 9-7 when betting the Over for +1.3 Units / 7.39% ROI
  • Cardinals are 7-9 when betting the Under for -2.9 Units / ROI

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams are 11-5 (+5.45 Units / 30.88% ROI).

  • Rams are 11-5 when betting on the Moneyline for -4 Units / -7.74% ROI
  • Rams are 9-7 when betting the Over for +1.3 Units / 7.39% ROI
  • Rams are 7-9 when betting the Under for -2.9 Units / -16.48% ROI

Arizona Cardinals: Keys to the Game vs. the Los Angeles Rams

The Cardinals defense missed 19 tackles in Week 17 — most in NFL.

23% of the plays run against the Cardinals have been in the red zone since Week 14 — worst in NFL; League Avg: 15%.

54% of the plays run against the Cardinals have been in their own territory this season — 2nd-worst in NFL; League Avg: 48%.

The Cardinals defense has allowed 6 TDs that were 20+ yards this season — 2nd-fewest in NFL.

Los Angeles Rams: Keys to the Game vs. the Arizona Cardinals

The Rams have thrown for 75 TDs this season — most in NFL.

The Rams have thrown 4.7 TD passes per game (75/16) this season — best in NFL; League Avg: 2.6.

The Rams have averaged 20.3 yards per play against a light rush this season — best in NFL; League Avg: 6.3.

The Rams have 140 receptions for 20+ yards this season — most in NFL.

Additional Matchup Notes for Arizona Cardinals vs. Los Angeles Rams

The Rams have thrown for 75 TDs this season — most in NFL.

The Rams have thrown 4.7 TD passes per game (75/16) this season — best in NFL; League Avg: 2.6.

The Rams have averaged 20.3 yards per play against a light rush this season — best in NFL; League Avg: 6.3.

The Rams have 140 receptions for 20+ yards this season — most in NFL.

The Cardinals defense missed 19 tackles in Week 17 — most in NFL.

23% of the plays run against the Cardinals have been in the red zone since Week 14 — worst in NFL; League Avg: 15%.

54% of the plays run against the Cardinals have been in their own territory this season — 2nd-worst in NFL; League Avg: 48%.

The Cardinals defense has allowed 6 TDs that were 20+ yards this season — 2nd-fewest in NFL.

Arizona Cardinals Offense: Important Stats

The Cardinals defense missed 19 tackles in Week 17 — most in NFL.

23% of the plays run against the Cardinals have been in the red zone since Week 14 — worst in NFL; League Avg: 15%.

54% of the plays run against the Cardinals have been in their own territory this season — 2nd-worst in NFL; League Avg: 48%.

The Cardinals defense has allowed 6 TDs that were 20+ yards this season — 2nd-fewest in NFL.

Los Angeles Rams Offense: Important Stats

The Rams have thrown for 75 TDs this season — most in NFL.

The Rams have thrown 4.7 TD passes per game (75/16) this season — best in NFL; League Avg: 2.6.

The Rams have averaged 20.3 yards per play against a light rush this season — best in NFL; League Avg: 6.3.

The Rams have 140 receptions for 20+ yards this season — most in NFL.

Arizona Cardinals Defense: Important Stats

The Cardinals defense missed 19 tackles in Week 17 — most in NFL.

23% of the plays run against the Cardinals have been in the red zone since Week 14 — worst in NFL; League Avg: 15%.

54% of the plays run against the Cardinals have been in their own territory this season — 2nd-worst in NFL; League Avg: 48%.

The Cardinals defense has allowed 6 TDs that were 20+ yards this season — 2nd-fewest in NFL.

Los Angeles Rams Defense: Important Stats

The Rams have thrown for 75 TDs this season — most in NFL.

The Rams have thrown 4.7 TD passes per game (75/16) this season — best in NFL; League Avg: 2.6.

The Rams have averaged 20.3 yards per play against a light rush this season — best in NFL; League Avg: 6.3.

The Rams have 140 receptions for 20+ yards this season — most in NFL.

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.