Northwestern vs Indiana Prediction, Odds & Best Prop Bets – NCAAF, Week 4

Indiana head coach Curt Cignetti watches from the sideline as his team plays Michigan during the first half of an NCAA college football game in Bloomington, Ind., Saturday, Nov. 9, 2024.
(AP Photo/AJ Mast)
Sportsbook Promos This Week
  • The Indiana Hoosiers are a -21 point favorite vs. the Northwestern Wildcats
  • Northwestern vs. Indiana Total (Over/Under): 49.5 points
  • TV Channel: FOX

Northwestern (2-0) visit Memorial Stadium (Bloomington, IN) to take on Indiana (3-0) on Sep. 25 in Bloomington, IN. Kickoff is scheduled for 8:00 pm.

The Indiana Hoosiers are betting favorites in Week 4, with the spread sitting at -21 (-108).

The Northwestern vs. Indiana Over/Under is 49.5 total points.

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Northwestern vs. Indiana Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Northwestern+21 -11049.5 -110+1050
Indiana -21 -10849.5 -108-1600

Northwestern vs Indiana Prediction:

The winning team model predicts Indiana will win this game with 89.0% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Northwestern Wildcats and the Indiana Hoosiers, key player performances this season and recent team trends.

Northwestern vs Indiana Spread Prediction:

Based on recent against-the-spread trends, the model predicts Indiana will cover the spread with 69.4% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Indiana Hoosiers vs Northwestern Wildcats and all games with BetMGM


  • Indiana has hit the Moneyline in their last 12 games (+13.75 Units / 7% ROI)
  • Indiana has hit the 1H Moneyline in 12 of their last 14 games (+11.80 Units / 1% ROI)
  • Indiana has hit the 1Q Moneyline in 11 of their last 14 games (+10.50 Units / 2% ROI)
  • Indiana has hit the 1H Game Total Under in 10 of their last 15 games (+4.10 Units / 24% ROI)
  • Indiana have covered the 1H Spread in 9 of their last 15 games (+2.15 Units / 13% ROI)
  • Northwestern has hit the Moneyline in 8 of their last 12 games (+11.50 Units / 43% ROI)
  • Northwestern has hit the 1Q Moneyline in 7 of their last 12 games (+8.90 Units / 45% ROI)
  • Northwestern have covered the 1Q Spread in 9 of their last 12 games (+6.00 Units / 47% ROI)
  • Northwestern have covered the 1H Spread in 9 of their last 12 games (+5.45 Units / 39% ROI)
  • Northwestern have covered the Spread in 7 of their last 12 games (+3.70 Units / 28% ROI)

Northwestern Against the Spread (ATS) Record

Northwestern Wildcats is 2-0 against the spread this college football season (+2 Units / 90.91% ROI).

  • Northwestern is 2-0 when betting on the Moneyline for +2 Units / 28.37% ROI
  • Northwestern is 1-0 when betting the Over for +1 Units / 45.45% ROI
  • Northwestern is 0-1 when betting the Under for -1.1 Units / -50% ROI

Indiana Against the Spread (ATS) Record

Indiana Hoosiers is 0-3 against the spread this college football season (-3.3 Units / -100% ROI).

  • Indiana is 0-0 when betting on the Moneyline for +0 Units / 0% ROI
  • Indiana is 1-2 when betting the Over for -1.2 Units / -36.36% ROI
  • Indiana is 2-1 when betting the Under for +0.9 Units / 27.27% ROI

Northwestern: Keys to the Game vs. Indiana

Northwestern was winless (0-7) when allowing 100 or more rushing yards last season– T-worst in FBS; Average: .422

Northwestern was winless (0-6) when allowing more than 3 explosive runs last season– T-worst in FBS; Average: .414

Northwestern was 1-8 (.111) when allowing 10 or more rushes of four or more yards last season– T-5th-worst in FBS; Average: .479

Northwestern was 1-8 (.111) when allowing 10 or more rushes of four or more yards last season– T-2nd-worst among Power Conference Teams; Average: .515

Indiana: Keys to the Game vs. Northwestern

Indiana is undefeated (14-0) when allowing less than 5 yards per rush this season– T-best in FBS; Average: .615

Indiana is undefeated (6-0) when the opposing team rushes more than 30 times this season– best among Power Conference Teams; Average: .470

Indiana is undefeated (16-0) when rushing at least 4 yards in a play 10 or more times this season– T-best in FBS; Average: .585

Indiana is undefeated (14-0) when allowing less than 50% of third down conversion opportunities this season– T-best in FBS; Average: .603

Matchup Notes for Northwestern vs. Indiana

Indiana’s offense threw for 20 or more yards on 13.9% of 404 attempts last season — 10th-best among FBS offenses. Northwestern’s defense allowed 20+ yards on 10.5% of attempts last season — 3rd-worst among Big Ten defenses.

Indiana’s TEs had 39 receptions in 16 games (just 2.4 per game) last season — 2nd-worst among Big Ten TEs. Northwestern’s defense allowed just 17.2 receptions per game last season — T-33rd-best among FBS defenses.

Indiana gained 3,820 yards on 291 receptions (13.1 YPR) last season — 3rd-best among Big Ten skill players. Northwestern’s defense allowed 11.3 Yards Per Reception last season — 4th-worst among Big Ten defenses.

Northwestern’s TEs gained 392 yards on 42 receptions (just 9.3 YPR) last season — 5th-worst among Big Ten TEs. Indiana’s defense allowed just 10.0 Yards Per Reception last season — T-3rd-best among P5 defenses.

Northwestern’s offense threw for 2,417 passing yards in 13 games (just 185.9 YPG) last season — 30th-worst among FBS offenses. Indiana’s defense allowed just 188.8 passing yards per game last season — T-24th-best among FBS defenses.

Northwestern’s offense threw for 20 or more yards on just 8.5% of 378 attempts last season — T-32nd-worst among FBS offenses. Indiana’s defense allowed 20+ yards on just 8.4% of attempts last season — T-34th-best among FBS defenses.

Northwestern Offensive Stats & Trends

Northwestern Skill Players averaged a touchdown every 30.0 receptions (210 Rec/7 TDs) last season– worst Receptions Per TD among Big Ten Teams; Average: 12.7

Northwestern Skill Players averaged a touchdown every 30.0 receptions (210 Rec/7 TDs) last season– 2nd-worst Receptions Per TD among FBS Teams; Average: 11.7

Northwestern WRs averaged a touchdown every 32.0 receptions (128 Rec/4 TDs) last season– worst Receptions Per TD among Power Conference Teams; Average: 10.9

Northwestern WRs averaged a touchdown every 32.0 receptions (128 Rec/4 TDs) last season– worst Receptions Per TD among Big Ten Teams; Average: 10.7

Northwestern Skill Players averaged a touchdown every 30.0 receptions (210 Rec/7 TDs) last season– 2nd-worst Receptions Per TD among Power Conference Teams; Average: 11.7

Indiana Offensive Stats & Trends

Indiana have thrown for 15 TDs in the 3rd quarter this season– most among FBS Offenses

Indiana WRs have caught 27 touchdown passes in the Red Zone this season– most among Big Ten Teams

Indiana have thrown for 29 TDs in the Red Zone this season– most among FBS Offenses

Indiana WRs have caught 42 touchdown passes this season– most among Power Conference Teams

Indiana Skill Players have caught 29 touchdown passes in the Red Zone this season– most among Big Ten Teams

Northwestern Defensive Stats & Trends

Northwestern had no interceptions (0 pass attempts) in the Red Zone last season– T-worst in FBS; Average: 36.5

Northwestern had no interceptions (0 pass attempts) in the Red Zone last season– T-worst in the Big Ten; Average: 38.1

Northwestern tackled opponents for a loss on just 2 of 34 rushing attempts (6% TFL%) on 3rd and short last season– T-28th-worst in FBS; Average: 10%.

Northwestern tackled opponents for a loss on just 6 of 67 rushing attempts (9% TFL%) in the Red Zone last season– 17th-worst in FBS; Average: 15%.

Northwestern allowed a Completion Pct of just 40% (16 completions/40 attempts) on 3rd and long last season– best in the Big Ten; Average: 53%

Indiana Defensive Stats & Trends

Indiana has tackled opponents for a loss on 107 of 413 rushing attempts (26% TFL%) this season– 2nd-best in FBS; Average: 15%.

Indiana has tackled opponents for a loss on 107 of 413 rushing attempts (26% TFL%) this season– best in the Big Ten; Average: 16%.

Indiana tackled opponents for a loss on 107 of 413 rushing attempts (26% TFL%) last season– best in the Big Ten; Average: 16%.

Indiana tackled opponents for a loss on 107 of 413 rushing attempts (26% TFL%) last season– 2nd-best among Power Conference Teams; Average: 16%.

Indiana opponents has averaged 48.6 Passing Attempts per TD (486 Pass Attempts/10 Passing TDs) this season– 2nd-best among Power Conference Teams; Average: 22.7


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