- The Chargers are -1.5 point favorites vs the Colts
- Total (Over/Under): 48.5 points
- Watch this game on CBS
The Indianapolis Colts (5-1-0) visit SoFi Stadium to take on the Los Angeles Chargers (4-2-0) on Oct. 19. Kickoff is scheduled for 4:05pm EDT in Inglewood, CA.
The Chargers are betting favorites in this matchup, with the spread sitting at -1.5 (-110).
The Colts vs. Chargers Over/Under is 48.5 total points for the game.
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Colts vs. Chargers Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Colts | +1.5 -110 | 48.5 -110 | 110 |
| Chargers | -1.5 -110 | 48.5 -110 | -130 |
Colts vs. Chargers Prediction
The winning team model predicts the Chargers will win this game with 53.3% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Colts vs Chargers Spread Prediction
Based on recent against-the-spread trends, the model predicts the Chargers will cover the spread with 53.2% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Colts players this game, looking at profitable historical betting trends:
Best Colts Player Prop Bets Today
- Alec Pierce has hit the Receiving Yards Over in 10 of his last 14 games (+5.45 Units / 34% ROI)
- Daniel Jones has hit the Rushing Yards Under in 7 of his last 10 games (+3.55 Units / 31% ROI)
- Jonathan Taylor has hit the Receiving Yards Under in 10 of his last 16 games (+3.35 Units / 19% ROI)
- Jonathan Taylor has hit the Carries Over in 10 of his last 16 games (+3.25 Units / 18% ROI)
- Michael Pittman has hit the Receptions Over in 6 of his last 8 away games (+3.15 Units / 30% ROI)
And here are some top NFL player prop bets for Chargers players for this matchup, looking at profitable historical betting trends:
Best Chargers Player Prop Best Bets Today
- Keenan Allen has hit the Receiving Yards Over in 7 of his last 8 games at home (+5.85 Units / 62% ROI)
- Cameron Dicker has hit the Field Goals Over in 13 of his last 18 games (+5.30 Units / 19% ROI)
- Will Dissly has hit the Receiving Yards Over in his last 5 games at home (+5.00 Units / 85% ROI)
- Justin Herbert has hit the Rushing Yards Over in 7 of his last 9 games at home (+4.70 Units / 44% ROI)
- Keenan Allen has hit the Receptions Over in 6 of his last 8 games at home (+4.15 Units / 38% ROI)
Receiving Props: Total Receiving Yards for Chargers vs Colts
| Player Name | Over | Under |
|---|---|---|
| Jonathan Taylor (IND) | 17.5 -110 | 17.5 -118 |
| Tyler Warren (IND) | 54.5 -115 | 54.5 -115 |
| Michael Pittman Jr. (IND) | 49.5 -118 | 49.5 -110 |
Rushing Props: Total Rushing Yards for Chargers vs Colts
| Player Name | Over | Under |
|---|---|---|
| Daniel Jones (IND) | 17.5 -110 | 17.5 -118 |
| Jonathan Taylor (IND) | 88.5 -118 | 88.5 -115 |
| Justin Herbert (LAC) | 15.5 -118 | 15.5 -110 |
| Kimani Vidal (LAC) | 54.5 -115 | 54.5 -115 |
Colts Best Bets:
- The Indianapolis Colts have hit the 1H Team Total Over in 14 of their last 20 games (+8.05 Units / 32% ROI)
- The Indianapolis Colts have hit the 2Q Game Total Over in 12 of their last 17 games (+6.30 Units / 31% ROI)
- The Indianapolis Colts have covered the 1Q Spread in 8 of their last 10 away games (+5.85 Units / 47% ROI)
- The Indianapolis Colts have hit the Game Total Over in 12 of their last 20 games (+4.30 Units / 20% ROI)
- The Indianapolis Colts have hit the 2H Game Total Over in 5 of their last 6 away games (+3.88 Units / 59% ROI)
Chargers Best Bets:
- The Los Angeles Chargers have hit the 3Q Game Total Over in 14 of their last 19 games (+7.95 Units / 36% ROI)
- The Los Angeles Chargers have hit the 2H Game Total Over in their last 7 games at home (+7.00 Units / 88% ROI)
- The Los Angeles Chargers have covered the 1H Spread in 7 of their last 10 games at home (+4.60 Units / 39% ROI)
- The Los Angeles Chargers have hit the 1H Moneyline in 7 of their last 10 games at home (+4.55 Units / 27% ROI)
- The Los Angeles Chargers have hit the Game Total Over in 7 of their last 10 games at home (+3.70 Units / 34% ROI)
Colts Against the Spread (ATS) Record
Against the spread this NFL season, the Colts are 4-2 (+1.8 Units / 27.27% ROI).
- Colts are 5-1 when betting on the Moneyline for +4.05 Units / 30.57% ROI
- Colts are 3-3 when betting the Over for -0.3 Units / -4.55% ROI
- Colts are 3-3 when betting the Under for -0.3 Units / ROI
Chargers Against the Spread (ATS) Record
Against the spread this NFL season, the Chargers are 3-3 (-0.3 Units / -4.48% ROI).
- Chargers are 4-2 when betting on the Moneyline for +0.05 Units / 0.47% ROI
- Chargers are 2-4 when betting the Over for -2.4 Units / -36.36% ROI
- Chargers are 4-2 when betting the Under for +1.8 Units / 27.27% ROI
Indianapolis Colts: Keys to the Game vs. the Los Angeles Chargers
The Colts defense pressured opposing QBs 22 times in Week 6 — most in NFL.
The Colts defense missed 12 tackles in Week 6 — 2nd-most in NFL.
The Colts defense allowed a third down conversion rate of 64% in Week 6 — 2nd-worst in NFL; League Avg: 38%.
The Colts defense has allowed successful plays on 59% of rush attempts in the 4th quarter this season — 2nd-worst in NFL; League Avg: 41%.
Los Angeles Chargers: Keys to the Game vs. the Indianapolis Colts
The Chargers have thrown the ball 24% of the time (22 Pass Attempts/91 plays) on 3rd and short since the 2024 season — 2nd-lowest in NFL; League Avg: 44%.
The Chargers have faced a blitz 77 times this season — 2nd-most in NFL.
The Chargers have run successful plays on 58% of rush attempts in the 1st quarter this season — best in NFL; League Avg: 43%.
The Chargers had 6 rushes of 20+ yards in the last 4 weeks of the regular season — most in NFL.
Additional Matchup Notes for Indianapolis Colts vs. Los Angeles Chargers
The Chargers have thrown the ball 24% of the time (22 Pass Attempts/91 plays) on 3rd and short since the 2024 season — 2nd-lowest in NFL; League Avg: 44%.
The Chargers have faced a blitz 77 times this season — 2nd-most in NFL.
The Chargers have run successful plays on 58% of rush attempts in the 1st quarter this season — best in NFL; League Avg: 43%.
The Chargers had 6 rushes of 20+ yards in the last 4 weeks of the regular season — most in NFL.
The Colts defense pressured opposing QBs 22 times in Week 6 — most in NFL.
The Colts defense missed 12 tackles in Week 6 — 2nd-most in NFL.
The Colts defense allowed a third down conversion rate of 64% in Week 6 — 2nd-worst in NFL; League Avg: 38%.
The Colts defense has allowed successful plays on 59% of rush attempts in the 4th quarter this season — 2nd-worst in NFL; League Avg: 41%.
Indianapolis Colts Offense: Important Stats
The Colts defense pressured opposing QBs 22 times in Week 6 — most in NFL.
The Colts defense missed 12 tackles in Week 6 — 2nd-most in NFL.
The Colts defense allowed a third down conversion rate of 64% in Week 6 — 2nd-worst in NFL; League Avg: 38%.
The Colts defense has allowed successful plays on 59% of rush attempts in the 4th quarter this season — 2nd-worst in NFL; League Avg: 41%.
Los Angeles Chargers Offense: Important Stats
The Chargers have thrown the ball 24% of the time (22 Pass Attempts/91 plays) on 3rd and short since the 2024 season — 2nd-lowest in NFL; League Avg: 44%.
The Chargers have faced a blitz 77 times this season — 2nd-most in NFL.
The Chargers have run successful plays on 58% of rush attempts in the 1st quarter this season — best in NFL; League Avg: 43%.
The Chargers had 6 rushes of 20+ yards in the last 4 weeks of the regular season — most in NFL.
Indianapolis Colts Defense: Important Stats
The Colts defense pressured opposing QBs 22 times in Week 6 — most in NFL.
The Colts defense missed 12 tackles in Week 6 — 2nd-most in NFL.
The Colts defense allowed a third down conversion rate of 64% in Week 6 — 2nd-worst in NFL; League Avg: 38%.
The Colts defense has allowed successful plays on 59% of rush attempts in the 4th quarter this season — 2nd-worst in NFL; League Avg: 41%.
Los Angeles Chargers Defense: Important Stats
The Chargers have thrown the ball 24% of the time (22 Pass Attempts/91 plays) on 3rd and short since the 2024 season — 2nd-lowest in NFL; League Avg: 44%.
The Chargers have faced a blitz 77 times this season — 2nd-most in NFL.
The Chargers have run successful plays on 58% of rush attempts in the 1st quarter this season — best in NFL; League Avg: 43%.
The Chargers had 6 rushes of 20+ yards in the last 4 weeks of the regular season — most in NFL.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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