- The Chargers (5-5) are -4.5 point favorites vs the Cardinals (4-7)
- Total (Over/Under): 47.5 points
- Watch the game on CBS
The Los Angeles Chargers (5-5) visit State Farm Stadium to take on the Arizona Cardinals (4-7) on Nov. 27. Kickoff is scheduled for 4:05pm EST in Glendale.
The Chargers are betting favorites in Week 12, with the spread sitting at -3 (-110).
The Chargers vs. Cardinals Over/Under is 48 total points for the game.
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Chargers vs. Cardinals Odds, Spread, Over/Under Week 12
| Spread | Total (O/U) | Moneyline | |
| Chargers | -3 -110 | 48 -110 | -165 |
| Cardinals | +3 -110 | 48 -110 | +140 |
Chargers vs. Cardinals Prediction for Week 12
Based on recent trends, the winning team model predicts the Chargers will win this Week 12 game with 57.0% confidence.
Chargers vs Cardinals Spread Prediction for Week 12
Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread this Week 12 with 59.0% confidence.
Both predictions factor in up-to-date player injuries for both the Chargers and Cardinals, plus offensive & defensive matchups, recent games and key player performances this season.
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Best Chargers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Chargers players for Week 12, looking at profitable historical betting trends:
- Justin Herbert has hit the Interceptions Over in 11 of his last 16 games (+6.45 Units / 37% ROI)
- Austin Ekeler has hit the Receptions Over in 7 of his last 8 away games (+6.05 Units / 60% ROI)
- Keenan Allen has hit the Receptions Under in 7 of his last 8 games (+5.95 Units / 64% ROI)
- Justin Herbert has hit the Completions Over in 7 of his last 9 away games (+5.05 Units / 53% ROI)
- Mike Williams has hit the Receptions Over in 5 of his last 6 away games (+4.45 Units / 66% ROI)
Best Cardinals Player Prop Best Bets Today
And here are some top NFL player prop bets for Cardinals players for Week 12, looking at profitable historical betting trends:
- Marquise Brown has hit the Receptions Over in 9 of his last 13 games (+5.40 Units / 38% ROI)
- A.J. Green has hit the Receptions Under in 8 of his last 10 games (+5.25 Units / 37% ROI)
- Kyler Murray has hit the Passing Yards Under in 11 of his last 16 games (+4.85 Units / 24% ROI)
- A.J. Green has hit the Receiving Yards Under in 8 of his last 11 games (+4.25 Units / 30% ROI)
- James Conner has hit the Carries Under in his last 4 games at home (+4.00 Units / 74% ROI)
Chargers Best Bets for Week 12:
- The Los Angeles Chargers have covered the 2Q Spread in 13 of their last 15 games (+10.65 Units / 63% ROI)
- The Los Angeles Chargers have hit the 2Q Moneyline in 10 of their last 12 games (+8.90 Units / 50% ROI)
- The Los Angeles Chargers have hit the 3Q Game Total Under in 13 of their last 17 games (+8.30 Units / 43% ROI)
- The Los Angeles Chargers have hit the 2Q Game Total Over in 12 of their last 17 games (+7.40 Units / 37% ROI)
- The Los Angeles Chargers have hit the 2H Game Total Under in their last 6 games (+6.05 Units / 93% ROI)
Cardinals Best Bets for Week 12:
- The Arizona Cardinals have hit the 2H Game Total Over in 13 of their last 18 games (+7.35 Units / 37% ROI)
- The Arizona Cardinals have hit the Game Total Over in their last 5 games (+5.00 Units / 91% ROI)
- The Arizona Cardinals have hit the Team Total Under in 7 of their last 9 games at home (+4.65 Units / 46% ROI)
- The Arizona Cardinals have hit the 3Q Game Total Over in 5 of their last 9 games at home (+4.00 Units / 40% ROI)
- The Arizona Cardinals have covered the 2Q Spread in 4 of their last 6 games at home (+2.20 Units / 34% ROI)
Chargers Against the Spread (ATS) Record
Against the spread this NFL season, the Chargers have gone 7-3 (+3.7 Units / 33.64% ROI).
- Chargers are 5-5 when betting on the Moneyline for -2.95 Units / -17.61% ROI
- Chargers are 5-5 when betting the Over for -0.5 Units / -4.55% ROI
- Chargers are 5-5 when betting the Under for -0.5 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals have gone 5-6 (-1.65 Units / -13.58% ROI).
- Cardinals are 4-7 when betting on the Moneyline for -2.15 Units / -17.55% ROI
- Cardinals are 7-4 when betting the Over for +2.6 Units / 21.49% ROI
- Cardinals are 4-7 when betting the Under for -3.7 Units / -30.58% ROI
Los Angeles Chargers: Keys to the Game vs. the Arizona Cardinals
The Chargers are undefeated (3-0) when not throwing an interception this season — tied for best in NFL; League Avg: .634.
The Chargers are winless (0-4) when throwing 2 or more interceptions since the 2021 season — tied for worst in NFL; League Avg: .207.
The Chargers are 4-1 (.800) when allowing less than 3 explosive runs this season — 8th-best in NFL; League Avg: .574.
The Chargers are 4-1 (.800) when averaging more than 5 yards per rush since the 2021 season — 2nd-best in NFL; League Avg: .525.
Arizona Cardinals: Keys to the Game vs. the Los Angeles Chargers
The Cardinals are 1-4 (.200) at home this season — tied for 2nd-worst in NFL; League Avg: .540.
The Cardinals are winless (0-6) when scoring less than 22 points this season — tied for worst in NFL; League Avg: .269.
The Cardinals are winless (0-7) when allowing more than 3 explosive runs this season — tied for worst in NFL; League Avg: .400.
The Cardinals are winless (0-7) when the opposing team rushes more than 30 times since the 2021 season — tied for worst in NFL; League Avg: .210.
Additional Matchup Notes for Los Angeles Chargers vs. Arizona Cardinals
The Cardinals threw the ball 62.0% of the time last week — second-highest in NFL. The Chargers allowed 9.5 yards per dropback in Week 10 — third-worst in NFL.
The Cardinals have gone three and out on 5.6% of their drives in the fourth quarter this season — second-best in NFL. Chargers have forced three and outs on 3% of opponent drives in the 4th quarter this season — worst in NFL.
The Cardinals have thrown the ball 60.2% of the time since Week 7 — fourth-highest in NFL. The Chargers have allowed 7.8 yards per dropback since Week 7 — fifth-worst in NFL.
The Chargers had a third down conversion rate of 57.1% last week — third-best in NFL. The Cardinals defense allowed a third down conversion rate of 54.5% in Week 10 — fifth-worst in NFL.
The Chargers were successful on 58.5% of plays they have run last week — best in NFL. Cardinals allowed their opponents to be successful on 54.5% of plays in Week 10 — second-worst in NFL.
The Chargers ran successful plays on 60.0% of rush attempts last week — second-best in NFL. Cardinals allowed successful plays on 53.8% of rush attempts in Week 10 — fourth-worst in NFL.
Los Angeles Chargers Offense: Important Stats for Week 12
The Chargers averaged 121.6 yards from scrimmage per game (2,067 yards / 17 games) in the 4th quarter last season — best in NFL; League Avg: 94.8.
The Chargers ran successful plays on 73% of plays in the 1st quarter in Week 11 — best in NFL; League Avg: 41%.
The Chargers have run 4% of their plays in the red zone in the 1st quarter this season — 2nd-worst in NFL; League Avg: 12%.
The Chargers have not recorded a TD in 7 drives in the 3rd quarter since Week 8 — tied for worst Drives Per TD rate in NFL; League Avg: 4.9.
Arizona Cardinals Offense: Important Stats for Week 12
The Cardinals have run 749 plays this season — most in NFL.
The Cardinals have run successful plays on 64% of rush attempts in close and late situations this season — best in NFL; League Avg: 43%.
The Cardinals have run successful plays on 56% of rush attempts in the 4th quarter this season — best in NFL; League Avg: 42%.
The Cardinals have run 1,854 plays since the 2021 season — most in NFL.
Los Angeles Chargers Defense: Important Stats for Week 12
The Chargers defense has allowed an average of 2.2 yards after contact per carry (763 carries) since the 2021 season — worst in NFL; League Avg: 1.8.
20% of the plays run against the Chargers have been in the red zone in the 3rd quarter since the 2021 season — worst in NFL; League Avg: 12%.
The Chargers defense allowed a third down conversion rate of 49% last season — 2nd-worst in NFL; League Avg: 41%.
The Chargers defense has allowed an average of 2.3 yards after contact per carry (264 carries) this season — worst in NFL; League Avg: 1.7.
Arizona Cardinals Defense: Important Stats for Week 12
The Cardinals defense has allowed a passer rating of 100.7 when they have pressured the QB (77 Pass Attempts) this season — worst in NFL; League Avg: 54.0.
The Cardinals defense has allowed a passer rating of 88.7 when they have pressured the QB (169 Pass Attempts) since the 2021 season — 2nd-worst in NFL; League Avg: 56.1.
The Cardinals defense has allowed 25 first down receptions on passes when they have pressured the QB this season — most in NFL.
The Cardinals defense has allowed 29.1 Points per Game (320/11) this season — worst in NFL; League Avg: 21.8.
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