Indiana vs. Nebraska Odds: Week 6 NCAA Football Betting

Nebraska quarterback Anthony Colandrea (10) escapes a tackle by Maryland's Carlton Smith (32) during the second half of an NCAA college football game Saturday, Oct. 3, 2026, in Lincoln, Neb.
(AP Photo/Rebecca S. Gratz)
Odds Boost This Weekend

Indiana’s toughest test of the year – so far, anyway – will arrive on Saturday in Lincoln. The Hoosiers draw still-undefeated Nebraska in a major lookahead spot, with Ohio State and Michigan both on deck. 

BetMGM has NCAA football odds available for all the Week 6 college football action. 

Indiana vs. Nebraska Odds

  • Point Spread: Indiana -7
  • Moneyline: Indiana -295  |  Nebraska +240
  • Total: 52.5

Indiana vs. Nebraska: Preview & Notes

Indiana has been a double-digit favorite in every regular-season game since last year’s road contest at Oregon. The Hoosiers are 28-1 in regular-season games under third-year head coach Curt Cignetti.

Both those stats are pertinent this weekend when Indiana plays a second Big Ten road game in as many weeks. 

Indiana will look to run the ball and control the game pace. The Hoosiers rank seventh nationally in EPA/rush, and Nebraska’s run defense offers only average resistance by FBS standards.

But Nebraska has an edge here too, since it generates 0.34 EPA/pass. Indiana’s back end ranks 86th nationally in EPA/pass allowed and 49th in defensive success rate on passing plays. Nebraska should find success throwing the ball.

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.