Ohio State vs Indiana Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 7

Indiana head coach Curt Cignetti watches from the sideline as his team plays Michigan during the first half of an NCAA college football game in Bloomington, Ind., Saturday, Nov. 9, 2024.
(AP Photo/AJ Mast)
Odds Boost This Weekend
  • The Ohio State Buckeyes are a -4 point favorite vs. the Indiana Hoosiers
  • Ohio State vs. Indiana Total (Over/Under): 50.5 points
  • TV Channel: FOX

Ohio State (5-1) visit Memorial Stadium (Bloomington, IN) to take on Indiana (6-0) on Oct. 17 in Bloomington, IN. Kickoff is scheduled for 12:00 pm.

The Ohio State Buckeyes are betting favorites in Week 7, with the spread sitting at -4 (-105).

The Ohio State vs. Indiana Over/Under is 50.5 total points.

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Ohio State vs. Indiana Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Ohio State-4 -10550.5 -108-175
Indiana +4 -12550.5 -110+145

Ohio State vs Indiana Prediction:

The winning team model predicts Ohio State will win this game with 54.4% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Ohio State Buckeyes and the Indiana Hoosiers, key player performances this season and recent team trends.

Ohio State vs Indiana Spread Prediction:

Based on recent against-the-spread trends, the model predicts Ohio State will cover the spread with 52.9% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Indiana has hit the Moneyline in their last 13 games (+13.55 Units / 6% ROI)
  • Indiana has hit the 1H Moneyline in 13 of their last 15 games (+9.30 Units / 1% ROI)
  • Indiana has hit the 1Q Moneyline in 11 of their last 15 games (+7.80 Units / 1% ROI)
  • Indiana has hit the 1H Game Total Under in 11 of their last 16 games (+5.10 Units / 27% ROI)
  • Indiana has hit the 1Q Game Total Under in 10 of their last 16 games (+4.05 Units / 21% ROI)
  • Ohio State has hit the 1H Moneyline in 11 of their last 12 games (+8.05 Units / 2% ROI)
  • Ohio State have covered the 1Q Spread in 10 of their last 14 games (+5.60 Units / 33% ROI)
  • Ohio State have covered the 1H Spread in 10 of their last 14 games (+5.35 Units / 33% ROI)
  • Ohio State has hit the Game Total Under in their last 5 away games (+5.00 Units / 91% ROI)
  • Ohio State has hit the Team Total Over in 9 of their last 14 games (+3.55 Units / 22% ROI)

Ohio State Against the Spread (ATS) Record

Ohio State Buckeyes is 4-2 against the spread this college football season (+1.8 Units / 27.27% ROI).

  • Ohio State is 2-1 when betting on the Moneyline for +1 Units / 2.08% ROI
  • Ohio State is 4-2 when betting the Over for +1.78 Units / 27.09% ROI
  • Ohio State is 2-4 when betting the Under for -2.45 Units / -36.95% ROI

Indiana Against the Spread (ATS) Record

Indiana Hoosiers is 1-5 against the spread this college football season (-4.5 Units / -68.18% ROI).

  • Indiana is 3-0 when betting on the Moneyline for +3 Units / 7.04% ROI
  • Indiana is 3-3 when betting the Over for -0.28 Units / -4.26% ROI
  • Indiana is 3-3 when betting the Under for -0.3 Units / -4.53% ROI

Ohio State: Keys to the Game vs. Indiana

Ohio State is undefeated (15-0) when allowing less than 50% of third down conversion opportunities since the 2024 season– T-best in FBS; Average: .618

Ohio State was 14-1 (.933) when allowing less than 5 yards per rush last season– 3rd-best among Power Conference Teams; Average: .647

Ohio State was 14-1 (.933) when converting 55% or more of its red zone chances into touchdowns last season– best among Power Conference Teams; Average: .657

Ohio State was 14-1 (.933) when converting 55% or more of its red zone chances into touchdowns last season– best in FBS; Average: .624

Indiana: Keys to the Game vs. Ohio State

Indiana is undefeated (10-0) when sacking the QB less than 3 times since the 2024 season– best among Power Conference Teams; Average: .490

Indiana is undefeated (17-0) when averaging more than 5 yards on first down plays since the 2024 season– T-best in FBS; Average: .624

Indiana is undefeated (10-0) when sacking the QB less than 3 times since the 2024 season– best in FBS; Average: .436

Indiana was winless (0-7) when their opponent committed less than 60 yards in penalties in the 2023 season– worst among Power Conference Teams; Average: .576

Matchup Notes for Ohio State vs. Indiana

Indiana’s offense threw for 20 or more yards on 13.9% of 404 attempts last season — 10th-best among FBS offenses. Ohio State’s defense allowed 20+ yards on just 5.3% of attempts last season — best among P5 defenses.

Indiana’s offense threw for 20 or more yards on 13.9% of 404 attempts last season — 10th-best among FBS offenses. Ohio State’s defense allowed 20+ yards on just 5.3% of attempts last season — T-2nd-best among FBS defenses.

Indiana’s offense threw for 20 or more yards on 13.9% of 404 attempts last season — 10th-best among FBS offenses. Ohio State’s defense allowed 20+ yards on just 5.3% of attempts last season — best among Big Ten defenses.

Ohio State’s WRs has averaged 14.7 yards after the catch since the 2024 season — T-10th-best among FBS WRs. Indiana’s defense has allowed just 11.4 RAC to WRs since the 2024 season — 9th-best among FBS defenses.

Ohio State’s WRs has 518 receptions in 36 games (14.4 per game) since the 2024 season — T-30th-best among FBS WRs. Indiana’s defense has allowed just 10.9 receptions per game to WRs since the 2024 season — T-27th-best among FBS defenses.

Ohio State’s QBs threw for 3,749 passing yards in 14 games (267.8 YPG) last season — 24th-best among FBS teams. Indiana’s defense allowed just 188.8 passing yards per game last season — T-24th-best among FBS defenses.

Ohio State Offensive Stats & Trends

Ohio State completed passes for 40+ yards on 3 of their 21 total passing attempts (14%) last week– T-best among FBS Offenses; Average: 2%

Ohio State have averaged 19.8 yards per reception (397 yards/20 catches) in the 4th quarter this season– T-4th-best among FBS Offenses; Average: 11.8

Ohio State Skill Players have averaged 19.8 yards per reception (397 yards/20 catches) in the 4th quarter this season– T-4th-best among FBS Teams; Average: 11.8

Ohio State threw for 4 TDs last week– T-3rd-most among FBS Offenses

Ohio State have averaged 19.8 yards per completion (397 yards/20 completions) in the 4th quarter this season– T-4th-best among FBS Offenses; Average: 11.8

Indiana Offensive Stats & Trends

Indiana completed passes for 40+ yards on 3 of their 22 total passing attempts (14%) last week– 3rd-best among FBS Offenses; Average: 2%

Indiana have thrown for 21 TDs in the 3rd quarter since the 2024 season– most among FBS Offenses

Indiana have thrown 19 TDs and no interceptions this season– T-best among FBS Offenses; Average: 2.6

Indiana WRs have caught 61 touchdown passes since the 2024 season– most among Power Conference Teams

Indiana have thrown for 65 TDs since the 2024 season– most among FBS Offenses

Ohio State Defensive Stats & Trends

Ohio State opponents has averaged 94.5 Passing Attempts per TD (189 Pass Attempts/2 Passing TDs) this season– best in the Big Ten; Average: 21.8

Ohio State opponents has averaged 94.5 Passing Attempts per TD (189 Pass Attempts/2 Passing TDs) this season– best among Power Conference Teams; Average: 23.4

Ohio State has allowed 136.0 Passing Yards per game (2,720/20) since the 2024 season– best in FBS; Average: 214.8

Ohio State’s opponents attempted two-point conversions on 28% of PATs last season– highest in FBS; Average: 8%

Ohio State opponents has averaged 59.0 Passing Attempts per TD (531 Pass Attempts/9 Passing TDs) since the 2024 season– best in FBS; Average: 21.3

Indiana Defensive Stats & Trends

Indiana has tackled opponents for a loss on 148 of 608 rushing attempts (24% TFL%) since the 2024 season– best in the Big Ten; Average: 15%.

Indiana allowed no passing TDs (43 pass attempts) last week– T-best in the Big Ten; Average: 18.3

Indiana opponents has averaged 50.7 Passing Attempts per TD (659 Pass Attempts/13 Passing TDs) since the 2024 season– 2nd-best in FBS; Average: 21.3

Indiana opponents has averaged 50.7 Passing Attempts per TD (659 Pass Attempts/13 Passing TDs) since the 2024 season– 2nd-best among Power Conference Teams; Average: 22.9

Indiana tackled opponents for a loss on 107 of 413 rushing attempts (26% TFL%) last season– 2nd-best in FBS; Average: 15%.


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