Iowa vs Northwestern Prediction, Odds & Best Prop Bets – NCAAF, Week 10

Northwestern head coach David Braun gestures during the first half of an NCAA college football game against Southern California, Friday, Nov. 7, 2025, in Los Angeles. (AP Photo/Mark J. Terrill)
(AP Photo/Mark J. Terrill)
  • The Northwestern Wildcats are a -1.5 point favorite vs. the Iowa Hawkeyes
  • Iowa vs. Northwestern Total (Over/Under): 42.5 points
  • TV Channel: FOX

Iowa (6-2) visit Ryan Field to take on Northwestern (6-2) on Nov. 7 in Evanston, IL. Kickoff is scheduled for 7:30 pm.

The Northwestern Wildcats are betting favorites in Week 10, with the spread sitting at -1.5 (-130).

The Iowa vs. Northwestern Over/Under is 42.5 total points.

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Iowa vs. Northwestern Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Iowa+1.5 -10242.5 +125+110
Northwestern -1.5 -13042.5 -165-135

Iowa vs Northwestern Prediction:

The winning team model predicts Northwestern will win this game with 52.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Iowa Hawkeyes and the Northwestern Wildcats, key player performances this season and recent team trends.

Iowa vs Northwestern Spread Prediction:

Based on recent against-the-spread trends, the model predicts Northwestern will cover the spread with 51.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Northwestern Wildcats vs Iowa Hawkeyes and all games with BetMGM


  • Iowa has hit the 1H Moneyline in 8 of their last 13 games (+5.95 Units / 1% ROI)
  • Iowa have covered the Spread in 9 of their last 13 games (+4.60 Units / 32% ROI)
  • Iowa has hit the Game Total Under in 9 of their last 13 games (+4.60 Units / 32% ROI)
  • Iowa has hit the Team Total Over in 5 of their last 6 away games (+3.95 Units / 56% ROI)
  • Iowa has hit the 1Q Moneyline in 7 of their last 13 games (+3.20 Units / 2% ROI)
  • Northwestern have covered the 1Q Spread in 11 of their last 13 games (+9.35 Units / 65% ROI)
  • Northwestern has hit the Team Total Over in their last 8 games at home (+8.00 Units / 87% ROI)
  • Northwestern has hit the 1Q Moneyline in 6 of their last 8 games at home (+6.00 Units / 13% ROI)
  • Northwestern has hit the Moneyline in 6 of their last 7 games at home (+5.30 Units / 23% ROI)
  • Northwestern have covered the Spread in 6 of their last 8 games at home (+3.80 Units / 43% ROI)

Iowa Against the Spread (ATS) Record

Iowa Hawkeyes is 5-3 against the spread this college football season (+1.7 Units / 19.43% ROI).

  • Iowa is 4-2 when betting on the Moneyline for +1.2 Units / 8.92% ROI
  • Iowa is 2-6 when betting the Over for -4.6 Units / -52.27% ROI
  • Iowa is 6-2 when betting the Under for +3.8 Units / 42.65% ROI

Northwestern Against the Spread (ATS) Record

Northwestern Wildcats is 5-3 against the spread this college football season (+1.74 Units / 19.75% ROI).

  • Northwestern is 5-2 when betting on the Moneyline for +3.3 Units / 16.5% ROI
  • Northwestern is 4-3 when betting the Over for +0.75 Units / 8.46% ROI
  • Northwestern is 3-4 when betting the Under for -1.39 Units / -15.72% ROI

Iowa: Keys to the Game vs. Northwestern

Iowa is undefeated (10-0) when making 7 or more explosive plays since the 2024 season– T-best among Power Conference Teams; Average: .688

Iowa is undefeated (12-0) when scoring 22 or more points since the 2024 season– T-best among Power Conference Teams; Average: .792

Iowa is undefeated (10-0) when making 7 or more explosive plays since the 2024 season– T-best in FBS; Average: .645

Iowa is 11-4 (.733) when allowing less than 5 explosive passes since the 2024 season– T-39th-best in FBS; Average: .603

Northwestern: Keys to the Game vs. Iowa

Northwestern was winless (0-6) when allowing more than 3 explosive runs last season– T-worst in FBS; Average: .414

Northwestern was winless (0-6) when allowing more than 3 explosive runs last season– T-worst among Power Conference Teams; Average: .459

Northwestern was winless (0-7) when allowing 120 or more rushing yards last season– T-worst in FBS; Average: .379

Northwestern was 1-8 (.111) when their opponent rushed more than 30 times last season– T-9th-worst in FBS; Average: .442

Matchup Notes for Iowa vs. Northwestern

Northwestern’s offense threw for 2,417 passing yards in 13 games (just 185.9 YPG) last season — 30th-worst among FBS offenses. Iowa’s defense allowed just 172.7 passing yards per game last season — 11th-best among FBS defenses.

Northwestern’s QBs threw for 2,417 passing yards in 13 games (just 185.9 YPG) last season — 30th-worst among FBS teams. Iowa’s defense allowed just 172.7 passing yards per game last season — 4th-best among Big Ten defenses.

Northwestern’s QBs threw for 2,417 passing yards in 13 games (just 185.9 YPG) last season — 30th-worst among FBS teams. Iowa’s defense allowed just 172.7 passing yards per game last season — 11th-best among FBS defenses.

Iowa’s offense threw for 1,861 passing yards in 13 games (just 143.2 YPG) last season — 9th-worst among FBS offenses. Northwestern’s defense allowed just 193.5 passing yards per game last season — 30th-best among FBS defenses.

Iowa’s RBs averaged just 6.0 yards after the catch last season — T-24th-worst among FBS RBs. Northwestern’s defense allowed 11.2 RAC last season — T-4th-worst among Big Ten defenses.

Iowa has 494 receptions in 34 games (just 14.5 per game) since the 2024 season — worst among Big Ten skill players. Northwestern’s defense has allowed 19.3 receptions per game since the 2024 season — 4th-worst among Big Ten defenses.

Iowa Offensive Stats & Trends

Iowa WRs have averaged just 8.7 yards per reception (139 yards/16 catches) on 3rd and long since the 2024 season– worst among Power Conference Teams; Average: 15.0

Iowa WRs have averaged just 9.0 receptions per game (72/8) this season– worst among Big Ten Teams; Average: 13.0

Iowa WRs averaged just 5.5 receptions per game (71/13) last season– worst among Power Conference Teams; Average: 12.6

Iowa WRs have averaged just 9.0 receptions per game (72/8) this season– 2nd-worst among Power Conference Teams; Average: 13.2

Iowa WRs have averaged just 8.7 yards per reception (139 yards/16 catches) on 3rd and long since the 2024 season– 2nd-worst among FBS Teams; Average: 14.3

Northwestern Offensive Stats & Trends

Northwestern TEs have averaged 16.6 yards per reception (480 yards/29 catches) this season– best among Big Ten Teams; Average: 10.8

Northwestern Skill Players averaged a touchdown every 30.0 receptions (210 Rec/7 TDs) last season– 2nd-worst Receptions Per TD among Power Conference Teams; Average: 11.7

Northwestern TEs have averaged 16.6 yards per reception (480 yards/29 catches) this season– best among Power Conference Teams; Average: 10.8

Northwestern WRs averaged a touchdown every 32.0 receptions (128 Rec/4 TDs) last season– worst Receptions Per TD among Big Ten Teams; Average: 10.7

Northwestern Skill Players averaged a touchdown every 30.0 receptions (210 Rec/7 TDs) last season– 2nd-worst Receptions Per TD among FBS Teams; Average: 11.7

Iowa Defensive Stats & Trends

Iowa allowed 4 rushing TDs on 54 carries (13.5 Carries Per TD) in the Red Zone last season– best in FBS; Average: 4.6

Iowa did not record a sack (38 pass attempts) in the Red Zone last season– worst in the Big Ten; Average: 14.3

Iowa has allowed 2 rushing TDs on 261 carries (130.5 Carries Per TD) this season– best among Power Conference Teams; Average: 27.4

Iowa allowed 4 rushing TDs on 54 carries (13.5 Carries Per TD) in the Red Zone last season– best among Power Conference Teams; Average: 4.8

Iowa allowed 4 rushing TDs on 54 carries (13.5 Carries Per TD) in the Red Zone last season– best in the Big Ten; Average: 5

Northwestern Defensive Stats & Trends

Northwestern had no interceptions (0 pass attempts) in the Red Zone last season– T-worst in FBS; Average: 36.5

Northwestern had no interceptions (0 pass attempts) in the Red Zone last season– T-worst in the Big Ten; Average: 38.1

Northwestern allowed a Completion Pct of just 40% (16 completions/40 attempts) on 3rd and long last season– best among Power Conference Teams; Average: 54%

The Northwestern defense has allowed scores on 10% of opponent drives (3/30) in the 1st quarter this season– 8th-best in FBS; Average: 20%

Northwestern did not record a sack (31 pass attempts) last week– T-worst in the Big Ten; Average: 16.7


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