Seahawks vs 49ers Prediction, Odds & Best Prop Bets – NFL, Week 18

BetMGM Betting Dec 31, 2025, 4:13 PM

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An exterior of Levi's Stadium is shown before an NFL preseason football game between the San Francisco 49ers and the Los Angeles Chargers in Santa Clara, Calif., Thursday, Aug. 29, 2019. (AP Photo/Tony Avelar)

(AP Photo/Tony Avelar)

The Favorite Team are Favorite Spread point favorites vs the Underdog Team
Total (Over/Under): 48.5 points
Watch this game on ABC | ESPN

The Seattle Seahawks (13-3-0) visit Levi’s Stadium to take on the San Francisco 49ers (12-4-0) on Jan. 3. Kickoff is scheduled for 8:00pm EST in Santa Clara, CA.

The are betting favorites in this matchup, with the spread sitting at ().

The Seahawks vs. 49ers Over/Under is 48.5 total points for the game.

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Seahawks vs. 49ers Odds, Spread, Over/Under

Seahawks vs. 49ers Prediction

The winning team model predicts the Seahawks will win this game with 52.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Seahawks vs 49ers Spread Prediction

Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread with 52.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Seahawks players this game, looking at profitable historical betting trends:

Best Seahawks Player Prop Bets Today

Elijah Arroyo has hit the Receptions Under in 9 of his last 10 games (+8.35 Units / 61% ROI)
Elijah Arroyo has hit the Receiving Yards Under in 8 of his last 10 games (+5.70 Units / 50% ROI)
Elijah Arroyo has hit the Longest Reception Under in 8 of his last 10 games (+5.70 Units / 49% ROI)
Jaxon Smith-Njigba has hit the Receptions Over in 12 of his last 17 games (+5.70 Units / 28% ROI)
Jason Myers has hit the Field Goals Over in 12 of his last 17 games (+5.45 Units / 23% ROI)

And here are some top NFL player prop bets for 49ers players for this matchup, looking at profitable historical betting trends:

Best 49ers Player Prop Best Bets Today

George Kittle has hit the Longest Reception Over in his last 6 games (+6.00 Units / 88% ROI)
Kyle Juszczyk has hit the Receiving Yards Over in 8 of his last 10 games (+5.70 Units / 49% ROI)
Kyle Juszczyk has hit the Receptions Over in 5 of his last 6 games (+5.65 Units / 71% ROI)
Christian McCaffrey has hit the Longest Rush Under in 11 of his last 16 games (+5.45 Units / 29% ROI)
Christian McCaffrey has hit the Carries Over in 9 of his last 12 games (+5.35 Units / 37% ROI)

First Touchdown Scorer Bet for 49ers vs Seahawks

Player Name	1st TD Odds
Sam Darnold (SEA)	+4000
Kenneth Walker III (Sea)	+800
Zach Charbonnet (Sea)	+725
Cam Akers (SEA)	+10000
Jaxon Smith-Njigba (SEA)	+625

Receiving Props: Total Receiving Yards for 49ers vs Seahawks

Player Name	Over	Under
Kenneth Walker III (SEA)	11.5 -110	11.5 -120
Zach Charbonnet (SEA)	10.5 -110	10.5 -118
AJ Barner (SEA)	35.5 -115	35.5 -115
Ricky Pearsall (SF)	44.5 -115	44.5 -115
Jauan Jennings (SF)	43.5 -110	43.5 -118

Rushing Props: Total Rushing Yards for 49ers vs Seahawks

Player Name	Over	Under
Christian McCaffrey (SF)	69.5 -115	69.5 -115
Sam Darnold (SEA)	5.5 -118	5.5 -110
Brock Purdy (SF)	14.5 -110	14.5 -118
Zach Charbonnet (SEA)	44.5 -115	44.5 -115
Kenneth Walker III (SEA)	48.5 -118	48.5 -110

Seahawks Best Bets:

The Seattle Seahawks have hit the Moneyline in 15 of their last 20 games (+10.75 Units / 20% ROI)
The Seattle Seahawks have hit the 3Q Moneyline in 7 of their last 9 away games (+7.45 Units / 46% ROI)
The Seattle Seahawks have hit the Team Total Over in 14 of their last 20 games (+7.05 Units / 30% ROI)
The Seattle Seahawks have covered the 3Q Spread in 11 of their last 17 games (+6.15 Units / 32% ROI)
The Seattle Seahawks have covered the Spread in 13 of their last 20 games (+5.40 Units / 25% ROI)

49ers Best Bets:

The San Francisco 49ers have hit the Moneyline in 14 of their last 20 games (+11.05 Units / 31% ROI)
The San Francisco 49ers have hit the 3Q Game Total Over in 14 of their last 17 games (+10.35 Units / 49% ROI)
The San Francisco 49ers have hit the 1H Game Total Over in 14 of their last 20 games (+9.35 Units / 40% ROI)
The San Francisco 49ers have hit the Game Total Over in 14 of their last 20 games (+8.50 Units / 39% ROI)
The San Francisco 49ers have covered the 1Q Spread in 14 of their last 20 games (+7.75 Units / 33% ROI)

Seahawks Against the Spread (ATS) Record

Against the spread this NFL season, the Seahawks are 11-5 (+5.5 Units / 31.34% ROI).

Seahawks are 13-3 when betting on the Moneyline for +9.75 Units / 20.81% ROI
Seahawks are 9-7 when betting the Over for +1.3 Units / 7.39% ROI
Seahawks are 7-9 when betting the Under for -2.9 Units / ROI

49ers Against the Spread (ATS) Record

Against the spread this NFL season, the 49ers are 10-5 (+4.5 Units / 25.57% ROI).

49ers are 12-4 when betting on the Moneyline for +9.95 Units / 30.95% ROI
49ers are 10-5 when betting the Over for +4.5 Units / 25.57% ROI
49ers are 5-10 when betting the Under for -6 Units / -34.09% ROI

Seattle Seahawks: Keys to the Game vs. the San Francisco 49ers

The Seahawks started 4 drives inside opposing territory in Week 17 — T-most in NFL.

The Seahawks have converted first downs on 29 of 68 plays (43%) when their QB has scrambled this season — best in NFL; League Avg: 21%.

The Seahawks have averaged 10.6 yards per play when their QB has scrambled this season — best in NFL; League Avg: 4.5.

The Seahawks had an average drive start position from the 47.3 yard line in Week 17 — best in NFL; League Avg: 28.6.

San Francisco 49ers: Keys to the Game vs. the Seattle Seahawks

The 49ers defense has allowed successful plays on 83% of rush attempts in the 4th quarter since Week 14 — worst in NFL; League Avg: 39%.

The 49ers defense have allowed 0.13 epa per play open coverage this season — 2nd-best in NFL; League Avg: 0.40.

The 49ers defense has allowed a passer rating of 117.9 on contested throws (122 Pass Attempts) this season — worst in NFL; League Avg: 71.8.

The 49ers defense have allowed 20.6 yards per play with a light rush this season — worst in NFL; League Avg: 6.3.

Additional Matchup Notes for Seattle Seahawks vs. San Francisco 49ers