Louisville opens the 2026 football season against Ole Miss in Nashville. The Cardinals went 9-4 last year, including 4-4 in the ACC.
Current 2026 Win Total Odds
Louisville’s win total for 2026 is 7.5.
The Cardinals have won at least eight games the past four seasons. The last time they failed to win eight games was 2021 (6-7).
2026 Louisville Cardinals Football Schedule
Louisville’s non-conference schedule begins in Week 1 with a game vs. Ole Miss. The Cardinals home opener is Sept. 11, a non-conference game against Villanova.
Louisville’s first conference game is a Sept. 19 home matchup vs. SMU.
Non-Conference Matchups
- Sept. 6: vs. Ole Miss*
- Sept. 11: vs. Villanova
- Nov. 28: at Kentucky
Of Louisville’s non-conference opponents, Ole Miss won the most games in 2025; the Rebels went 13-2.
ACC Matchups
- Sept. 19: vs. SMU
- Sept. 26: vs. Wake Forest
- Oct. 3: at NC State
- Oct. 9: vs. Florida State
- Oct. 17: at Syracuse
- Oct. 31: vs. Stanford
- Nov. 7: at Georgia Tech
- Nov. 14: at North Carolina
- Nov. 21: vs. Pitt
Of Louisville’s conference opponents, SMU, Wake Forest, and Georgia Tech won the most games (9).
2025 Louisville Football Results
Louisville went 8-4 during the 2025 regular season and then beat Toledo in the Bush’s Boca Raton Bowl of Beans to finish 9-4.
- Aug. 30: vs. Eastern Kentucky – Win (51-17)
- Sept. 6: vs. James Madison – Win (28-14)
- Sept. 20: vs. Bowling Green – Win (40-17)
- Sept. 27: at Pitt – Win (34-27)
- Oct. 4: vs. Virginia – Loss (30-27)(OT)
- Oct. 17: at Miami – Win (24-21)
- Oct. 25: vs. Boston College – Win (38-24)
- Nov. 1: at Virginia Tech – Win (28-16)
- Nov. 8: vs. California – Loss (29-26)(OT)
- Nov. 14: vs. Clemson – Loss (20-19)
- Nov. 22: at SMU – Loss (38-6)
- Nov. 29: vs. Kentucky – Win (41-0)
- Dec. 23: vs. Toledo* – Win (27-22)
*neutral site
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