- The Bills are +2 point favorites vs the Chiefs
- Total (Over/Under): 52.5 points
- Watch this game on CBS
The Kansas City Chiefs (5-3-0) visit Highmark Stadium to take on the Buffalo Bills (5-2-0) on Nov. 2. Kickoff is scheduled for 4:25pm EDT in Orchard Park, NY.
The Bills are betting favorites in this matchup, with the spread sitting at +2 (-110).
The Chiefs vs. Bills Over/Under is 52.5 total points for the game.
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Chiefs vs. Bills Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Chiefs | -2 -110 | 52.5 -110 | -135 |
| Bills | +2 -110 | 52.5 -110 | 115 |
Chiefs vs. Bills Prediction
The winning team model predicts the Chiefs will win this game with 53.3% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Chiefs vs Bills Spread Prediction
Based on recent against-the-spread trends, the model predicts the Chiefs will cover the spread with 53.2% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Chiefs players this game, looking at profitable historical betting trends:
Best Chiefs Player Prop Bets Today
- Patrick Mahomes has hit the Interceptions Under in 15 of his last 19 games (+10.15 Units / 42% ROI)
- Xavier Worthy has hit the Receptions Over in 12 of his last 17 games (+6.80 Units / 32% ROI)
- Isiah Pacheco has hit the Carries Under in 11 of his last 15 games (+6.35 Units / 37% ROI)
- Kareem Hunt has hit the Receptions Under in 13 of his last 18 games (+6.25 Units / 24% ROI)
- Patrick Mahomes has hit the Pass Attempts Over in 13 of his last 19 games (+6.10 Units / 28% ROI)
And here are some top NFL player prop bets for Bills players for this matchup, looking at profitable historical betting trends:
Best Bills Player Prop Best Bets Today
- Ray Davis has hit the Rushing Yards Under in 12 of his last 14 games (+9.80 Units / 61% ROI)
- Elijah Moore has hit the Receptions Under in 10 of his last 12 games (+8.65 Units / 54% ROI)
- Keon Coleman has hit the Receptions Under in 11 of his last 14 games (+6.60 Units / 35% ROI)
- Josh Palmer has hit the Receiving Yards Over in 11 of his last 15 games (+6.30 Units / 36% ROI)
- Dalton Kincaid has hit the Longest Reception Over in his last 6 games (+6.00 Units / 87% ROI)
Chiefs Best Bets:
- The Kansas City Chiefs have hit the 1Q Moneyline in 13 of their last 20 games (+6.30 Units / 19% ROI)
- The Kansas City Chiefs have covered the 4Q Spread in 13 of their last 20 games (+5.35 Units / 24% ROI)
- The Kansas City Chiefs have hit the 2Q Moneyline in 11 of their last 20 games (+5.25 Units / 14% ROI)
- The Kansas City Chiefs have hit the 1H Moneyline in 14 of their last 22 games (+4.25 Units / 10% ROI)
- The Kansas City Chiefs have hit the 4Q Moneyline in 11 of their last 20 games (+3.65 Units / 11% ROI)
Bills Best Bets:
- The Buffalo Bills have hit the 2H Moneyline in 14 of their last 17 games (+12.02 Units / 34% ROI)
- The Buffalo Bills have covered the 2H Spread in 15 of their last 19 games (+10.37 Units / 46% ROI)
- The Buffalo Bills have hit the 3Q Moneyline in 12 of their last 19 games (+8.45 Units / 24% ROI)
- The Buffalo Bills have hit the Game Total Over in 14 of their last 22 games (+6.25 Units / 26% ROI)
- The Buffalo Bills have hit the Team Total Over in 14 of their last 22 games (+5.00 Units / 19% ROI)
Chiefs Against the Spread (ATS) Record
Against the spread this NFL season, the Chiefs are 4-3 (+0.7 Units / 9.09% ROI).
- Chiefs are 4-3 when betting on the Moneyline for -0.4 Units / -2.22% ROI
- Chiefs are 3-4 when betting the Over for -1.4 Units / -18.18% ROI
- Chiefs are 4-3 when betting the Under for +0.7 Units / ROI
Bills Against the Spread (ATS) Record
Against the spread this NFL season, the Bills are 3-4 (-1.4 Units / -18.3% ROI).
- Bills are 5-2 when betting on the Moneyline for -1.3 Units / -3.91% ROI
- Bills are 4-3 when betting the Over for +0.7 Units / 9.09% ROI
- Bills are 3-4 when betting the Under for -1.4 Units / -18.18% ROI
Kansas City Chiefs: Keys to the Game vs. the Buffalo Bills
The Bills defense has allowed an average of 3.2 yards after contact per carry (152 carries) to RBs this season — worst in NFL; League Avg: 2.1.
The Bills defense had 7 sacks in Week 8 — most in NFL.
The Bills defense has allowed first downs on 100% of rush attempts on 3rd and short this season — worst in NFL; League Avg: 68%.
The Bills defense has allowed just 180.3 receiving yards per game (1,262/7) this season — 2nd-best in NFL; League Avg: 229.6.
Buffalo Bills: Keys to the Game vs. the Kansas City Chiefs
The Chiefs have averaged -1.11 epa per play on contested throws this season — worst in NFL; League Avg: -0.04.
The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 46%.
The Chiefs have run successful plays on 63% of pass attempts since Week 5 — best in NFL; League Avg: 47%.
The Chiefs have averaged 9.3 yards per play when their QB has scrambled this season — 3rd-best in NFL; League Avg: 4.6.
Additional Matchup Notes for Kansas City Chiefs vs. Buffalo Bills
The Chiefs have averaged -1.11 epa per play on contested throws this season — worst in NFL; League Avg: -0.04.
The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 46%.
The Chiefs have run successful plays on 63% of pass attempts since Week 5 — best in NFL; League Avg: 47%.
The Chiefs have averaged 9.3 yards per play when their QB has scrambled this season — 3rd-best in NFL; League Avg: 4.6.
The Bills defense has allowed an average of 3.2 yards after contact per carry (152 carries) to RBs this season — worst in NFL; League Avg: 2.1.
The Bills defense had 7 sacks in Week 8 — most in NFL.
The Bills defense has allowed first downs on 100% of rush attempts on 3rd and short this season — worst in NFL; League Avg: 68%.
The Bills defense has allowed just 180.3 receiving yards per game (1,262/7) this season — 2nd-best in NFL; League Avg: 229.6.
Kansas City Chiefs Offense: Important Stats
The Bills defense has allowed an average of 3.2 yards after contact per carry (152 carries) to RBs this season — worst in NFL; League Avg: 2.1.
The Bills defense had 7 sacks in Week 8 — most in NFL.
The Bills defense has allowed first downs on 100% of rush attempts on 3rd and short this season — worst in NFL; League Avg: 68%.
The Bills defense has allowed just 180.3 receiving yards per game (1,262/7) this season — 2nd-best in NFL; League Avg: 229.6.
Buffalo Bills Offense: Important Stats
The Chiefs have averaged -1.11 epa per play on contested throws this season — worst in NFL; League Avg: -0.04.
The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 46%.
The Chiefs have run successful plays on 63% of pass attempts since Week 5 — best in NFL; League Avg: 47%.
The Chiefs have averaged 9.3 yards per play when their QB has scrambled this season — 3rd-best in NFL; League Avg: 4.6.
Kansas City Chiefs Defense: Important Stats
The Bills defense has allowed an average of 3.2 yards after contact per carry (152 carries) to RBs this season — worst in NFL; League Avg: 2.1.
The Bills defense had 7 sacks in Week 8 — most in NFL.
The Bills defense has allowed first downs on 100% of rush attempts on 3rd and short this season — worst in NFL; League Avg: 68%.
The Bills defense has allowed just 180.3 receiving yards per game (1,262/7) this season — 2nd-best in NFL; League Avg: 229.6.
Buffalo Bills Defense: Important Stats
The Chiefs have averaged -1.11 epa per play on contested throws this season — worst in NFL; League Avg: -0.04.
The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 46%.
The Chiefs have run successful plays on 63% of pass attempts since Week 5 — best in NFL; League Avg: 47%.
The Chiefs have averaged 9.3 yards per play when their QB has scrambled this season — 3rd-best in NFL; League Avg: 4.6.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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