Alabama vs Mississippi State Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 5

Mississippi State quarterback Kamario Taylor (1) looks on during the second half against Wake Forest in the Duke's Mayo Bowl NCAA college football game, Friday, Jan. 2, 2026, in Charlotte, N.C.
(AP Photo/Scott Kinser)
Sportsbook Promos This Week
  • The Alabama Crimson Tide are a -4 point favorite vs. the Mississippi State Bulldogs
  • Alabama vs. Mississippi State Total (Over/Under): 59.5 points
  • TV Channel: ABC

Alabama (4-0) visit Davis Wade Stadium at Scott Field to take on Mississippi State (4-0) on Oct. 3 in Starkville, MS. Kickoff is scheduled for 12:00 pm.

The Alabama Crimson Tide are betting favorites in Week 5, with the spread sitting at -4 (-145).

The Alabama vs. Mississippi State Over/Under is 59.5 total points.

Bet now on Mississippi State Bulldogs vs Alabama Crimson Tide & all NCAAF games with BetMGM

Alabama vs. Mississippi State Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Alabama-4 -14559.5 -110-235
Mississippi State +4 +11059.5 -120+190

Alabama vs Mississippi State Prediction:

The winning team model predicts Alabama will win this game with 56.5% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Alabama Crimson Tide and the Mississippi State Bulldogs, key player performances this season and recent team trends.

Alabama vs Mississippi State Spread Prediction:

Based on recent against-the-spread trends, the model predicts Alabama will cover the spread with 51.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Mississippi State Bulldogs vs Alabama Crimson Tide and all games with BetMGM


  • Alabama has hit the Moneyline in 11 of their last 14 games (+6.80 Units / 8% ROI)
  • Alabama have covered the Spread in 9 of their last 15 games (+3.50 Units / 21% ROI)
  • Alabama has hit the 1Q Game Total Over in 4 of their last 6 away games (+2.75 Units / 38% ROI)
  • Alabama has hit the Game Total Under in 9 of their last 15 games (+2.40 Units / 15% ROI)
  • Alabama have covered the 1H Spread in 9 of their last 15 games (+1.85 Units / 10% ROI)
  • Mississippi State has hit the 1Q Moneyline in 7 of their last 12 games (+5.05 Units / 25% ROI)
  • Mississippi State has hit the 1Q Game Total Over in 5 of their last 6 games at home (+3.90 Units / 55% ROI)
  • Mississippi State has hit the Team Total Over in 8 of their last 12 games (+3.60 Units / 26% ROI)
  • Mississippi State have covered the 1Q Spread in 8 of their last 12 games (+3.20 Units / 23% ROI)
  • Mississippi State has hit the Game Total Over in 4 of their last 6 games at home (+1.80 Units / 27% ROI)

Alabama Against the Spread (ATS) Record

Alabama Crimson Tide is 3-1 against the spread this college football season (+1.9 Units / 43.18% ROI).

  • Alabama is 4-0 when betting on the Moneyline for +4 Units / 6.51% ROI
  • Alabama is 4-0 when betting the Over for +4 Units / 90.91% ROI
  • Alabama is 0-4 when betting the Under for -4.4 Units / -100% ROI

Mississippi State Against the Spread (ATS) Record

Mississippi State Bulldogs is 4-0 against the spread this college football season (+4 Units / 91.95% ROI).

  • Mississippi State is 4-0 when betting on the Moneyline for +4.4 Units / 10.05% ROI
  • Mississippi State is 2-2 when betting the Over for -0.15 Units / -3.45% ROI
  • Mississippi State is 2-2 when betting the Under for -0.2 Units / -4.49% ROI

Alabama: Keys to the Game vs. Mississippi State

Alabama is undefeated (8-0) when in a one score game since the 2024 season– T-best among Power Conference Teams; Average: .516

Alabama is 11-1 (.917) when rushing at least 4 yards in a play 10 or more times since the 2024 season– 6th-best in FBS; Average: .602

Alabama is undefeated (13-0) when intercepting at least 1 pass since the 2024 season– T-best in FBS; Average: .683

Alabama was 9-2 (.818) when averaging more than 5 yards on first down plays last season– T-10th-best among Power Conference Teams; Average: .632

Mississippi State: Keys to the Game vs. Alabama

Mississippi State was winless (0-5) when in a one score game last season– T-worst among Power Conference Teams; Average: .514

Mississippi State was 2-8 (.200) when having a turnover margin within one of the opposing team last season– 3rd-worst among Power Conference Teams; Average: .578

Mississippi State was winless (0-8) when allowing 200 or more passing yards last season– T-worst among Power Conference Teams; Average: .498

Mississippi State was winless (0-6) when throwing at least 1 interception last season– T-worst among Power Conference Teams; Average: .443

Matchup Notes for Alabama vs. Mississippi State

Mississippi State’s WRs gained 2,413 yards on 163 receptions (14.8 YPR) last season — T-3rd-best among SEC WRs. Alabama’s defense allowed just 10.4 Yards Per Reception last season — best among SEC defenses.

Mississippi State’s TEs gained 423 yards on 44 receptions (just 9.6 YPR) last season — 4th-worst among SEC TEs. Alabama’s defense allowed just 10.4 Yards Per Reception last season — T-16th-best among FBS defenses.

Mississippi State’s WRs gained 2,413 yards on 163 receptions (14.8 YPR) last season — T-3rd-best among SEC WRs. Alabama’s defense allowed just 11.9 Yards Per Reception to WRs last season — T-26th-best among FBS defenses.

Alabama had 2.1 receiving touchdowns per game last season — T-2nd-best among SEC skill players. Mississippi State’s defense allowed 1.8 receiving touchdowns per game last season — T-worst among SEC defenses.

Alabama had 2.1 receiving touchdowns per game last season — T-2nd-best among SEC skill players. Mississippi State’s defense allowed 1.8 receiving touchdowns per game last season — T-27th-worst among FBS defenses.

Alabama’s TEs has gained 1,464 yards on 124 receptions (11.8 YPR) since the 2024 season — T-5th-best among SEC TEs. Mississippi State’s defense has allowed just 9.1 Yards Per Reception to TEs since the 2024 season — T-8th-best among FBS defenses.

Alabama Offensive Stats & Trends

Alabama QBs have 7 completions for 20 or more yards with over 10 yards to go this season– T-most among FBS Teams

Alabama have thrown 8 TDs and no interceptions in the 4th quarter since the 2024 season– T-2nd-best among FBS Offenses; Average: 1.7

Alabama Skill Players averaged 20.7 yards per reception (497 yards/24 catches) on 3rd and long last season– best among FBS Teams; Average: 12.9

Alabama Skill Players averaged 20.7 yards per reception (497 yards/24 catches) on 3rd and long last season– best among Power Conference Teams; Average: 13.1

Alabama WRs averaged 29.0 yards per reception (348 yards/12 catches) on 3rd and long last season– best among Power Conference Teams; Average: 14.8

Mississippi State Offensive Stats & Trends

Mississippi State’s WRs gained 2,413 yards on 163 receptions (14.8 YPR) last season — T-3rd-best among SEC WRs. Alabama’s defense allowed just 10.4 Yards Per Reception last season — best among SEC defenses.

Mississippi State WRs averaged a touchdown every 5.0 receptions (10 Rec/2 TDs) in the Red Zone last season– worst Receptions Per TD among SEC Teams; Average: 2.1

Mississippi State’s TEs gained 423 yards on 44 receptions (just 9.6 YPR) last season — 4th-worst among SEC TEs. Alabama’s defense allowed just 10.4 Yards Per Reception last season — T-16th-best among FBS defenses.

Mississippi State’s WRs gained 2,413 yards on 163 receptions (14.8 YPR) last season — T-3rd-best among SEC WRs. Alabama’s defense allowed just 11.9 Yards Per Reception to WRs last season — T-26th-best among FBS defenses.

Mississippi State WRs have caught 13 touchdown passes this season– most among SEC Teams

Alabama Defensive Stats & Trends

Alabama has allowed first downs on 8% of pass attempts in the Red Zone since the 2024 season– best in the SEC; Average: 20%

Alabama has allowed first downs on 18% of pass attempts on 3rd down this season– best in the SEC; Average: 32%

Alabama allowed just 10.0 yards per completion (2,369 yards/236 completions) last season– 2nd-best in the SEC; Average: 11.7

Alabama has allowed passes of 40+ yards on 5 of 112 attempts (4%) this season– worst in the SEC; Average: 2%

Alabama allowed 10 rushing TDs on 487 carries (48.7 Carries Per TD) last season– 5th-best in FBS; Average: 23.2

Mississippi State Defensive Stats & Trends

Mississippi State allowed 216.9 rushing yards per game (2,603/12) last season– worst in the SEC; Average: 131.4

Mississippi State averaged a sack every 34.1 pass attempts (341 Pass Attempts/10 Sacks) last season– 2nd-worst among Power Conference Teams; Average: 14.1

Mississippi State has sacked opponents 4 times in the Red Zone this season– T-most in FBS

Mississippi State allowed 456.4 yards from scrimmage per game last season– worst in the SEC; Average: 341.3

Mississippi State tackled opponents for a loss on just 52 of 523 rushing attempts (10% TFL%) last season– worst among Power Conference Teams; Average: 16%.


Bet now on Mississippi State Bulldogs vs Alabama Crimson Tide and all games with BetMGM


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