Lions vs Panthers Prediction, Odds & Best Prop Bets – NFL, Week 16

min read
AP Photos
BetMGM Betting @BETMGM Dec 23, 2022, 10:30 AM
  • The Lions (7-7) are -3 point favorites vs the Panthers (5-9)
  • Total (Over/Under): 44 points
  • Watch the game on FOX

The Detroit Lions (7-7) visit Bank of America Stadium to take on the Carolina Panthers (5-9) on Dec. 24. Kickoff is scheduled for 1:00pm EST in Charlotte.

The Lions are betting favorites in Week 16, with the spread sitting at -2.5 (-115).

The Lions vs. Panthers Over/Under is 43.5 total points for the game.

Bet now on Panthers vs Lions & all NFL games with BetMGM

Lions vs. Panthers Odds, Spread, Over/Under Week 16

SpreadTotal (O/U)Moneyline
Lions-2.5 -11543.5 -110-145
Panthers +2.5 -10543.5 -110+120

Lions vs. Panthers Prediction for Week 16

Based on recent trends, the winning team model predicts the Lions will win this Week 16 game with 64.0% confidence.

Lions vs Panthers Spread Prediction for Week 16

Based on recent against-the-spread trends, the model predicts the Lions will cover the spread this Week 16 with 54.0% confidence.

Both predictions factor in up-to-date player injuries for both the Lions and Panthers, plus offensive & defensive matchups, recent games and key player performances this season.


Bet now on Panthers vs Lions and all NFL games with BetMGM


Best Lions Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for Lions players for Week 16, looking at profitable historical betting trends:

  • Jamaal Williams has hit the Receiving Yards Under in 10 of his last 12 games (+7.45 Units / 47% ROI)
  • Jared Goff has hit the Interceptions Under in his last 6 games (+6.20 Units / 84% ROI)
  • Kalif Raymond has hit the Receiving Yards Over in 7 of his last 9 games (+4.90 Units / 49% ROI)
  • Jamaal Williams has hit the Receptions Under in his last 4 games (+4.30 Units / 77% ROI)
  • Jared Goff has hit the Pass Attempts Over in his last 4 games (+4.00 Units / 90% ROI)

Best Panthers Player Prop Best Bets Today

And here are some top NFL player prop bets for Panthers players for Week 16, looking at profitable historical betting trends:

  • P.J. Walker has hit the Pass Attempts Under in 4 of his last 5 games (+2.85 Units / 42% ROI)
  • D’Onta Foreman has hit the Receiving Yards Under in 4 of his last 5 games (+2.75 Units / 43% ROI)
  • Ian Thomas has hit the Receiving Yards Under in 4 of his last 5 games at home (+2.75 Units / 41% ROI)
  • Terrace Marshall Jr. has hit the Receiving Yards Over in 6 of his last 9 games (+2.70 Units / 27% ROI)
  • P.J. Walker has hit the Completions Under in 4 of his last 5 games (+2.50 Units / 33% ROI)

First Touchdown Scorer Bet for Panthers vs Lions

Player Name 1st TD Odds
Jamaal Williams +650
D'Andre Swift +800
DJ Moore +800
Amon-Ra St. Brown +800
D'Onta Foreman +900

Anytime Touchdown Scorer Bet for Panthers vs Lions

Player Name Anytime TD Odds
Jamaal Williams +100
DJ Moore +120
D'Onta Foreman +125
Amon-Ra St. Brown +138
D'Andre Swift +140

Receiving Props: Total Receiving Yards for Panthers vs Lions

Player Name Over Under
Amon-Ra St. Brown 72.5 -115 72.5 -115
Terrace Marshall Jr. 35.5 -110 35.5 -120
D.J. Chark 33.5 -120 33.5 -110
D'Andre Swift 24.5 -120 24.5 -115
DJ Moore 55.5 -115 55.5 -115

Rushing Props: Total Rushing Yards for Panthers vs Lions

Player Name Over Under
D'Andre Swift 33.5 -120 33.5 -110
Jared Goff 1.5 -120 1.5 -110
Jamaal Williams 42.5 -115 42.5 -115
Sam Darnold 13.5 -120 13.5 -110
Chubba Hubbard 31.5 -110 31.5 -120
  • The Detroit Lions have covered the 1H Spread in their last 9 games (+9.05 Units / 92% ROI)
  • The Detroit Lions have scored first in 11 of their last 14 games (+8.60 Units / 55% ROI)
  • The Detroit Lions have hit the Team Total Over in 12 of their last 16 games (+7.30 Units / 38% ROI)
  • The Detroit Lions have hit the 2H Moneyline in 5 of their last 6 games (+7.00 Units / 109% ROI)
  • The Detroit Lions have covered the Spread in their last 7 games (+7.00 Units / 92% ROI)
  • The Carolina Panthers have hit the 1Q Game Total Under in 11 of their last 16 games (+10.95 Units / 53% ROI)
  • The Carolina Panthers have scored first in 11 of their last 17 games (+7.85 Units / 43% ROI)
  • The Carolina Panthers have hit the 1H Moneyline in 7 of their last 12 games (+6.05 Units / 48% ROI)
  • The Carolina Panthers have hit the 2H Game Total Over in 10 of their last 15 games (+5.75 Units / 35% ROI)
  • The Carolina Panthers have hit the 1Q Moneyline in 7 of their last 15 games (+5.60 Units / 35% ROI)

Lions Against the Spread (ATS) Record

Against the spread this NFL season, the Lions have gone 10-4 (+5.5 Units / 35.71% ROI).

  • Lions are 7-7 when betting on the Moneyline for +1 Units / 6.51% ROI
  • Lions are 9-5 when betting the Over for +3.5 Units / 22.73% ROI
  • Lions are 5-9 when betting the Under for -4.9 Units / ROI

Panthers Against the Spread (ATS) Record

Against the spread this NFL season, the Panthers have gone 7-7 (-0.75 Units / -4.89% ROI).

  • Panthers are 5-9 when betting on the Moneyline for +0.25 Units / 1.67% ROI
  • Panthers are 6-8 when betting the Over for -2.85 Units / -18.45% ROI
  • Panthers are 8-6 when betting the Under for +1.4 Units / 9.12% ROI

Detroit Lions: Keys to the Game vs. the Carolina Panthers

The Lions are winless (0-4) when losing at least one fumble this season — tied for worst in NFL; League Avg: .397.

The Lions are winless (0-4) when committing 2 or more turnovers this season — tied for worst in NFL; League Avg: .302.

The Lions are 2-8-1 (.182) when within 7 points entering the 4th quarter since the 2021 season — 3rd-worst in NFL; League Avg: .494.

The Lions are winless (0-15) whe trailing at the end of the frist half since the 2021 season — tied for worst in NFL; League Avg: .237.

Carolina Panthers: Keys to the Game vs. the Detroit Lions

The Panthers are winless (0-4) when within 3 points at the two minute warning since the 2021 season — tied for worst in NFL; League Avg: .491.

The Panthers are winless (0-6) when within 3 points at the two minute warning since the 2020 season — tied for worst in NFL; League Avg: .494.

The Panthers are winless (0-8) when rushing less than 25 times this season — tied for worst in NFL; League Avg: .318.

The Panthers are 2-17 (.105) when making less than 3 explosive runs in a game since the 2021 season — worst in NFL; League Avg: .443.

Additional Matchup Notes for Detroit Lions vs. Carolina Panthers

The Panthers have scored on 51.1% of their drives in the fourth quarter this season — best in NFL. The Lions defense has allowed scores on 40% of opponent drives in the 4th quarter this season — fifth-worst in NFL.

The Panthers have scored on 41.6% of their drives in the second half this season — fifth-best in NFL. The Lions defense has allowed scores on 42.9% of opponent drives in the second half this season — worst in NFL.

The Panthers have scored on 77.8% of their drives in the fourth quarter since Week 12 — best in NFL. The Lions defense has allowed scores on 45.5% of opponent drives in the 4th quarter since Week 12 — fifth-worst in NFL.

The Lions have run 17.9% offensive plays in the red zone since Week 12 — fifth-best in NFL. Panthers has allowed their opponent to run 18.1% of plays in the red zone since Week 12 — fifth-worst in NFL.

The Lions have a third down conversion rate of 48.2% in the second half this season — second-best in NFL. The Panthers defense has allowed a third down conversion rate of 44.1% in the second half this season — fourth-worst in NFL.

The Lions have a third down conversion rate of 50.0% in the second half since Week 12 — tied for fourth-best in NFL. The Panthers defense has allowed a third down conversion rate of 50.0% in the second half since Week 12 — fifth-worst in NFL.

Detroit Lions Offense: Important Stats for Week 16

The Lions ran successful plays on 28% of rush attempts in the red zone last season — worst in NFL; League Avg: 46%.

The Lions have run 21% of their plays in the red zone in the 1st quarter this season — best in NFL; League Avg: 12%.

The Lions did not go three and out on any of their drives in Week 15 — tied for best in NFL; League Avg: 21%.

The Lions had a third down conversion rate of 35% last season — worst in NFL; League Avg: 41%.

Carolina Panthers Offense: Important Stats for Week 16

The Panthers have run successful plays on 34% of pass attempts in the 3rd quarter since the 2021 season — worst in NFL; League Avg: 46%.

The Panthers ran successful plays on 12% of rush attempts in Week 15 — worst in NFL; League Avg: 48%.

The Panthers have run successful plays on 30% of pass attempts in the 3rd quarter this season — worst in NFL; League Avg: 47%.

The Panthers have run successful plays on 33% of pass attempts in the 1st quarter this season — worst in NFL; League Avg: 46%.

Detroit Lions Defense: Important Stats for Week 16

The Lions defense allowed 7 receptions for 20+ yards in Week 15 — most in NFL.

Offenses facing the Lions targeted RBs 11% of the time (118 Pass Attempts/1,033 plays) since the 2021 season — lowest in NFL; League Avg: 18%.

Offenses facing the Lions targeted RBs 10% of the time (51 Pass Attempts/489 plays) this season — lowest in NFL; League Avg: 18%.

The Lions defense have forced three and outs on 15% of opponent drives since the 2021 season — worst in NFL; League Avg: 21%.

Carolina Panthers Defense: Important Stats for Week 16

The Panthers defense has allowed scores on 13% of opponent drives in the 1st quarter this season — best in NFL; League Avg: 29%.

The Panthers defense allowed successful plays on 32% of plays in the 1st quarter last season — best in NFL; League Avg: 43%.

The Panthers defense has allowed scores on 15% of opponent drives in the 1st quarter since the 2021 season — best in NFL; League Avg: 28%.

The Panthers defense sacked opposing QBs just once on 66 pass attempts in the red zone last season — worst attempts per sack rate in NFL; League Avg: 17.3.

Looking to place a bet on this game with a First Bet Offer up to $1,000? Bet now on Panthers vs Lions and all NFL games with BetMGM

Bet on NFL Odds at BetMGM

At BetMGM, you can bet online with updated NFL betting odds. And with live sports betting, the best online sports betting and mobile sports betting (with the BetMGM Sportsbook app) experiences are at BetMGM.

About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.