• The Cubs are -145 favorites vs the Astros
• Astros vs Cubs Over / Under today: 7 Runs
• Astros / Cubs TV Channel: ATV

The Houston Astros (+118) visit Wrigley Field to take on the Chicago Cubs (-145) on May 22, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Astros are 20-31 against the spread (ATS), while the Cubs are 21-29 ATS.

Astros vs Cubs Starting Pitchers Today:

• Astros starting pitcher: Spencer Arrighetti 5-1, 1.52 ERA
• Cubs starting pitcher: Jameson Taillon 2-3, 4.95 ERA

Astros vs. Cubs Odds, Run Line, Over/Under & Moneyline

Astros vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Friday‘s MLB game with 56.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Cubs and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Friday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Yordan Alvarez has hit the RBIs Under in 21 of his last 25 games (+14.35 Units / 32% ROI)
• Yordan Alvarez has hit the Runs Under in 19 of his last 25 games (+12.70 Units / 45% ROI)
• Yordan Alvarez has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+12.50 Units / 43% ROI)
• Cam Smith has hit the Hits Under in 16 of his last 25 games (+10.55 Units / 42% ROI)
• Christian Walker has hit the Singles Under in 13 of his last 15 games (+9.85 Units / 41% ROI)

And here are some favorite MLB player prop bets for Cubs players for Friday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

• Ian Happ has hit the Walks Over in 18 of his last 25 games (+12.35 Units / 45% ROI)
• Ian Happ has hit the Hits Under in 16 of his last 25 games (+12.15 Units / 48% ROI)
• Seiya Suzuki has hit the Total Bases Over in 18 of his last 25 games at home (+11.70 Units / 38% ROI)
• Moises Ballesteros has hit the Singles Under in 13 of his last 15 games (+10.60 Units / 54% ROI)
• Michael Busch has hit the Runs Under in 19 of his last 25 games (+10.45 Units / 26% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Team Total Under in 18 of their last 22 games (+12.70 Units / 47% ROI)
• The Houston Astros have hit the Game Total Over in 28 of their last 50 games (+6.20 Units / 11% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 12 games (+5.55 Units / 37% ROI)
• The Houston Astros have hit the Moneyline in 5 of their last 10 away games (+0.95 Units / 9% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 3 of their last 6 games (+0.55 Units / 9% ROI)

Cubs Best Bets Today:

• The Chicago Cubs have hit the Moneyline in 15 of their last 18 games at home (+11.30 Units / 43% ROI)
• The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 31 of their last 50 games at home (+9.80 Units / 16% ROI)
• The Chicago Cubs have hit the Team Total Over in 30 of their last 50 games at home (+9.25 Units / 16% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 30 of their last 50 games at home (+7.00 Units / 9% ROI)
• The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 11 games (+6.60 Units / 47% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 20-31 against the Run Line (-16.2 Units / -24.38% ROI).

• 20-31 when betting on the Moneyline for -13 Units / -21.78% ROI
• 28-20 when betting on the total runs Over for +5.1 Units / 8.87% ROI
• 20-28 when betting on the total runs Under for -10.4 Units / -19% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 21-29 against the Run Line (-8.85 Units / -15.04% ROI).

• 29-21 when betting on the Moneyline for +3.25 Units / 4.77% ROI
• 28-21 when betting on the total runs Over for +5.4 Units / 9.85% ROI
• 21-28 when betting on the total runs Under for -9.75 Units / -17.6% ROI

Cubs vs Astros Home Run Prop Bets Today

Cubs vs Astros Total Hits Prop Bets Today

Cubs vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Cubs

The Astros are just 0-29 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .106.

The Astros are just 20-31 (.392) this season — tied for 3rd lowest in MLB; League Avg: .500.

The Astros are just 8-17 (.320) on the road this season — 4th lowest in MLB; League Avg: .472.

The Astros are 17-1 (.944) when leading entering the 7th inning this season — tied for 5th best in MLB; League Avg: .863.

Cubs Keys to the Game vs. the Astros

The Cubs are 22-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .863.

The Cubs are 23-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .894.

The Cubs are 8-1 (.889) when they’ve scored in the first inning this season — best in MLB; League Avg: .636.

The Cubs are 14-1 (.933) when they’ve had 10 or more hits this season — 3rd best in MLB; League Avg: .755.

Astros Hitting Stats & Trends

The Astros are batting .305 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.

Astros hitters have an OBP of .379 (227 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

The Astros are batting .267 on the road this season — 2nd best in MLB.

Astros hitters have struck out in just 19% of their PA’s against LHP this season — 5th best in MLB.

Cubs Hitting Stats & Trends

Cubs hitters have an OBP of .354 (609 PA’s) against LHP this season — 2nd best in MLB.

Cubs have an xwOBA of just .341 this season — lowest in MLB.

The Cubs are batting .260 against LHP this season — 4th best in MLB.

Cubs hitters have drawn walks in 14% of their PA’s when leading off an inning this season — best in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 12% of batters this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Astros pitchers have allowed three-ball counts to 24% of batters they faced (483/1,994 PA’s) this season — highest in MLB.

Astros pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Cubs Pitching Stats & Trends

Cubs pitchers have walked 8% of batters this season — 5th best in MLB.

Cubs pitchers have allowed 67 home runs this season — tied for 4th most in MLB.

Cubs pitchers have allowed an exit velocity of 95 MPH or greater 532 times this season — 4th most in MLB.

Opponents have a groundball batting average of just .209 against Cubs pitchers with runners on base this season — 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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