NFL Odds Week 4: Biggest NFL Spreads This Week

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Green Bay Packers quarterback Aaron Rodgers (12) spins a football in his fingers before an NFL divisional playoff football game against the San Francisco 49ers, on Jan 22. 2022, in Green Bay, Wis.
(AP Photo/Jeffrey Phelps)
BetMGM Staff @BETMGM Sep 27, 2022, 12:40 PM
  • Below are the biggest NFL spreads of the week.
  • In Week 4, the Packers are favored by double-digits against the Patriots.

Following another exciting week, NFL odds are out for Week 4 and there’s the potential for a number of close games with short spreads.

NFL Odds Week 4: Biggest NFL Spreads This Week

RankMatchupSpread
1New England Patriots vs. Green Bay PackersPackers -10.5
T2Seattle Seahawks vs. Detroit LionsLions -6.5
T2Jacksonville Jaguars vs. Philadelphia EaglesEagles -6.5
4Los Angeles Chargers vs. Houston TexansChargers -6
T5Tennessee Titans vs. Indianapolis ColtsColts -3.5
T5Buffalo Bills vs. Baltimore RavensBills -3.5
T5New York Jets vs. Pittsburgh SteelersSteelers -3.5
T8Miami Dolphins vs. Cincinnati BengalsBengals -3
T8Chicago Bears vs. New York GiantsGiants -3
T8Washington Commanders vs. Dallas CowboysCowboys -3

1. New England Patriots vs. Green Bay Packers (-10.5)

After an impressive defensive victory over the Tampa Bay Buccaneers, the Green Bay Packers are well positioned ahead of this matchup with the New England Patriots. The latter appears to be without Mac Jones for the foreseeable future.

2. (Tie) Seattle Seahawks vs. Detroit Lions (-6.5)

Scoring has come easily for the Detroit Lions through three weeks, and they’ll enter this Week 4 matchup against the Seattle Seahawks as nearly a touchdown favorite.

2. (Tie) Jacksonville Jaguars vs. Philadelphia Eagles (-6.5)

It would be hard to say that the Philadelphia Eagles haven’t been the NFL’s most impressive team through three weeks, but the Jacksonville Jaguars could be in the running for that title, too. The fact that the Eagles are 6.5-point home favorites shows how strong they look on both sides of the ball.

4. Los Angeles Chargers (-6) vs. Houston Texans

The Los Angeles Chargers struggled to find consistency last week with a less than 100% Justin Herbert under center. In saying that, this offense projects to be very strong, especially in this matchup against the Houston Texans.

5. (Tie) Tennessee Titans vs. Indianapolis Colts (-3.5)

The Indianapolis Colts had one of the more impressive victories in Week 3 over the Kansas City Chiefs, and they’ll look to follow that performance up when they host the Tennessee Titans.

5. (Tie) Buffalo Bills (-3.5) vs. Baltimore Ravens

In what has the potential to be the game of the week, the Buffalo Bills will enter M&T Bank Stadium as 3.5-point favorites. Both the Bills and Ravens have Super Bowl or bust aspirations in 2022.

5. (Tie) New York Jets vs. Pittsburgh Steelers (-3.5)

The Pittsburgh Steelers and New York Jets will enter Week 4 with identical 1-2 records, but the Steelers are given the slight edge against the spread, likely as a result of home-field advantage.

8. (Tie) Miami Dolphins vs. Cincinnati Bengals (-3)

Thursday Night Football presents an exciting clash, the defending AFC champion Cincinnati Bengals playing host to the surging 3-0 Miami Dolphins. The Bengals are field-goal favorites in what should be a fun matchup on a short week.

8. (Tie) Chicago Bears vs. New York Giants (-3)

Neither the Chicago Bears nor New York Giants were expected to be competitive entering 2022, but both teams will enter this contest with records above .500. The phrase, “it’s still early” should certainly be applied here.

8. (Tie) Washington Commanders vs. Dallas Cowboys (-3)

The Washington Commanders got somewhat of a reality check in Week 3 against the Philadelphia Eagles and will head to Dallas looking to get back in the win column as underdogs.

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Our BetMGM authors are sports experts, with a wealth of knowledge of the sports betting industry at all levels. Their coverage includes sports news across players, teams and coaches, providing betting previews and predictions, fun facts and more.

Our BetMGM authors are sports experts, with a wealth of knowledge of the sports betting industry at all levels. Their coverage includes sports news across players, teams and coaches, providing betting previews and predictions, fun facts and more.