Ohio vs South Alabama Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 3

South Alabama head coach Major Applewhite reacts during an NCAA football game against Coastal Carolina on Saturday, Sept. 20, 2025, in Mobile, Ala.
(AP Photo/Matthew Hinton)
Sportsbook Promos This Week
  • The South Alabama Jaguars are a -7 point favorite vs. the Ohio Bobcats
  • Ohio vs. South Alabama Total (Over/Under): 50.5 points
  • TV Channel: ESPN+

Ohio (1-1) visit Hancock Whitney Stadium to take on South Alabama (1-1) on Sep. 19 in Mobile, AL. Kickoff is scheduled for 7:00 pm.

The South Alabama Jaguars are betting favorites in Week 3, with the spread sitting at -7 (-108).

The Ohio vs. South Alabama Over/Under is 50.5 total points.

Bet now on South Alabama Jaguars vs Ohio Bobcats & all NCAAF games with BetMGM

Ohio vs. South Alabama Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Ohio+7 -11050.5 -112+220
South Alabama -7 -10850.5 -105-275

Ohio vs South Alabama Prediction:

The winning team model predicts South Alabama will win this game with 56.0% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Ohio Bobcats and the South Alabama Jaguars, key player performances this season and recent team trends.

Ohio vs South Alabama Spread Prediction:

Based on recent against-the-spread trends, the model predicts South Alabama will cover the spread with 54.0% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on South Alabama Jaguars vs Ohio Bobcats and all games with BetMGM


  • Ohio has hit the 1Q Moneyline in 4 of their last 5 away games (+5.20 Units / 58% ROI)
  • Ohio has hit the 1H Moneyline in 8 of their last 12 games (+3.10 Units / 1% ROI)
  • Ohio have covered the 1Q Spread in 4 of their last 5 away games (+2.85 Units / 46% ROI)
  • Ohio have covered the 1H Spread in 4 of their last 5 away games (+2.80 Units / 49% ROI)
  • Ohio has hit the Moneyline in 9 of their last 12 games (+2.25 Units / 2% ROI)
  • South Alabama has hit the 1Q Game Total Under in 4 of their last 5 games at home (+2.85 Units / 47% ROI)
  • South Alabama have covered the 1Q Spread in 7 of their last 11 games (+2.75 Units / 22% ROI)
  • South Alabama has hit the Game Total Over in 7 of their last 11 games (+2.60 Units / 21% ROI)
  • South Alabama has hit the 1H Game Total Under in 7 of their last 11 games (+2.40 Units / 19% ROI)
  • South Alabama has hit the 1H Moneyline in 4 of their last 5 games at home (+2.30 Units / 16% ROI)

Ohio Against the Spread (ATS) Record

Ohio Bobcats is 1-1 against the spread this college football season (-0.1 Units / -4.55% ROI).

  • Ohio is 1-1 when betting on the Moneyline for +0 Units / 0% ROI
  • Ohio is 2-0 when betting the Over for +2 Units / 90.91% ROI
  • Ohio is 0-2 when betting the Under for -2.2 Units / -100% ROI

South Alabama Against the Spread (ATS) Record

South Alabama Jaguars is 2-0 against the spread this college football season (+2 Units / 90.91% ROI).

  • South Alabama is 1-1 when betting on the Moneyline for +0 Units / 0% ROI
  • South Alabama is 1-1 when betting the Over for -0.1 Units / -4.55% ROI
  • South Alabama is 1-1 when betting the Under for -0.1 Units / -4.55% ROI

Ohio: Keys to the Game vs. South Alabama

Ohio was 7-1 (.875) when intercepting at least 1 pass last season– T-18th-best in FBS; Average: .668

Ohio was 6-3 (.667) when their opponent rushed more than 30 times last season– T-24th-best in FBS; Average: .442

Ohio was 4-3 (.571) when sacking the QB less than 3 times last season– T-14th-best among Non-Power Conference Teams; Average: .388

Ohio was 9-1 (.900) when allowing less than 50% of third down conversion opportunities last season– T-7th-best in FBS; Average: .602

South Alabama: Keys to the Game vs. Ohio

South Alabama was 7-2 (.778) when intercepting at least 1 pass last season– T-37th-best in FBS; Average: .668

South Alabama was 2-6 (.250) when allowing 200 or more passing yards last season– T-16th-worst in FBS; Average: .481

South Alabama was 2-5 (.286) when the opposing team converts 55% or more of its red zone chances into touchdowns last season– T-37th-worst in FBS; Average: .418

South Alabama was 6-1 (.857) when allowing less than 5 explosive passes in the 2023 season– T-4th-best among Non-Power Conference Teams; Average: .543

Matchup Notes for Ohio vs. South Alabama

South Alabama has averaged just 10.3 yards after the catch since the 2024 season — T-18th-worst among FBS skill players. Ohio’s defense has allowed 12.1 RAC since the 2024 season — T-30th-worst among FBS defenses.

South Alabama’s WRs has averaged just 11.7 yards after the catch since the 2024 season — T-27th-worst among FBS WRs. Ohio’s defense has allowed 13.7 RAC to WRs since the 2024 season — T-22nd-worst among FBS defenses.

South Alabama’s WRs has averaged just 11.7 yards after the catch since the 2024 season — T-27th-worst among FBS WRs. Ohio’s defense has allowed 12.1 RAC since the 2024 season — T-30th-worst among FBS defenses.

Ohio’s WRs has 155 receptions in 15 games (just 10.3 per game) since the 2024 season — T-31st-worst among FBS WRs. South Alabama’s defense has allowed just 16.6 receptions per game since the 2024 season — 25th-best among FBS defenses.

Ohio had 191 receptions in 13 games (just 14.7 per game) last season — 24th-worst among FBS skill players. South Alabama’s defense allowed just 17.2 receptions per game last season — T-33rd-best among FBS defenses.

Ohio’s RBs had 18 receptions in 13 games (just 1.4 per game) last season — T-9th-worst among FBS RBs. South Alabama’s defense allowed just 17.2 receptions per game last season — T-33rd-best among FBS defenses.

Ohio Offensive Stats & Trends

Ohio QBs rushed for 262 yards in close and late situations last season– most among FBS Teams

Ohio QBs rushed for 17 TDs in the Red Zone last season– T-2nd-most among FBS Teams

Ohio QBs rushed for 19 TDs last season– T-4th-most among FBS Teams

Ohio QBs rushed for 5 TDs in the 4th quarter last season– T-3rd-most among FBS Teams

Ohio’s WRs has 155 receptions in 15 games (just 10.3 per game) since the 2024 season — T-31st-worst among FBS WRs. South Alabama’s defense has allowed just 16.6 receptions per game since the 2024 season — 25th-best among FBS defenses.

South Alabama Offensive Stats & Trends

South Alabama WRs averaged 21.7 yards per reception (607 yards/28 catches) in the 4th quarter in the 2023 season– T-2nd-best among FBS Teams; Average: 13.5

South Alabama has averaged just 10.3 yards after the catch since the 2024 season — T-18th-worst among FBS skill players. Ohio’s defense has allowed 12.1 RAC since the 2024 season — T-30th-worst among FBS defenses.

South Alabama RBs averaged 6.2 Yards per Carry (1,919 yards/308 carries) last season– 9th-best among FBS Teams; Average: 5.1

South Alabama averaged just 9.7 yards per completion (458 yards/47 completions) on 3rd down last season– T-18th-worst among FBS Offenses; Average: 11.8

South Alabama RBs averaged 6.9 yards from scrimmage per touch (1,256 yards / 181 touches) on 1st down last season– T-6th-best among FBS Teams; Average: 5.4

Ohio Defensive Stats & Trends

Ohio tackled opponents for a loss on 93 of 364 rushing attempts (26% TFL%) in the 2023 season– best among Non-Power Conference Teams; Average: 16%.

Ohio tackled opponents for a loss on 93 of 364 rushing attempts (26% TFL%) in the 2023 season– 2nd-best in FBS; Average: 16%.

Ohio allowed passes of 40+ yards on 14 of 359 attempts (4%) last season– 6th-worst in FBS; Average: 2%

Ohio allowed 13 TDs in close and late situations last season– T-2nd-most in FBS

Ohio tackled opponents for a loss on 7 of 30 rushing attempts (23% TFL%) on 3rd and short last season– 6th-best in FBS; Average: 11%.

South Alabama Defensive Stats & Trends

South Alabama did not record a sack (52 pass attempts) in the Red Zone last season– T-worst among Non-Power Conference Teams; Average: 14.6

South Alabama did not record a sack (52 pass attempts) in the Red Zone last season– T-worst in FBS; Average: 15.0

South Alabama opponents averaged 8.7 Passing Attempts per TD (52 Pass Attempts/6 Passing TDs) in the Red Zone last season– best among Non-Power Conference Teams; Average: 3.8

South Alabama opponents averaged 8.7 Passing Attempts per TD (52 Pass Attempts/6 Passing TDs) in the Red Zone last season– 2nd-best in FBS; Average: 3.9

South Alabama allowed 4.9 yards from scrimmage per touch (410 yards / 84 touches) in the Red Zone last season– 4th-worst in FBS; Average: 3.7


Bet now on South Alabama Jaguars vs Ohio Bobcats and all games with BetMGM


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