Lions vs Chiefs Prediction, Odds & Best Prop Bets – NFL, Week 6

Fans fly their Kansas City Chiefs flags outside GEHA Field at Arrowhead Stadium before a game against the Denver Broncos, Sunday, Nov. 10, 2024 in Kansas City, Mo. The Chiefs defeated the Broncos, 16-14. (AP Photo/Reed Hoffmann)
(AP Photo/Reed Hoffmann)
  • The Chiefs are -2.5 point favorites vs the Lions
  • Total (Over/Under): 53 points
  • Watch this game on NBC | PEAC | NBCU

The Detroit Lions (4-1-0) visit GEHA Field at Arrowhead Stadium to take on the Kansas City Chiefs (2-3-0) on Oct. 12. Kickoff is scheduled for 8:20pm EDT in Kansas City, MO.

The Chiefs are betting favorites in this matchup, with the spread sitting at -2.5 (-110).

The Lions vs. Chiefs Over/Under is 53 total points for the game.

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Lions vs. Chiefs Odds, Spread, Over/Under

SpreadTotal (O/U)Moneyline
Lions+2.5 -11053 -110115
Chiefs -2.5 -11053 -110-135

Lions vs. Chiefs Prediction

The winning team model predicts the will win this game with confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Lions vs Chiefs Spread Prediction

Based on recent against-the-spread trends, the model predicts the will cover the spread with confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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We’ve highlighted some favorite NFL player prop bets for Lions players this game, looking at profitable historical betting trends:

Best Lions Player Prop Bets Today

  • Jared Goff has hit the TD Passes Over in 13 of his last 19 games (+6.10 Units / 24% ROI)
  • Jahmyr Gibbs has hit the Rushing Yards Over in 13 of his last 19 games (+6.00 Units / 27% ROI)
  • Jahmyr Gibbs has hit the Receiving Yards Over in 8 of his last 10 away games (+5.70 Units / 49% ROI)
  • Jared Goff has hit the Interceptions Under in 8 of his last 10 away games (+5.30 Units / 40% ROI)
  • Jared Goff has hit the Passing Yards Over in 12 of his last 19 games (+3.85 Units / 17% ROI)

And here are some top NFL player prop bets for Chiefs players for this matchup, looking at profitable historical betting trends:

Best Chiefs Player Prop Best Bets Today

  • Xavier Worthy has hit the Receptions Over in 13 of his last 17 games (+9.40 Units / 46% ROI)
  • Isiah Pacheco has hit the Carries Under in 11 of his last 13 games (+8.85 Units / 61% ROI)
  • Patrick Mahomes has hit the Interceptions Under in 8 of his last 9 games at home (+6.85 Units / 61% ROI)
  • Patrick Mahomes has hit the TD Passes Under in 7 of his last 9 games at home (+6.15 Units / 62% ROI)
  • Patrick Mahomes has hit the Pass Attempts Over in 13 of his last 19 games (+6.10 Units / 28% ROI)

Receiving Props: Total Receiving Yards for Chiefs vs Lions

Player Name Over Under
Isiah Pacheco (KC) 8.5 -115 8.5 -115
Kareem Hunt (KC) 5.5 -118 5.5 -110
Hollywood Brown (KC) 40.5 -110 40.5 -118
JuJu Smith-Schuster (KC) 19.5 -110 19.5 -118
Noah Gray (KC) 10.5 -120 10.5 -110

Rushing Props: Total Rushing Yards for Chiefs vs Lions

Player Name Over Under
Patrick Mahomes (KC) 31.5 -110 31.5 -120
Isiah Pacheco (KC) 30.5 -118 30.5 -110
Jahmyr Gibbs (DET) 65.5 -118 65.5 -115
Kareem Hunt (KC) 27.5 -118 27.5 -110
Xavier Worthy (KC) 4.5 -120 4.5 -110
  • The Detroit Lions have covered the 3Q Spread in 15 of their last 19 games (+11.15 Units / 50% ROI)
  • The Detroit Lions have hit the Moneyline in 10 of their last 11 away games (+10.05 Units / 42% ROI)
  • The Detroit Lions have hit the 3Q Moneyline in 8 of their last 10 away games (+8.00 Units / 54% ROI)
  • The Detroit Lions have covered the Spread in 9 of their last 11 away games (+6.80 Units / 56% ROI)
  • The Detroit Lions have covered the 2Q Spread in 13 of their last 19 games (+5.95 Units / 27% ROI)
  • The Kansas City Chiefs have covered the 4Q Spread in 14 of their last 20 games (+7.55 Units / 33% ROI)
  • The Kansas City Chiefs have hit the 2Q Moneyline in 12 of their last 20 games (+6.25 Units / 17% ROI)
  • The Kansas City Chiefs have hit the Moneyline in 8 of their last 10 games at home (+6.20 Units / 22% ROI)
  • The Kansas City Chiefs have hit the 4Q Game Total Over in 13 of their last 20 games (+5.25 Units / 23% ROI)
  • The Kansas City Chiefs have covered the 2Q Spread in 7 of their last 9 games at home (+4.75 Units / 45% ROI)

Lions Against the Spread (ATS) Record

Against the spread this NFL season, the Lions are 4-1 (+2.9 Units / 52.73% ROI).

  • Lions are 4-1 when betting on the Moneyline for +4 Units / 26.23% ROI
  • Lions are 3-2 when betting the Over for +0.8 Units / 14.55% ROI
  • Lions are 2-3 when betting the Under for -1.3 Units / ROI

Chiefs Against the Spread (ATS) Record

Against the spread this NFL season, the Chiefs are 2-3 (-1.3 Units / -23.64% ROI).

  • Chiefs are 2-3 when betting on the Moneyline for -2.4 Units / -28.24% ROI
  • Chiefs are 3-2 when betting the Over for +0.8 Units / 14.55% ROI
  • Chiefs are 2-3 when betting the Under for -1.3 Units / -23.64% ROI

Detroit Lions: Keys to the Game vs. the Kansas City Chiefs

The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 45%.

The Chiefs ran successful plays on 73% of rush attempts in Week 5 — best in NFL; League Avg: 45%.

The Chiefs have averaged -0.76 epa per play on contested throws this season — worst in NFL; League Avg: -0.01.

The Chiefs ran successful plays on 76% of plays against a base front in Week 5 — best in NFL; League Avg: 48%.

Kansas City Chiefs: Keys to the Game vs. the Detroit Lions

The Chiefs defense has allowed successful plays on 74% of pass attempts against play action passes this season — worst in NFL; League Avg: 51%.

The Chiefs defense have allowed 11.5 yards per play against play action passes this season — worst in NFL; League Avg: 7.2.

The Chiefs defense has allowed 99.5 yards from scrimmage per game to RBs since the 2024 season — best in NFL; League Avg: 125.7.

The Chiefs defense has allowed successful plays on 44% of plays first read passes this season — 2nd-best in NFL; League Avg: 53%.

Additional Matchup Notes for Detroit Lions vs. Kansas City Chiefs

The Chiefs defense has allowed successful plays on 74% of pass attempts against play action passes this season — worst in NFL; League Avg: 51%.

The Chiefs defense have allowed 11.5 yards per play against play action passes this season — worst in NFL; League Avg: 7.2.

The Chiefs defense has allowed 99.5 yards from scrimmage per game to RBs since the 2024 season — best in NFL; League Avg: 125.7.

The Chiefs defense has allowed successful plays on 44% of plays first read passes this season — 2nd-best in NFL; League Avg: 53%.

The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 45%.

The Chiefs ran successful plays on 73% of rush attempts in Week 5 — best in NFL; League Avg: 45%.

The Chiefs have averaged -0.76 epa per play on contested throws this season — worst in NFL; League Avg: -0.01.

The Chiefs ran successful plays on 76% of plays against a base front in Week 5 — best in NFL; League Avg: 48%.

Detroit Lions Offense: Important Stats

The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 45%.

The Chiefs ran successful plays on 73% of rush attempts in Week 5 — best in NFL; League Avg: 45%.

The Chiefs have averaged -0.76 epa per play on contested throws this season — worst in NFL; League Avg: -0.01.

The Chiefs ran successful plays on 76% of plays against a base front in Week 5 — best in NFL; League Avg: 48%.

Kansas City Chiefs Offense: Important Stats

The Chiefs defense has allowed successful plays on 74% of pass attempts against play action passes this season — worst in NFL; League Avg: 51%.

The Chiefs defense have allowed 11.5 yards per play against play action passes this season — worst in NFL; League Avg: 7.2.

The Chiefs defense has allowed 99.5 yards from scrimmage per game to RBs since the 2024 season — best in NFL; League Avg: 125.7.

The Chiefs defense has allowed successful plays on 44% of plays first read passes this season — 2nd-best in NFL; League Avg: 53%.

Detroit Lions Defense: Important Stats

The Chiefs have run successful plays on 62% of plays in the 3rd quarter this season — best in NFL; League Avg: 45%.

The Chiefs ran successful plays on 73% of rush attempts in Week 5 — best in NFL; League Avg: 45%.

The Chiefs have averaged -0.76 epa per play on contested throws this season — worst in NFL; League Avg: -0.01.

The Chiefs ran successful plays on 76% of plays against a base front in Week 5 — best in NFL; League Avg: 48%.

Kansas City Chiefs Defense: Important Stats

The Chiefs defense has allowed successful plays on 74% of pass attempts against play action passes this season — worst in NFL; League Avg: 51%.

The Chiefs defense have allowed 11.5 yards per play against play action passes this season — worst in NFL; League Avg: 7.2.

The Chiefs defense has allowed 99.5 yards from scrimmage per game to RBs since the 2024 season — best in NFL; League Avg: 125.7.

The Chiefs defense has allowed successful plays on 44% of plays first read passes this season — 2nd-best in NFL; League Avg: 53%.

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.