Giants vs Rams Prediction, Odds & Best Prop Bets – NFL, Week 2

• The Rams are -8.5 point favorites vs the Giants
• Total (Over/Under): 49 points
• Watch this game on ESPN | ABC

The New York Giants (1-0-0) visit SoFi Stadium to take on the Los Angeles Rams (0-1-0) on Sep. 21. Kickoff is scheduled for 8:15 pm in Inglewood, CA.

The Rams are betting favorites in this matchup, with the spread sitting at -8.5 (+110).

The Giants vs. Rams Over/Under is 49 total points for the game.

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Giants vs. Rams Odds, Spread, Over/Under

Giants vs. Rams Prediction

The winning team model predicts the Rams will win this game with 65.4% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Giants vs Rams Spread Prediction

Based on recent against-the-spread trends, the model predicts the Rams will cover the spread with 50.2% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Giants players this game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today

• Jaxson Dart has hit the Longest Rush Over in 10 of his last 13 games (+6.55 Units / 43% ROI)
• Theo Johnson has hit the Receptions Under in 11 of his last 14 games (+6.15 Units / 34% ROI)
• Jaxson Dart has hit the TD Passes Over in 9 of his last 13 games (+5.90 Units / 31% ROI)
• Devin Singletary has hit the Rushing Yards Over in 9 of his last 12 games (+5.55 Units / 40% ROI)
• Tyrone Tracy Jr. has hit the Rushing Yards Over in 10 of his last 14 games (+5.42 Units / 33% ROI)

And here are some top NFL player prop bets for Rams players for this matchup, looking at profitable historical betting trends:

Best Rams Player Prop Best Bets Today

• Kyren Williams has hit the Carries Under in 13 of his last 18 games (+7.60 Units / 37% ROI)
• Puka Nacua has hit the Rushing Yards Under in 11 of his last 14 games (+7.45 Units / 44% ROI)
• Davante Adams has hit the Receptions Under in 12 of his last 16 games (+7.45 Units / 37% ROI)
• Blake Corum has hit the Receiving Yards Under in 10 of his last 12 games (+7.00 Units / 45% ROI)
• Matthew Stafford has hit the TD Passes Over in 12 of his last 19 games (+6.05 Units / 27% ROI)

Anytime Touchdown Scorer Bet for Rams vs Giants

Giants Best Bets:

• The New York Giants have hit the 1H Moneyline in 11 of their last 19 games (+9.90 Units / 46% ROI)
• The New York Giants have covered the 3Q Spread in 13 of their last 16 games (+9.15 Units / 45% ROI)
• The New York Giants have hit the 1H Team Total Over in 13 of their last 17 games (+8.65 Units / 44% ROI)
• The New York Giants have hit the 3Q Game Total Under in 12 of their last 16 games (+7.60 Units / 41% ROI)
• The New York Giants have hit the 1Q Moneyline in 10 of their last 18 games (+7.05 Units / 35% ROI)

Rams Best Bets:

• The Los Angeles Rams have hit the Team Total Over in 15 of their last 21 games (+8.00 Units / 33% ROI)
• The Los Angeles Rams have hit the 2Q Game Total Over in 7 of their last 8 games at home (+5.90 Units / 63% ROI)
• The Los Angeles Rams have hit the 1H Team Total Over in 13 of their last 20 games (+4.55 Units / 19% ROI)
• The Los Angeles Rams have hit the 1H Moneyline in 14 of their last 22 games (+4.45 Units / 9% ROI)
• The Los Angeles Rams have covered the Spread in 13 of their last 22 games (+3.05 Units / 13% ROI)

Giants Against the Spread (ATS) Record

Against the spread this NFL season, the Giants are 1-0 (+1 Units / 90.91% ROI).

• Giants are 1-0 when betting on the Moneyline for +1.5 Units / 150% ROI
• Giants are 1-0 when betting the Over for +1 Units / 90.91% ROI
• GiantsGiantsGiants are 0-1 when betting the Under for -1.1 Units / -100% ROI

Rams Against the Spread (ATS) Record

Against the spread this NFL season, the Rams are 0-1 (-1.1 Units / -100% ROI).

• Rams are 0-1 when betting on the Moneyline for -1.95 Units / -100% ROI
• Rams are 0-1 when betting the Over for -1.1 Units / -100% ROI
• Rams are 1-0 when betting the Under for +1 Units / 90.91% ROI

New York Giants: Keys to the Game vs. the Los Angeles Rams

The Giants are winless (0-8) when throwing at least 1 interception since the 2025 season — T-worst in NFL; League Avg: .338.

The Giants are 2-10 (.167) when having a turnover margin within one of the opposing team since the 2025 season — worst in NFL; League Avg: .497.

The Giants are winless (0-8) whe trailing at the end of the first half since the 2025 season — T-worst in NFL; League Avg: .229.

The Giants are 1-8 (.111) on the road since the 2025 season — worst in NFL; League Avg: .454.

Los Angeles Rams: Keys to the Game vs. the New York Giants

The Rams were 6-3 (.667) when rushing less than 25 times last season — T-2nd-best in NFL; League Avg: .280.

The Rams are winless (0-4) when trailing at the end of the third quarter since the 2025 season — T-worst in NFL; League Avg: .155.

The Rams are 7-1 (.875) at home since the 2025 season — 3rd-best in NFL; League Avg: .543.

The Rams were 5-1 (.833) when having a turnover margin within one of the opposing team last season — T-3rd-best in NFL; League Avg: .497.

Additional Matchup Notes for New York Giants vs. Los Angeles Rams

The Rams have been successful on 50.5% of rush attempts since the 2025 season — best in NFL. The Giants have allowed a success rate of 49.3% on rush attempts since the 2025 season — 2nd-worst in NFL.

The Rams have averaged 0.23 epa per play on play action passes since the 2025 season — 5th-best in NFL. The Giants have allowed 0.21 epa per play on play action passes since the 2025 season — 3rd-worst in NFL.

The Rams were successful on 53.6% of rush attempts last week — 4th-best in NFL. The Giants allowed a success rate of 61.1% on rush attempts last week — worst in NFL.

The Giants were successful on 58.8% of rush attempts last week — 2nd-best in NFL. The Rams allowed a success rate of 53.3% on rush attempts last week — 5th-worst in NFL.

The Giants had a third down conversion rate of 81.8% last week — best in NFL. The Rams defense allowed a third down conversion rate of 58.3% last week — 4th-worst in NFL.

The Giants were successful on 60.0% of plays they ran last week — 2nd-best in NFL. The Rams allowed a success rate of 54.7% last week — 3rd-worst in NFL.

New York Giants Offense: Important Stats

The Giants have turned the ball over on downs 10 times in the red zone since the 2025 season — most in NFL.

The Giants ran successful plays on 78% of rush attempts in the 1st quarter in Week 1 — best in NFL; League Avg: 41%.

The Giants ran successful plays on 59% of rush attempts in Week 1 — 2nd-best in NFL; League Avg: 45%.

The Giants ran successful plays on 60% of plays in Week 1 — 2nd-best in NFL; League Avg: 44%.

Los Angeles Rams Offense: Important Stats

The Rams have thrown for 46 TDs since the 2025 season — most in NFL.

The Rams threw 2.7 TD passes per game (46/17) last season — best in NFL; League Avg: 1.5.

The Rams have thrown 2.6 TD passes per game (46/18) since the 2025 season — best in NFL; League Avg: 1.5.

The Rams threw for 46 TDs last season — most in NFL.

New York Giants Defense: Important Stats

The Giants defense has allowed successful plays on 55% of rush attempts in the 4th quarter since the 2025 season — worst in NFL; League Avg: 41%.

The Giants defense allowed successful plays on 55% of rush attempts in the 4th quarter last season — worst in NFL; League Avg: 41%.

The Giants defense has not allowed a TD pass when the opposing QB has scrambled since the 2025 season — T-fewest in NFL.

The Giants defense has allowed rushes of 10+ yards on 76 of 460 carries (17%) since the 2025 season — worst in NFL; League Avg: 11%.

Los Angeles Rams Defense: Important Stats

The Rams defense has allowed successful plays on 27% of rush attempts against play action passes since the 2025 season — best in NFL; League Avg: 53%.

The Rams defense allowed 0.78 epa per play with a stacked front last season — worst in NFL; League Avg: 0.07.

The Rams defense has allowed 6 rushing TDs on 63 carries (10.5 Carries Per TD) in the red zone since the 2025 season — best Carries Per TD rate in NFL; League Avg: 5.6.

The Rams defense allowed 6 rushing TDs on 61 carries (10.2 Carries Per TD) in the red zone last season — best Carries Per TD rate in NFL; League Avg: 5.6.

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More NFL Betting Predictions:

• Anytime & First Touchdown Scorer Predictions
• Receiving Yards Prop Predictions
• Rushing Yards Prop Predictions
• Passing Yards Prop Predictions
• Receptions Made Prop Predictions
• Rushing Attempts Prop Predictions
• Passing Touchdowns Prop Predictions
• QB Interception Prop Predictions
• Field Goals Made Prop Predictions
• NFL Betting Previews: Every Game

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