- The Seahawks are -6 point favorites vs the Cardinals
- Total (Over/Under): 43.5 points
- Watch this game on FOX
The Seattle Seahawks (1-0-0) visit State Farm Stadium to take on the Arizona Cardinals (1-0-0) on Sep. 20. Kickoff is scheduled for 4:25 pm in Glendale, AZ.
The Seahawks are betting favorites in this matchup, with the spread sitting at -6 (+115).
The Seahawks vs. Cardinals Over/Under is 43.5 total points for the game.
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Seahawks vs. Cardinals Odds, Spread, Over/Under
| Spread | Total (O/U) | Moneyline | |
| Seahawks | -6 +115 | 43.5 -160 | -210 |
| Cardinals | +6 -155 | 43.5 +120 | +170 |
Seahawks vs. Cardinals Prediction
The winning team model predicts the Seahawks will win this game with 54.7% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.
Seahawks vs Cardinals Spread Prediction
Based on recent against-the-spread trends, the model predicts the Seahawks will cover the spread with 50.5% confidence.
This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.
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We’ve highlighted some favorite NFL player prop bets for Seahawks players this game, looking at profitable historical betting trends:
Best Seahawks Player Prop Bets Today
- Elijah Arroyo has hit the Receptions Under in 9 of his last 10 games (+8.35 Units / 61% ROI)
- Jason Myers has hit the Field Goals Over in 14 of his last 18 games (+8.10 Units / 30% ROI)
- Emanuel Wilson has hit the Longest Rush Under in 10 of his last 13 games (+6.60 Units / 44% ROI)
- Rashid Shaheed has hit the Longest Reception Under in 13 of his last 19 games (+6.30 Units / 29% ROI)
- Elijah Arroyo has hit the Receiving Yards Under in 8 of his last 10 games (+5.70 Units / 50% ROI)
And here are some top NFL player prop bets for Cardinals players for this matchup, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today
- Jacoby Brissett has hit the TD Passes Over in 10 of his last 13 games (+9.65 Units / 67% ROI)
- Jacoby Brissett has hit the Passing Yards Over in 11 of his last 13 games (+8.70 Units / 58% ROI)
- Elijah Higgins has hit the Receptions Over in 7 of his last 10 games (+5.90 Units / 53% ROI)
- Trey McBride has hit the Receptions Over in 11 of his last 16 games (+5.70 Units / 30% ROI)
- Marvin Harrison Jr. has hit the Receptions Under in 8 of his last 11 games (+5.15 Units / 40% ROI)
Anytime Touchdown Scorer Bet for Cardinals vs Seahawks
| Player Name | Anytime TD Odds |
|---|---|
| Jadarian Price | +115 |
| Jaxon Smith-Njigba | +125 |
| George Holani | +155 |
| Trey McBride | +175 |
| Jeremiyah Love | +175 |
Receiving Props: Total Receiving Yards for Cardinals vs Seahawks
| Player Name | Over | Under |
|---|---|---|
| Jaxon Smith-Njigba | 81.5 -115 | 81.5 -115 |
| Trey McBride | 62.5 -111 | 62.5 -118 |
| Michael Wilson | 40.5 -115 | 40.5 -115 |
| Marvin Harrison Jr. | 36.5 -115 | 36.5 -115 |
| Jeremiyah Love | 14.5 -120 | 14.5 -110 |
Rushing Props: Total Rushing Yards for Cardinals vs Seahawks
| Player Name | Over | Under |
|---|---|---|
| Jadarian Price | 58.5 -115 | 58.5 -115 |
| Jeremiyah Love | 36.5 -115 | 36.5 -115 |
Seahawks Best Bets:
- The Seattle Seahawks have hit the Moneyline in 16 of their last 21 games (+10.75 Units / 19% ROI)
- The Seattle Seahawks have hit the 1Q Moneyline in 12 of their last 21 games (+8.79 Units / 25% ROI)
- The Seattle Seahawks have covered the Spread in 13 of their last 21 games (+6.40 Units / 28% ROI)
- The Seattle Seahawks have hit the 3Q Moneyline in 10 of their last 18 games (+5.45 Units / 17% ROI)
- The Seattle Seahawks have hit the 1H Moneyline in 6 of their last 10 away games (+4.20 Units / 25% ROI)
Cardinals Best Bets:
- The Arizona Cardinals have hit the 4Q Game Total Over in 11 of their last 16 games (+5.50 Units / 30% ROI)
- The Arizona Cardinals have hit the 1Q Game Total Over in 6 of their last 7 games at home (+4.90 Units / 59% ROI)
- The Arizona Cardinals have covered the 1Q Spread in 11 of their last 17 games (+4.20 Units / 19% ROI)
- The Arizona Cardinals have hit the 1H Team Total Over in 5 of their last 6 games at home (+4.00 Units / 56% ROI)
- The Arizona Cardinals have hit the 1H Game Total Over in 12 of their last 19 games (+3.85 Units / 17% ROI)
Seahawks Against the Spread (ATS) Record
Against the spread this NFL season, the Seahawks are 0-0 (+0 Units / 0% ROI).
- Seahawks are 1-0 when betting on the Moneyline for +1 Units / 57.14% ROI
- Seahawks are 0-1 when betting the Over for -1.1 Units / -100% ROI
- SeahawksSeahawksSeahawks are 1-0 when betting the Under for +1 Units / 90.91% ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals are 1-0 (+1 Units / 90.91% ROI).
- Cardinals are 1-0 when betting on the Moneyline for +3.8 Units / 380% ROI
- Cardinals are 0-1 when betting the Over for -1.1 Units / -100% ROI
- Cardinals are 1-0 when betting the Under for +1 Units / 90.91% ROI
Seattle Seahawks: Keys to the Game vs. the Arizona Cardinals
The Seahawks are 11-3 (.786) when allowing less than 3 sacks since the 2025 season — 8th-best in NFL. The Cardinals have averaged just 1.8 sacks per game over that time span — T-3rd-worst in NFL.
The Seahawks are 3-1 (.750) when not forcing a turnover since the 2025 season — T-best in NFL; League Avg: .260.
The Seahawks are 15-1 (.938) when allowing less than 50% of third down conversion opportunities since the 2025 season — best in NFL; League Avg: .550.
The Seahawks are 11-1 (.917) when allowing less than 5 explosive passes since the 2025 season — best in NFL; League Avg: .560.
Arizona Cardinals: Keys to the Game vs. the Seattle Seahawks
The Cardinals were 1-8 (.111) when throwing at least 1 interception last season — T-4th-worst in NFL. The Seahawks intercepted 18 passes last season — 5th-most in NFL.
The Cardinals are 1-7 (.125) at home since the 2025 season — 2nd-worst in NFL; League Avg: .543.
The Cardinals are 1-10 (.091) when allowing 7 or more explosive plays since the 2025 season — 2nd-worst in NFL; League Avg: .402.
The Cardinals are winless (0-12) after a loss since the 2025 season — worst in NFL; League Avg: .413.
Additional Matchup Notes for Seattle Seahawks vs. Arizona Cardinals
The Cardinals have been successful on just 39.8% of rush attempts since the 2025 season — 5th-worst in NFL. The Seahawks have allowed a success rate of just 38.1% on rush attempts since the 2025 season — 2nd-best in NFL.
The Cardinals have been successful on just 37.1% of rush attempts with motion since the 2025 season — 4th-worst in NFL. The Seahawks have allowed a success rate of just 36.7% on rush attempts against motion since the 2025 season — T-3rd-best in NFL.
Cardinals RBs rushed for 10 or more yards on just 8.2% of 292 carries last season — 5th-worst in NFL. The Seahawks allowed 10+ yards on just 4.9% of carries to RBs last season — best in NFL.
The Seahawks have averaged 0.53 epa per play against open coverage since the 2025 season — T-3rd-best in NFL. The Cardinals have allowed 0.49 epa per play with open coverage since the 2025 season — T-5th-worst in NFL.
The Seahawks scored on 45.9% of their drives last season — 5th-best in NFL. The Cardinals defense allowed scores on 48.1% of opponent drives last season — 2nd-worst in NFL.
The Seahawks have been successful on 36.6% of pass attempts when their QB was under pressure since the 2025 season — 3rd-best in NFL. The Cardinals have pressured opposing QBs on just 20.4% of passing plays since the 2025 season — 4th-worst in NFL.
Seattle Seahawks Offense: Important Stats
The Seahawks have averaged 10.8 yards per play on play action passes since the 2025 season — best in NFL; League Avg: 7.3.
The Seahawks averaged 10.7 yards per play on play action passes last season — best in NFL; League Avg: 7.3.
The Seahawks have averaged 11.0 yards per play against open coverage since the 2025 season — best in NFL; League Avg: 9.1.
The Seahawks averaged 8.8 yards per play when their QB was scrambling last season — best in NFL; League Avg: 4.6.
Arizona Cardinals Offense: Important Stats
The Cardinals have targeted TEs 34% of the time (231 Pass Attempts/686 plays) since the 2025 season — highest in NFL; League Avg: 23%.
The Cardinals ran the ball on 31% of plays (48 carries/154 plays) in the red zone last season — lowest in NFL; League Avg: 49%.
The Cardinals ran the ball on 34% of plays (363 carries/1,074 plays) last season — lowest in NFL; League Avg: 43%.
The Cardinals have thrown the ball 60% of the time (686 Pass Attempts/1,146 plays) since the 2025 season — 2nd-highest in NFL; League Avg: 52%.
Seattle Seahawks Defense: Important Stats
The Seahawks defense has stuffed 49% (17/35) of rushing attempts on 3rd and short since the 2025 season — best in NFL; League Avg: 22%.
The Seahawks defense has allowed successful plays on 31% of rush attempts in the 1st quarter since the 2025 season — best in NFL; League Avg: 44%.
The Seahawks defense stuffed 48% (16/33) of rushing attempts on 3rd and short last season — best in NFL; League Avg: 22%.
The Seahawks defense have allowed -0.16 epa per play against play action passes since the 2025 season — T-best in NFL; League Avg: 0.07.
Arizona Cardinals Defense: Important Stats
36% of the plays ran against the Cardinals were in the red zone in the 1st half in Week 1 — worst in NFL; League Avg: 12%.
20% of the plays run against the Cardinals have been in the red zone since the 2025 season — worst in NFL; League Avg: 15%.
Offenses that faced the Cardinals defense did not target running backs on 0 pass attempts in Week 1 — lowest in NFL; League Avg: 17%.
The Cardinals defense have forced three and outs on 14% of opponent drives since the 2025 season — worst in NFL; League Avg: 20%.
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More NFL Betting Predictions:
- Anytime & First Touchdown Scorer Predictions
- Receiving Yards Prop Predictions
- Rushing Yards Prop Predictions
- Passing Yards Prop Predictions
- Receptions Made Prop Predictions
- Rushing Attempts Prop Predictions
- Passing Touchdowns Prop Predictions
- QB Interception Prop Predictions
- Field Goals Made Prop Predictions
- NFL Betting Previews: Every Game
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