Louisville vs. SMU Odds: Week 3 Showdown In the ACC

SMU wide receiver Romello Brinson gains yards after a catch during an NCAA college football game against Louisville Saturday, Nov. 22, 2025, in Dallas.
(AP Photo/Tony Gutierrez)
Sportsbook Promos This Week

Having already scored one major ACC road win this year, SMU will hunt for a second big conference win away from Dallas this Saturday. Another win would put the Mustangs on the inside track for another ACC Championship Game appearance.

BetMGM has NCAA football odds available for all the Week 3 college football action. 

Louisville vs. SMU Odds

  • Point Spread: Louisville -2
  • Moneyline: Louisville -120  |  SMU +100
  • Total: 59.5

Louisville vs. SMU: Preview & Notes

This year’s early trip to Louisville is reminiscent of the Mustangs’ early-season trip to Kentucky in 2024, when the Mustangs won 34-27 as a 7-point road underdog.

SMU has gained more market respect since then. It’s also never lost to Louisville, outscoring the Cardinals 72-33 across two games since joining the SEC.

SMU is 10-7 ATS in conference road games under head coach Rhett Lashlee. 

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About the Author Read More @chaseakiddy

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.

Chase Kiddy is a senior writer for BetMGM who primarily covers college sports. He takes two things very seriously: board games and Las Vegas picks contests. He has previously written for a number of print and online outlets, including the Richmond Times-Dispatch, Washington Post, Daily News-Record, and HERO Sports.