USC vs Indiana Prediction, Odds & Best Prop Bets – NCAAF, Week 11

Indiana head coach Curt Cignetti watches from the sideline as his team plays Michigan during the first half of an NCAA college football game in Bloomington, Ind., Saturday, Nov. 9, 2024.
(AP Photo/AJ Mast)
  • The Indiana Hoosiers are a -7 point favorite vs. the USC Trojans
  • USC vs. Indiana Total (Over/Under): 49.5 points
  • TV Channel: CBS

USC (7-2) visit Memorial Stadium (Bloomington, IN) to take on Indiana (8-1) on Nov. 14 in Bloomington, IN. Kickoff is scheduled for 3:30 pm.

The Indiana Hoosiers are betting favorites in Week 11, with the spread sitting at -7 (-125).

The USC vs. Indiana Over/Under is 49.5 total points.

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USC vs. Indiana Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
USC+7 -10549.5 -110+230
Indiana -7 -12549.5 -120-285

USC vs Indiana Prediction:

The winning team model predicts Indiana will win this game with 63.9% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the USC Trojans and the Indiana Hoosiers, key player performances this season and recent team trends.

USC vs Indiana Spread Prediction:

Based on recent against-the-spread trends, the model predicts Indiana will cover the spread with 58.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Indiana has hit the Moneyline in 11 of their last 12 games (+10.55 Units / 6% ROI)
  • Indiana has hit the 1H Game Total Under in 12 of their last 15 games (+8.50 Units / 50% ROI)
  • Indiana has hit the 1Q Moneyline in 6 of their last 9 games at home (+5.00 Units / 1% ROI)
  • Indiana has hit the Team Total Under in 10 of their last 15 games (+4.35 Units / 26% ROI)
  • Indiana has hit the 1Q Game Total Under in 9 of their last 15 games (+2.79 Units / 16% ROI)
  • USC has hit the 1Q Game Total Under in 9 of their last 13 games (+4.80 Units / 33% ROI)
  • USC has hit the Moneyline in 8 of their last 12 games (+3.75 Units / 3% ROI)
  • USC has hit the Game Total Over in 3 of their last 5 away games (+0.75 Units / 14% ROI)
  • USC has hit the 1H Game Total Over in 3 of their last 5 away games (+0.70 Units / 12% ROI)
  • USC has hit the Team Total Over in 3 of their last 5 away games (+0.60 Units / 10% ROI)

USC Against the Spread (ATS) Record

USC Trojans is 3-6 against the spread this college football season (-3.6 Units / -36.36% ROI).

  • USC is 6-2 when betting on the Moneyline for +4.65 Units / 4.68% ROI
  • USC is 4-5 when betting the Over for -1.55 Units / -15.58% ROI
  • USC is 5-4 when betting the Under for +0.6 Units / 6.09% ROI

Indiana Against the Spread (ATS) Record

Indiana Hoosiers is 1-8 against the spread this college football season (-7.77 Units / -78.72% ROI).

  • Indiana is 5-1 when betting on the Moneyline for +4 Units / 6.56% ROI
  • Indiana is 3-6 when betting the Over for -3.56 Units / -36.11% ROI
  • Indiana is 6-3 when betting the Under for +2.7 Units / 27.16% ROI

USC: Keys to the Game vs. Indiana

USC is undefeated (10-0) when not throwing an interception since the 2024 season– T-best among Power Conference Teams; Average: .722

USC is 13-4 (.765) when rushing more than 30 times since the 2024 season– T-32nd-best in FBS; Average: .629

USC is undefeated (13-0) when making 3 or more explosive runs in a game since the 2024 season– T-best in FBS; Average: .649

USC is 13-2 (.867) when rushing for 120 or more yards since the 2024 season– T-24th-best in FBS; Average: .691

Indiana: Keys to the Game vs. USC

Indiana is 22-1 (.957) when allowing less than 5 yards per rush since the 2024 season– best in FBS; Average: .625

Indiana was winless (0-7) when their opponent committed less than 60 yards in penalties in the 2023 season– worst among Power Conference Teams; Average: .576

Indiana is 10-1 (.909) when the opposing team rushes more than 30 times since the 2024 season– best among Power Conference Teams; Average: .484

Indiana is 18-1 (.947) when passing for more than 200 yards since the 2024 season– 2nd-best among Power Conference Teams; Average: .643

Matchup Notes for USC vs. Indiana

Indiana’s offense threw for 20 or more yards on 13.9% of 404 attempts last season — 10th-best among FBS offenses. USC’s defense allowed 20+ yards on just 8.1% of attempts last season — T-29th-best among FBS defenses.

Indiana’s WRs gained 3,149 yards on 229 receptions (13.8 YPR) last season — T-5th-best among Big Ten WRs. USC’s defense allowed just 10.4 Yards Per Reception last season — T-16th-best among FBS defenses.

Indiana’s WRs gained 3,149 yards on 229 receptions (13.8 YPR) last season — T-5th-best among Big Ten WRs. USC’s defense allowed just 12.0 Yards Per Reception to WRs last season — T-29th-best among FBS defenses.

USC’s WRs gained 2,759 yards on 185 receptions (14.9 YPR) last season — 2nd-best among Big Ten WRs. Indiana’s defense allowed just 11.9 Yards Per Reception to WRs last season — T-26th-best among FBS defenses.

USC’s WRs gained 2,759 yards on 185 receptions (14.9 YPR) last season — T-16th-best among FBS WRs. Indiana’s defense allowed just 11.9 Yards Per Reception to WRs last season — T-26th-best among FBS defenses.

USC’s WRs gained 2,759 yards on 185 receptions (14.9 YPR) last season — 2nd-best among Big Ten WRs. Indiana’s defense allowed just 10.0 Yards Per Reception last season — T-5th-best among FBS defenses.

USC Offensive Stats & Trends

USC TEs had no touchdowns on 33 receptions last season– worst Receptions Per TD among Power Conference Teams; Average: 10.3

USC TEs gained no yards on 1 catches (0.0 YPR) on 3rd and long last season– worst among Big Ten Teams; Average: 11.0

USC WRs caught 9 touchdown passes in the 4th quarter last season– most among Big Ten Teams

USC TEs had no touchdowns on 5 receptions in the Red Zone last season– T-worst Receptions Per TD among Power Conference Teams; Average: 2.0

USC have averaged 19.0 yards per completion (418 yards/22 completions) with over 10 yards to go this season– 4th-best among FBS Offenses; Average: 12.0

Indiana Offensive Stats & Trends

Indiana threw for 29 TDs in the Red Zone last season– most among FBS Offenses

Indiana threw for 15 TDs in the 3rd quarter last season– most among FBS Offenses

Indiana TEs had no receptions on 2 targets on 3rd down last season– worst among Power Conference Teams; Average: 59%

Indiana threw for 46 TDs last season– most among FBS Offenses

Indiana threw 6.6 Passing TDs per Interception (46 passing TDs/7 interceptions) last season– 4th-best among FBS Offenses; Average: 2.0

USC Defensive Stats & Trends

USC allowed 4.4 touchdowns per interception (31 TDs allowed, and 7 INT) in the 2023 season– worst in the Big Ten; Average: 1.6

USC has allowed opponents to catch 21 of 29 passes (72% Reception Pct) on 3rd and long this season– worst in the Big Ten; Average: 52%

USC has allowed a Completion Pct of 77% (24 completions/31 attempts) when opponents had over 10 yards to go this season– worst among Power Conference Teams; Average: 61%

USC has tackled opponents for a loss on just 11 of 134 rushing attempts (8% TFL%) in the Red Zone since the 2024 season– T-6th-worst in FBS; Average: 14%.

USC tackled opponents for a loss on just 49 of 403 rushing attempts (12% TFL%) last season– 5th-worst among Power Conference Teams; Average: 16%.

Indiana Defensive Stats & Trends

Indiana has tackled opponents for a loss on 171 of 710 rushing attempts (24% TFL%) since the 2024 season– best in the Big Ten; Average: 16%.

Indiana opponents has averaged 10.0 Passing Attempts per TD (30 Pass Attempts/3 Passing TDs) in the Red Zone this season– best in the Big Ten; Average: 3.9

Indiana opponents has averaged 7.5 Passing Attempts per TD (60 Pass Attempts/8 Passing TDs) in the Red Zone since the 2024 season– best in the Big Ten; Average: 3.9

Indiana has tackled opponents for a loss on 171 of 710 rushing attempts (24% TFL%) since the 2024 season– best in FBS; Average: 15%.

Indiana has sacked opponents 5 times in the Red Zone this season– most in the Big Ten


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