Latest Stories

Biggest NFL Upsets by Point Spread of Last 20 Years

Find out which 13 NFL teams have won a game as underdogs of at least 14 points. Read More

BetMGM Jul 14, 2025

Who is the Buffalo Billsโ€™ Defensive Coordinator?

Get information about the current Buffalo Bills defensive coordinator, along with his past roles in the NFL. Read More

Nick Hennion Jul 09, 2025

Bills vs. Ravens: NFL Week 1 Odds, Prediction

See the latest NFL Week 1 odds, picks and predictions for Bills vs. Ravens on September 7 at Highmark Stadium. Read More

Nick Hennion Jul 08, 2025

Who is the Buffalo Billsโ€™ Offensive Coordinator?

Get information about the Buffalo Billsโ€™ offensive coordinator, along with past NFL roles. Read More

Nick Hennion Jul 02, 2025

Bills Over Under Wins, 2025 NFL Win Totals

Get the latest 2025 Bills over under wins for their NFL season win total, along with their 2025 win total odds and win total predictions. Read More

Nick Hennion Jun 27, 2025

AFC East Odds, Prediction & Standings

Get my AFC East prediction, along with AFC East odds and standings, for the 2025 division winner based on NFL odds at BetMGM. Read More

Nick Hennion Jun 25, 2025

Josh Allen Yards & TDs This Season: Passing Odds

Bet on the regular-season passing yards and touchdown totals for Buffalo Bills quarterback Josh Allen. Read More

BetMGM Jun 24, 2025

Bills Backup QB: Betting Data, Stats & More

Who is the Buffalo Billsโ€™ backup QB? Get the information on Josh Allenโ€™s backup, along with stats and betting info. Read More

Nick Hennion Jun 10, 2025

Bills Playoff Chances, Predictions for 2025

Get implied probability for the Buffalo Bills playoff chances based on both preseason and live NFL odds for the 2025-26 NFL season. Read More

Nick Hennion May 20, 2025
Load More

Bills Week 1 Odds

Sep 7 - 7 pm EST

Ravens vs. Bills

How To Bet on Buffalo Bills Odds

BetMGM has updated NFL odds for the Buffalo Bills, including spreads, futures, and more.

  1. Visit theย NFL linesย page.
  2. Find odds for Buffalo in a futures market (e.g., Super Bowl odds) or game market (e.g., Bills vs. the Patriots).
  3. Add a bet to your Bet Slip.
  4. Add a Stake to see your potential payout.
  5. Place your bet!

If youโ€™re in New York, check out updated New York sportsbook promos for a potential Odds Boost, Parlay Boost, and more!

Buffalo Bills Futures Odds

Will the Bills win the division? Will an edge rusher go over his regular-season sacks total? How many wins will they have in the regular season?

For example: If you bet $10 on a player to go over his regular-season sacks total, the bet would settle when that player exceeds the total or ends the regular-season under the total.

Log in to your account today for updated Super Bowl odds and more futures.

Buffalo Bills Spread

When you bet on a Bills spread, youโ€™re betting on the final margin of the game.

For example: If you bet $35 on the Bills -11.5 (-110) against the New England Patriots, Buffalo must win the game by at least 12 points.

Alternatively, if you bet $35 on the Bills +5.5 (-105) against the New York Jets, Buffalo must lose by five or fewer points (or win the game).

If the scoring margin is identical to the spread (e.g., -3 or +6), the bet is aย push, and your money is refunded.

Buffalo Bills Moneyline

Will the Bills win the game? The margin of victory doesn’t matter in moneyline betting.

For example: If you bet $55 on the Bills -150 against the Arizona Cardinals, Buffalo must win the game.

If the game ends in a tie, the bet is a push.

Buffalo Bills Over/Under Total

How many combined points will be scored by both teams? The final result (win, loss, or tie) of the game is irrelevant.

For example: If you bet $100 on over 50.5 (-110) in the Billsโ€™ game against the Cincinnati Bengals, the teams must combine for at least 51 points.

Alternatively, if you bet $100 on under 50.5 (-110), the teams must combine for 50 or fewer points.

If the combined point total is identical to the over/under total, the bet is a push.

Buffalo Bills Parlays

You can combine Bills bets and other bets (NFL, NBA, or another sport) into one parlay for more entertainment and a bigger potential payout.

For example: If you bet $15 on a two-leg parlay with the Bills’ moneyline (-150) against the Cleveland Browns and the Tennessee Titans’ moneyline (+120) against the Chicago Bears, both legs must hit for the parlay to cash.

If one bet is a push, itโ€™s eliminated from the parlay, and odds (and payout) are recalculated without that leg. You can alsoย Cash Out early on a parlay betย (if available).

You can also build multi-sportย parlaysย andย NFL teaser betsย with odds from NFL games, MLB games, and more. And BetMGM offers theย best sportsbook promotionsย for parlays.

Buffalo Bills Prop Bets

How many passing touchdowns will a quarterback have in the game? Will the quarterback have at least one rushing touchdown?

BetMGM offers dozens of prop bets for each NFL game, including player prop bets for yardage totals, touchdowns, field goals, and more.

Podcast

KG Certified

NBA Hall of Famer Kevin Garnett brings you unrivaled weekly content on KG CERTIFIED.

NBA Hall of Famer Kevin Garnett brings you unrivaled weekly content on KG CERTIFIED.

View All Episodes

Podcast

You Better You Bet

Nick Kostos and Ken Barkley have you covered for the best bets on the biggest matchups.

Nick Kostos and Ken Barkley have you covered for the best bets on the biggest matchups.

View All Episodes

Podcast

FCS Football Talk

Sam Herder shares his FCS analysis, predictions, thoughts, and ramblings on the FCS Football Talk podcast, presented by HERO Sports and BetMGM.

Sam Herder shares his FCS analysis, predictions, thoughts, and ramblings on the FCS Football Talk podcast, presented by HERO Sports and BetMGM.

View All Episodes

Podcast

BetMGM Tonight

Betting previews and analysis with Ryan Horvat, Nick Ashooh, and Trysta Krick.

Betting previews and analysis with Ryan Horvat, Nick Ashooh, and Trysta Krick.

View All Episodes

Podcast

The Daily Tip

Michael Jenkins and Chelsa Messinger bring you early-morning sports betting analysis.

Michael Jenkins and Chelsa Messinger bring you early-morning sports betting analysis.

View All Episodes

Podcast

BetQL Daily

Daily sports betting analysis with Joe Ostrowski, Ed Egros, and Erin Hawksworth.

Daily sports betting analysis with Joe Ostrowski, Ed Egros, and Erin Hawksworth.

View All Episodes