- The 49ers (1-2) are -1.5 point favorites vs the Rams (2-1)
- Total (Over/Under): 43 points
- Watch the game on ESPN
The Los Angeles Rams (2-1) visit Levi’s Stadium to take on the San Francisco 49ers (1-2) on Oct. 3. Kickoff is scheduled for 8:15pm EDT in Santa Clara.
The 49ers are betting favorites in Week 4, with the spread sitting at -1.5 (-110).
The Rams vs. 49ers Over/Under is 43 total points for the game.
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Rams vs. 49ers Odds, Spread, Over/Under Week 4
| Spread | Total (O/U) | Moneyline | |
| Rams | +1.5 -110 | 43 -110 | +105 |
| 49ers | -1.5 -110 | 43 -110 | -125 |
Rams vs. 49ers Prediction for Week 4
Based on recent trends, the winning team model predicts the 49ers will win this Week 4 game with 65.8% confidence.
Rams vs 49ers Spread Prediction for Week 4
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 4 with 62.0% confidence.
Both predictions factor in up-to-date player injuries for both the Rams and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.
Best Rams Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Rams players for Week 4, looking at profitable historical betting trends:
- Allen Robinson has hit the Receptions Under in 9 of his last 10 games (+7.45 Units / 48% ROI)
- Van Jefferson has hit the Receptions Under in 11 of his last 14 games (+7.10 Units / 33% ROI)
- Matthew Stafford has hit the Interceptions Over in 14 of his last 21 games (+6.85 Units / 28% ROI)
- Cooper Kupp has hit the Receiving Yards Over in 14 of his last 21 games (+5.80 Units / 23% ROI)
- Darrell Henderson has hit the Receiving Yards Under in 8 of his last 12 games (+2.90 Units / 19% ROI)
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for Week 4, looking at profitable historical betting trends:
- Jimmy Garoppolo has hit the Completions Under in 12 of his last 15 games (+8.50 Units / 44% ROI)
- Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+7.00 Units / 25% ROI)
- George Kittle has hit the Receptions Under in 11 of his last 15 games (+6.05 Units / 28% ROI)
- Jimmy Garoppolo has hit the Rushing Yards Under in 8 of his last 10 games (+5.25 Units / 42% ROI)
- Jimmy Garoppolo has hit the Interceptions Over in 10 of his last 15 games (+4.90 Units / 28% ROI)
Rams Betting Trends: ATS, Moneyline, Over/Under
- The Los Angeles Rams have hit the Moneyline in 11 of their last 13 games (+9.15 Units / 28% ROI)
- The Los Angeles Rams have hit the 1H Game Total Under in 10 of their last 11 games (+8.90 Units / 74% ROI)
- The Los Angeles Rams have hit the 1Q Game Total Under in 14 of their last 20 games (+7.45 Units / 34% ROI)
- The Los Angeles Rams have scored first in 9 of their last 11 games (+6.55 Units / 42% ROI)
- The Los Angeles Rams have hit the 3Q Game Total Over in 10 of their last 14 games (+6.55 Units / 40% ROI)
49ers Betting Trends: ATS, Moneyline, Over/Under
- The San Francisco 49ers have hit the 1Q Game Total Under in 10 of their last 11 games (+9.05 Units / 74% ROI)
- The San Francisco 49ers have hit the Game Total Under in 10 of their last 11 games (+8.90 Units / 74% ROI)
- The San Francisco 49ers have hit the 1H Game Total Under in 8 of their last 9 games (+8.00 Units / 80% ROI)
- The San Francisco 49ers have covered the Spread in 11 of their last 15 games (+6.75 Units / 41% ROI)
- The San Francisco 49ers have covered the 1H Spread in 11 of their last 15 games (+6.70 Units / 41% ROI)
Rams Against the Spread (ATS) Record
Against the spread this NFL season, the Rams have gone 1-2 (-1.2 Units / -36.92% ROI).
- Rams are 2-1 when betting on the Moneyline for +1 Units / 12.99% ROI
- Rams are 1-2 when betting the Over for -1.2 Units / -36.36% ROI
- Rams are 2-1 when betting the Under for +0.9 Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 1-2 (-1.2 Units / -36.36% ROI).
- 49ers are 1-2 when betting on the Moneyline for -2.85 Units / -37.25% ROI
- 49ers are 0-3 when betting the Over for -3.3 Units / -100% ROI
- 49ers are 3-0 when betting the Under for +3 Units / 90.91% ROI
Los Angeles Rams: Keys to the Game vs. the San Francisco 49ers
The Rams are undefeated (9-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — tied for best in NFL; League Avg: .538.
The Rams are winless (0-6) when allowing 27 or more points since the 2021 season — tied for worst in NFL; League Avg: .195.
The Rams are 6-1 (.857) when passing for more than 300 yards since the 2021 season — tied for best in NFL; League Avg: .560.
The Rams are 2-2 (.500) when not forcing a turnover since the 2021 season — 3rd-best in NFL; League Avg: .264.
San Francisco 49ers: Keys to the Game vs. the Los Angeles Rams
The 49ers were 4-2 (.667) vs top 10 pass offenses last season — tied for 5th-best in NFL; League Avg: .365.
The 49ers are 2-3 (.400) when the opposing team rushes more than 30 times since the 2021 season — 3rd-best in NFL; League Avg: .177.
The 49ers are undefeated (7-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — tied for best in NFL; League Avg: .538.
The 49ers are undefeated (5-0) vs bottom 10 run offenses since the 2021 season — tied for best in NFL; League Avg: .545.
Additional Matchup Notes for Los Angeles Rams vs. San Francisco 49ers
49ers TEs have just 28.7 receiving yards per game this season — tied for fourth-worst in NFL. The Rams have allowed an average ofjust 24.7 receiving yards per game to TEs this season — fourth-best in NFL.
The 49ers have allowed opponents to pressure their QB on 20.6% of pass attempts since the 2021 season — fifth-best in NFL. The Rams have pressured opposing QBs on just 22.2% of passing plays since the 2021 season — fourth-worst in NFL.
The 49ers have an average drive start position from the 23.6 yard line since the 2021 season — worst in NFL. The Rams have allowed an average drive start position from the 24.2 yard line since the 2021 season — second-best in NFL.
The Rams have thrown the ball 56.5% of the time in the red zone since the 2021 season — fourth-highest in NFL. The 49ers have allowed a completion rate of 65.5% when defending in the red zone since the 2021 season — worst in NFL.
The Rams have rushed for 219 yards this season — third-fewest in NFL. The 49ers have allowed 241 yards rushing this season — fourth-fewest in NFL.
The Rams have rushed for 1,921 yards since the 2021 season — fifth-fewest in NFL. The 49ers have allowed 2,014 yards rushing since the 2021 season — fifth-fewest in NFL.
Los Angeles Rams Offense: Important Stats for Week 4
The Rams have converted first downs on 8 of 9 plays (89%) on 3rd and short this season — best in NFL; League Avg: 54%.
The Rams have a third down conversion rate of 60% against the blitz since the 2021 season — 2nd-best in NFL; League Avg: 38%.
The Rams ran 27% of their plays in the red zone in the 4th quarter last season — 2nd-best in NFL; League Avg: 17%.
The Rams have targeted WRs 70% of the time (499 Pass Attempts/709 plays) since the 2021 season — highest in NFL; League Avg: 57%.
San Francisco 49ers Offense: Important Stats for Week 4
The 49ers started 8 drives inside their own 20 yard line in Week 3 — most in NFL.
The 49ers ran successful plays on 16% of rush attempts in Week 3 — worst in NFL; League Avg: 43%.
The 49ers ran 19% of their plays in their opponent’s territory in Week 3 — worst in NFL; League Avg: 44%.
The 49ers have run successful plays on 31% of plays in the 3rd quarter this season — 3rd-worst in NFL; League Avg: 45%.
Los Angeles Rams Defense: Important Stats for Week 4
The Rams’ opponents averaged 36.7 Passing Attempts per TD (624 Pass Attempts/17 Passing TDs) last season — 2nd-best Pass Attempts Per TD rate in NFL; League Avg: 22.3.
The Rams defense allowed successful plays on 28% of rush attempts in the 1st quarter last season — best in NFL; League Avg: 42%.
The Rams defense allowed 17 TD passes last season — 2nd-fewest in NFL.
The Rams defense allowed no passing TDs (58 pass attempts) in Week 3 — tied for best Pass Attempts Per TD rate in NFL; League Avg: 29.6.
San Francisco 49ers Defense: Important Stats for Week 4
The 49ers defense forced three and outs on 64% of opponent drives in Week 3 — best in NFL; League Avg: 21%.
The 49ers defense have forced three and outs on 44% of opponent drives this season — best in NFL; League Avg: 20%.
The 49ers defense allowed successful plays on 27% of pass attempts in Week 3 — best in NFL; League Avg: 46%.
The 49ers defense allowed successful plays on 10% of plays in the 1st quarter in Week 3 — best in NFL; League Avg: 45%.
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