Washington vs USC Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 5

Southern California head coach Lincoln Riley watches during the first half of an NCAA college football game against Utah, Saturday, Oct. 21, 2023, in Los Angeles. (AP Photo/Ryan Sun)
(AP Photo/Ryan Sun)
Odds Boost This Weekend
  • The USC Trojans are a -9.5 point favorite vs. the Washington Huskies
  • Washington vs. USC Total (Over/Under): 55.5 points
  • TV Channel: NBC | PEAC

Washington (3-1) visit Los Angeles Memorial Coliseum to take on USC (4-1) on Oct. 3 in Los Angeles, CA. Kickoff is scheduled for 7:30 pm.

The USC Trojans are betting favorites in Week 5, with the spread sitting at -9.5 (-112).

The Washington vs. USC Over/Under is 55.5 total points.

Bet now on USC Trojans vs Washington Huskies & all NCAAF games with BetMGM

Washington vs. USC Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Washington+9.5 -10555.5 +120+290
USC -9.5 -11255.5 -160-375

Washington vs USC Prediction:

The winning team model predicts USC will win this game with 68.1% confidence, based on game simulations, offensive & defensive matchups and recent game results.

The winning team prediction factors in up-to-date player injuries for both the Washington Huskies and the USC Trojans, key player performances this season and recent team trends.

Washington vs USC Spread Prediction:

Based on recent against-the-spread trends, the model predicts USC will cover the spread with 63.6% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


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  • Washington has hit the 1Q Game Total Under in 10 of their last 13 games (+6.00 Units / 39% ROI)
  • Washington has hit the 1H Game Total Under in 9 of their last 13 games (+4.40 Units / 30% ROI)
  • Washington has hit the Game Total Under in 8 of their last 13 games (+2.50 Units / 17% ROI)
  • Washington has hit the Team Total Under in 8 of their last 13 games (+2.30 Units / 16% ROI)
  • USC has hit the 1Q Game Total Under in 7 of their last 8 games at home (+6.05 Units / 70% ROI)
  • USC has hit the Moneyline in 6 of their last 7 games at home (+5.00 Units / 5% ROI)
  • USC has hit the 1Q Moneyline in 8 of their last 13 games (+2.95 Units / 4% ROI)
  • USC has hit the Game Total Over in 7 of their last 13 games (+0.40 Units / 3% ROI)
  • USC has hit the Team Total Under in 7 of their last 13 games (+0.20 Units / 1% ROI)

Washington Against the Spread (ATS) Record

Washington Huskies is 0-4 against the spread this college football season (-4.4 Units / -100% ROI).

  • Washington is 2-1 when betting on the Moneyline for -2.5 Units / -3.27% ROI
  • Washington is 2-2 when betting the Over for -0.2 Units / -4.55% ROI
  • Washington is 2-2 when betting the Under for -0.2 Units / -4.55% ROI

USC Against the Spread (ATS) Record

USC Trojans is 1-4 against the spread this college football season (-3.4 Units / -61.82% ROI).

  • USC is 3-1 when betting on the Moneyline for +2 Units / 2.15% ROI
  • USC is 4-1 when betting the Over for +2.9 Units / 52.73% ROI
  • USC is 1-4 when betting the Under for -3.4 Units / -61.82% ROI

Washington: Keys to the Game vs. USC

Washington was 11-1 (.917) when sacking the QB less than 3 times in the 2023 season– 3rd-best in FBS; Average: .420

Washington is 12-2 (.857) when averaging more than 5 yards on first down plays since the 2024 season– T-11th-best among Power Conference Teams; Average: .684

Washington is 10-1 (.909) when intercepting at least 1 pass since the 2024 season– T-16th-best in FBS; Average: .683

Washington was undefeated (8-0) when having a turnover margin within one of the opposing team in the 2023 season– T-best in FBS; Average: .533

USC: Keys to the Game vs. Washington

USC is 4-1 (.800) when in a one score game since the 2024 season– T-7th-best among Power Conference Teams; Average: .516

USC is 13-2 (.867) when averaging more than 5 yards on first down plays since the 2024 season– T-11th-best in FBS; Average: .626

USC is 9-2 (.818) when allowing less than 5 explosive passes since the 2024 season– T-23rd-best in FBS; Average: .628

USC is 7-5 (.583) when the opposing team rushes more than 30 times since the 2024 season– T-34th-best in FBS; Average: .449

Matchup Notes for Washington vs. USC

USC’s offense threw for 20 or more yards on 14.8% of 420 attempts last season — 6th-best among FBS offenses. Washington’s defense allowed 20+ yards on just 8.0% of attempts last season — T-26th-best among FBS defenses.

USC gained 3,825 yards on 275 receptions (13.9 YPR) last season — 10th-best among FBS skill players. Washington’s defense allowed just 10.2 Yards Per Reception last season — 4th-best among Big Ten defenses.

USC’s WRs gained 2,759 yards on 185 receptions (14.9 YPR) last season — 2nd-best among Big Ten WRs. Washington’s defense allowed just 10.2 Yards Per Reception last season — 4th-best among Big Ten defenses.

Washington gained 3,175 yards on 254 receptions (12.5 YPR) last season — 4th-best among Big Ten skill players. USC’s defense allowed just 10.4 Yards Per Reception last season — T-16th-best among FBS defenses.

Washington’s offense threw for 20 or more yards on 13.2% of 370 attempts last season — T-13th-best among FBS offenses. USC’s defense allowed 20+ yards on just 8.1% of attempts last season — T-29th-best among FBS defenses.

Washington’s WRs has 439 receptions in 30 games (14.6 per game) since the 2024 season — T-27th-best among FBS WRs. USC’s defense has allowed 20.8 receptions per game since the 2024 season — worst among Big Ten defenses.

Washington Offensive Stats & Trends

Washington WRs have 7 receptions for 20 or more yards in the 4th quarter this season– most among Big Ten Teams

Washington Skill Players have 8 receptions for 20 or more yards in the 4th quarter this season– most among FBS Teams

Washington Skill Players have 8 receptions for 20 or more yards in the 4th quarter this season– most among Big Ten Teams

Washington WRs have 7 receptions for 20 or more yards in the 4th quarter this season– most among Power Conference Teams

Washington has scored on 42% of their drives (17/40) in close and late situations since the 2024 season– best among FBS Offenses; Average: 23%

USC Offensive Stats & Trends

USC TEs had no touchdowns on 5 receptions in the Red Zone last season– T-worst Receptions Per TD among Power Conference Teams; Average: 2.0

USC TEs had no touchdowns on 33 receptions last season– worst Receptions Per TD among Power Conference Teams; Average: 10.3

USC WRs caught 9 touchdown passes in the 4th quarter last season– most among Big Ten Teams

USC WRs have 23 receptions for 20 or more yards this season– most among Big Ten Teams

USC TEs were targeted 7 times in the 4th quarter last week– 2nd-most among FBS Teams

Washington Defensive Stats & Trends

Washington has allowed a Completion Pct of just 31% (4 completions/13 attempts) when opponents had over 10 yards to go this season– best in the Big Ten; Average: 57%

Washington allowed 3,879 Passing Yards in the 2023 season– most in the Big Ten

Washington averaged a sack every 26.3 pass attempts (579 Pass Attempts/22 Sacks) in the 2023 season– worst in the Big Ten; Average: 13.3

Washington has allowed a Completion Pct of just 31% (4 completions/13 attempts) when opponents had over 10 yards to go this season– 2nd-best in FBS; Average: 60%

Washington sacked opposing QBs on just 4% of pass attempts (22/579) in the 2023 season– worst in the Big Ten; Average: 8%

USC Defensive Stats & Trends

USC has allowed 4 TD passes in close and late situations this season– T-most in FBS

USC has allowed 4 TD passes in close and late situations this season– most in the Big Ten

USC has allowed 90 completions this season– most in the Big Ten

USC did not record a sack (35 pass attempts) last week– T-worst among Power Conference Teams; Average: 12.9

USC has allowed opponents to catch 12 of 15 passes (80% Reception Pct) on 3rd and long this season– worst in the Big Ten; Average: 54%


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