Titans vs Colts Prediction, Odds & Best Prop Bets – NFL, Week 8

BetMGM Betting Oct 26, 2025, 10:20 AM

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A general overall interior view of Lucas Oil Stadium as Chicago Bears take on the Indianapolis Colts during an NFL football game, Sunday, Sept. 22, 2024, in Indianapolis. The Colts defeated the Bears 21-16. (AP Photo/Zach Bolinger)

(AP Photo/Zach Bolinger)

The Colts are -14 point favorites vs the Titans
Total (Over/Under): 47 points
Watch this game on CBS

The Tennessee Titans (1-6-0) visit Lucas Oil Stadium to take on the Indianapolis Colts (6-1-0) on Oct. 26. Kickoff is scheduled for 4:25pm EDT in Indianapolis, IN.

The Colts are betting favorites in this matchup, with the spread sitting at -14 (-110).

The Titans vs. Colts Over/Under is 47 total points for the game.

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Titans vs. Colts Odds, Spread, Over/Under

	Spread	Total (O/U)	Moneyline
Titans	+14 -110	47 -110	750
Colts	-14 -110	47 -110	-1200

Titans vs. Colts Prediction

The winning team model predicts the Colts will win this game with 77.0% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.

Titans vs Colts Spread Prediction

Based on recent against-the-spread trends, the model predicts the Colts will cover the spread with 51.5% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.

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We’ve highlighted some favorite NFL player prop bets for Titans players this game, looking at profitable historical betting trends:

Best Titans Player Prop Bets Today

Cameron Ward has hit the Interceptions Over in his last 5 games (+5.00 Units / 74% ROI)
Cameron Ward has hit the Longest Rush Under in 6 of his last 7 games (+4.95 Units / 63% ROI)
Gunnar Helm has hit the Receptions Over in 4 of his last 5 games (+4.90 Units / 92% ROI)
Cameron Ward has hit the TD Passes Under in 5 of his last 7 games (+4.60 Units / 47% ROI)
Tony Pollard has hit the Rushing Yards Under in 11 of his last 17 games (+4.10 Units / 21% ROI)

And here are some top NFL player prop bets for Colts players for this matchup, looking at profitable historical betting trends:

Best Colts Player Prop Best Bets Today

Alec Pierce has hit the Receiving Yards Over in 11 of his last 14 games (+7.60 Units / 47% ROI)
Alec Pierce has hit the Longest Reception Over in his last 5 games (+5.00 Units / 86% ROI)
Michael Pittman has hit the Receptions Over in 11 of his last 16 games (+4.15 Units / 19% ROI)
Jonathan Taylor has hit the Rushing Yards Over in 11 of his last 17 games (+4.10 Units / 21% ROI)
Adonai Mitchell has hit the Receptions Under in 8 of his last 12 games (+4.05 Units / 25% ROI)

Titans Best Bets:

The Tennessee Titans have hit the Game Total Over in 13 of their last 21 games (+4.20 Units / 18% ROI)
The Tennessee Titans have covered the 4Q Spread in 11 of their last 18 games (+3.50 Units / 17% ROI)
The Tennessee Titans have hit the 4Q Game Total Over in 11 of their last 18 games (+3.10 Units / 16% ROI)
The Tennessee Titans have hit the 4Q Moneyline in 7 of their last 18 games (+2.74 Units / 14% ROI)
The Tennessee Titans have hit the 1H Team Total Under in 12 of their last 20 games (+2.30 Units / 10% ROI)

Colts Best Bets:

The Indianapolis Colts have hit the 1H Team Total Over in 15 of their last 20 games (+10.20 Units / 41% ROI)
The Indianapolis Colts have hit the 2Q Game Total Over in 13 of their last 17 games (+8.40 Units / 41% ROI)
The Indianapolis Colts have hit the Game Total Over in 13 of their last 20 games (+6.40 Units / 29% ROI)
The Indianapolis Colts have covered the 2Q Spread in 7 of their last 8 games at home (+5.75 Units / 56% ROI)
The Indianapolis Colts have hit the 2Q Moneyline in 5 of their last 8 games at home (+4.00 Units / 34% ROI)

Titans Against the Spread (ATS) Record

Against the spread this NFL season, the Titans are 2-5 (-3.5 Units / -45.45% ROI).

Titans are 1-6 when betting on the Moneyline for -2.6 Units / -37.14% ROI
Titans are 4-3 when betting the Over for +0.7 Units / 9.09% ROI
Titans are 3-4 when betting the Under for -1.4 Units / ROI

Colts Against the Spread (ATS) Record

Against the spread this NFL season, the Colts are 5-2 (+2.8 Units / 36.36% ROI).

Colts are 6-1 when betting on the Moneyline for +5.25 Units / 36.84% ROI
Colts are 4-3 when betting the Over for +0.7 Units / 9.09% ROI
Colts are 3-4 when betting the Under for -1.4 Units / -18.18% ROI

Tennessee Titans: Keys to the Game vs. the Indianapolis Colts

The Titans have averaged -0.37 epa per play on motion plays this season — worst in NFL; League Avg: 0.04.

The Titans are averaging 12.8 drives per TD this season — worst Drives Per TD rate in NFL; League Avg: 4.3.

The Titans have averaged -0.50 epa per play on motion plays since Week 4 — worst in NFL; League Avg: 0.05.

The Titans have averaged -0.20 epa per play this season — worst in NFL; League Avg: 0.00.

Indianapolis Colts: Keys to the Game vs. the Tennessee Titans

The Titans are 4-14 (.222) when throwing at least 1 interception since the 2024 season — 9th-worst in NFL. The Colts have intercepted 25 passes since the 2024 season — 3rd-most in NFL.

The Titans are winless (0-4) when allowing 5 or more explosive passes this season — T-worst in NFL; League Avg: .410.

The Titans are winless (0-3) after a win since the 2024 season — T-worst in NFL; League Avg: .569.

The Titans are 1-6 (.143) when committing 1 or more turnovers this season — 9th-worst in NFL; League Avg: .356.

Additional Matchup Notes for Tennessee Titans vs. Indianapolis Colts