LSU vs Ole Miss Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 3

Mississippi head coach Pete Golding walks the sideline against Georgia during the second half of the Sugar Bowl NCAA college football playoff quarterfinal game, Thursday, Jan. 1, 2026, in New Orleans. (AP Photo/Matthew Hinton Hinton)
(AP Photo/Matthew Hinton Hinton)
Sportsbook Promos This Week
  • The LSU Tigers are a -2.5 point favorite vs. the Ole Miss Rebels
  • LSU vs. Ole Miss Total (Over/Under): 58.5 points
  • TV Channel: ABC

LSU (2-0) visit Vaught-Hemingway Stadium to take on Ole Miss (2-0) on Sep. 19 in University, MS. Kickoff is scheduled for 7:30 pm.

The LSU Tigers are betting favorites in Week 3, with the spread sitting at -2.5 (-135).

The LSU vs. Ole Miss Over/Under is 58.5 total points.

Bet now on Ole Miss Rebels vs LSU Tigers & all NCAAF games with BetMGM

LSU vs. Ole Miss Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
LSU-2.5 -13558.5 -108-160
Ole Miss +2.5 +10058.5 -112+130

LSU vs Ole Miss Prediction:

The winning team model predicts LSU will win this game with 52.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the LSU Tigers and the Ole Miss Rebels, key player performances this season and recent team trends.

LSU vs Ole Miss Spread Prediction:

Based on recent against-the-spread trends, the model predicts LSU will cover the spread with 51.1% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Ole Miss Rebels vs LSU Tigers and all games with BetMGM


  • LSU has hit the 1Q Game Total Under in 3 of their last 5 away games (+1.90 Units / 31% ROI)
  • LSU has hit the 1H Moneyline in 6 of their last 11 games (+1.90 Units / 0% ROI)
  • LSU has hit the Game Total Under in 3 of their last 5 away games (+0.80 Units / 15% ROI)
  • LSU has hit the 1H Game Total Under in 3 of their last 5 away games (+0.75 Units / 13% ROI)
  • LSU has hit the Team Total Over in 3 of their last 5 away games (+0.55 Units / 9% ROI)
  • Ole Miss has hit the Moneyline in 9 of their last 11 games (+8.55 Units / 26% ROI)
  • Ole Miss has hit the 1H Moneyline in 10 of their last 13 games (+5.45 Units / 1% ROI)
  • Ole Miss has hit the 1H Game Total Under in 7 of their last 9 games at home (+4.80 Units / 46% ROI)
  • Ole Miss has hit the Team Total Over in 9 of their last 14 games (+3.38 Units / 20% ROI)
  • Ole Miss has hit the 1Q Game Total Under in 6 of their last 9 games at home (+2.90 Units / 28% ROI)

LSU Against the Spread (ATS) Record

LSU Tigers is 1-1 against the spread this college football season (-0.1 Units / -4.55% ROI).

  • LSU is 1-0 when betting on the Moneyline for +1 Units / 25.64% ROI
  • LSU is 2-0 when betting the Over for +2 Units / 90.91% ROI
  • LSU is 0-2 when betting the Under for -2.2 Units / -100% ROI

Ole Miss Against the Spread (ATS) Record

Ole Miss Rebels is 0-2 against the spread this college football season (-2.2 Units / -100% ROI).

  • Ole Miss is 1-0 when betting on the Moneyline for +1 Units / 40% ROI
  • Ole Miss is 1-1 when betting the Over for -0.1 Units / -4.55% ROI
  • Ole Miss is 1-1 when betting the Under for -0.1 Units / -4.55% ROI

LSU: Keys to the Game vs. Ole Miss

LSU was undefeated (6-0) when intercepting at least 1 pass last season– T-best in FBS; Average: .668

LSU was 4-1 (.800) when in a one score game last season– T-6th-best among Power Conference Teams; Average: .514

LSU was undefeated (6-0) when intercepting at least 1 pass last season– T-best among Power Conference Teams; Average: .688

LSU was 9-2 (.818) when converting 55% or more of its red zone chances into touchdowns last season– T-22nd-best in FBS; Average: .624

Ole Miss: Keys to the Game vs. LSU

Ole Miss was 2-1 (.667) when sacking the QB less than 3 times last season– T-12th-best among Power Conference Teams; Average: .468

Ole Miss was 9-2 (.818) when averaging more than 5 yards on first down plays last season– T-10th-best among Power Conference Teams; Average: .632

Ole Miss was 7-2 (.778) when having a turnover margin within one of the opposing team last season– 14th-best among Power Conference Teams; Average: .578

Ole Miss was 8-2 (.800) when their opponent rushed more than 30 times last season– T-5th-best in FBS; Average: .442

Matchup Notes for LSU vs. Ole Miss

Ole Miss’s WRs gained 3,679 yards on 248 receptions (14.8 YPR) last season — T-19th-best among FBS WRs. LSU’s defense allowed just 10.8 Yards Per Reception last season — T-34th-best among FBS defenses.

Ole Miss gained 4,692 yards on 339 receptions (13.8 YPR) last season — T-11th-best among FBS skill players. LSU’s defense allowed just 10.8 Yards Per Reception last season — T-34th-best among FBS defenses.

Ole Miss gained 4,692 yards on 339 receptions (13.8 YPR) last season — best among SEC skill players. LSU’s defense allowed just 10.8 Yards Per Reception last season — T-34th-best among FBS defenses.

LSU’s offense threw for 20 or more yards on just 7.0% of 443 attempts last season — T-9th-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-23rd-best among FBS defenses.

LSU’s TEs had 59 receptions in 13 games (4.5 per game) last season — T-2nd-best among SEC TEs. Ole Miss’s defense allowed just 17.3 receptions per game last season — 4th-best among SEC defenses.

LSU’s offense threw for 20 or more yards on just 7.0% of 443 attempts last season — T-9th-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-3rd-best among SEC defenses.

LSU Offensive Stats & Trends

LSU’s offense threw for 20 or more yards on just 7.0% of 443 attempts last season — T-9th-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-23rd-best among FBS defenses.

LSU’s TEs had 59 receptions in 13 games (4.5 per game) last season — T-2nd-best among SEC TEs. Ole Miss’s defense allowed just 17.3 receptions per game last season — 4th-best among SEC defenses.

LSU TEs had 5 receptions for 20 or more yards in the 4th quarter last season– T-3rd-most among FBS Teams

LSU’s offense threw for 20 or more yards on just 7.0% of 443 attempts last season — T-9th-worst among FBS offenses. Ole Miss’s defense allowed 20+ yards on just 7.9% of attempts last season — T-3rd-best among SEC defenses.

LSU Skill Players were targeted 10 times in the Red Zone last week– most among SEC Teams

Ole Miss Offensive Stats & Trends

Ole Miss averaged 20.2 yards per completion (1,053 yards/52 completions) in the 4th quarter last season– best among FBS Offenses; Average: 11.7

Ole Miss Skill Players averaged 20.2 yards per reception (1,053 yards/52 catches) in the 4th quarter last season– best among Power Conference Teams; Average: 11.9

Ole Miss averaged 20.2 yards per reception (1,053 yards/52 catches) in the 4th quarter last season– best among FBS Offenses; Average: 11.7

Ole Miss Skill Players had 22 receptions for 20 or more yards in the 4th quarter last season– most among SEC Teams

Ole Miss Skill Players averaged 20.2 yards per reception (1,053 yards/52 catches) in the 4th quarter last season– best among FBS Teams; Average: 11.8

LSU Defensive Stats & Trends

LSU sacked opposing QBs on 29% of pass attempts (7/24) last week– 2nd-best among Power Conference Teams; Average: 8%

LSU allowed a Completion Pct of just 31% (8 completions/26 attempts) in the Red Zone last season– best in FBS; Average: 54%

LSU tackled opponents for a loss on 12 of 31 rushing attempts (39% TFL%) last week– 2nd-best in FBS; Average: 16%.

LSU sacked opposing QBs on 29% of pass attempts (7/24) last week– best in the SEC; Average: 10%

LSU sacked opposing QBs on 29% of pass attempts (7/24) last week– 2nd-best in FBS; Average: 7%

Ole Miss Defensive Stats & Trends

Ole Miss allowed 7 rushing TDs on 456 carries (65.1 Carries Per TD) last season– 2nd-best among Power Conference Teams; Average: 25.5

Ole Miss tackled opponents for a loss on 112 of 456 rushing attempts (25% TFL%) last season– best in FBS; Average: 16%.

Ole Miss allowed 7 rushing TDs on 456 carries (65.1 Carries Per TD) last season– 2nd-best in FBS; Average: 23.2

Ole Miss tackled opponents for a loss on 112 of 456 rushing attempts (25% TFL%) last season– best among Power Conference Teams; Average: 16%.

Ole Miss allowed opponents to rush for 20+ yards on 2 of their 33 carries (6%) last week– worst in the SEC; Average: 1%


Bet now on Ole Miss Rebels vs LSU Tigers and all games with BetMGM


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

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