Having already scored one major ACC road win this year, SMU will hunt for a second big conference win away from Dallas this Saturday. Another win would put the Mustangs on the inside track for another ACC Championship Game appearance.
BetMGM has NCAA football odds available for all the Week 3 college football action.
Louisville vs. SMU Odds
- Point Spread: Louisville -2
- Moneyline: Louisville -120 | SMU +100
- Total: 59.5
Louisville vs. SMU: Preview & Notes
This year’s early trip to Louisville is reminiscent of the Mustangs’ early-season trip to Kentucky in 2024, when the Mustangs won 34-27 as a 7-point road underdog.
SMU has gained more market respect since then. It’s also never lost to Louisville, outscoring the Cardinals 72-33 across two games since joining the SEC.
SMU is 10-7 ATS in conference road games under head coach Rhett Lashlee.
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