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The Cardinals odds to win the ACC are +1200.
The Cardinals national championship odds are +35000.
The Cardinals odds to make the College Football Playoff are +1000.
Bet on Clemson, Miami, SMU, and other ACC football teams to win the 2025 ACC Championship. Read More
Clemson (4-5) visit L&N Federal Credit Union Stadium to take on Louisville (7-2) on Nov. 14 in Louisville, KY. Kickoff is scheduled for 7:30pm EST. Louisville is a betting favorite in Week 12, wit Read More
California (5-4) visit L&N Federal Credit Union Stadium to take on Louisville (7-1) on Nov. 8 in Louisville, KY. Kickoff is scheduled for 7:00pm EST. Louisville is a betting favorite in Week 11, w Read More
Louisville (6-1) visit Lane Stadium to take on Virginia Tech (3-5) on Nov. 1 in Blacksburg, VA. Kickoff is scheduled for 3:00pm EDT. Louisville is a betting favorite in Week 10, with the spread sittin Read More
Boston College (1-6) visit L&N Federal Credit Union Stadium to take on Louisville (5-1) on Oct. 25 in Louisville, KY. Kickoff is scheduled for 7:30pm EDT. Louisville is a betting favorite in Week Read More
Louisville (4-1) visit Hard Rock Stadium to take on Miami Florida (5-0) on Oct. 17 in Miami, FL. Kickoff is scheduled for 7:00pm EDT. Miami Florida is a betting favorite in Week 8, with the spread sit Read More
Virginia (4-1) visit L&N Federal Credit Union Stadium to take on Louisville (4-0) on Oct. 4 in Louisville, KY. Kickoff is scheduled for 3:30pm EDT. Louisville is a betting favorite in Week 6, with Read More
Louisville (3-0) visit Acrisure Stadium to take on Pittsburgh (2-1) on Sep. 27 in Pittsburgh, PA. Kickoff is scheduled for 12:00pm EDT. Louisville is a betting favorite in Week 5, with the spread sitt Read More
Bowling Green (2-1) visit L&N Federal Credit Union Stadium to take on Louisville (2-0) on Sep. 20 in Louisville, KY. Kickoff is scheduled for 12:00pm EDT. Louisville is a betting favorite in Week Read More
College football odds are available throughout year, including odds for all ACC teams:
Spreads, over/under totals, moneylines, and more odds are available for each Louisville football game this season.
Will the Cardinals make the College Football Playoff? Will they go over or under their regular-season win total? Will they win the national championship?
For example: If you bet $15 on Louisville (+10000) to make the playoff, the bet would settle when the Cardinals earn a playoff spot.
What’s the final scoring margin of the game?
For example: If you bet $30 on the Cardinals -13.5 (-115) against Stanford, Louisville must win the game by at least 14 points.
Alternatively, if you bet $40 on the Cardinals +7.5 (-110) against Miami (FL), Louisville must lose by seven points or less (or win the game).
Will Louisville win the game?
For example: If you bet $20 on the Cardinals -250 against Pittsburgh, Louisville must win the game (in regulation or overtime).
How many total points (by both teams) are scored in the game?
For example: If you bet $175 on over 59.5 (-105) in their game against NC State, the teams must combine for at least 60.
Alternatively, if you bet $125 on under 58.5 (-115), the teams must combine for 58 points or fewer.
If the combined point total is the same as the over/under total, the bet is a push.
At BetMGM, you may combine multiple bets — for college football or another sport — into parlays.
For example: If you bet $60 on a two-leg parlay with the Louisville football moneyline (-350) vs. Florida State and over 65.5 (-105) in the Duke-Syracuse game, both must hit for the bet to cash.
If one bet is a push, it’s eliminated from the parlay, and odds (and payout) are recalculated without that leg.
Read the latest betting tips and how-to guides from BetMGM experts.
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