Astros vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, May 24

Chicago Cubs' Dansby Swanson waves to the crowd before batting against his former team the Atlanta Braves in the second inning of a baseball game, Tuesday, Sept. 26, 2023, in Atlanta.
(AP Photo/John Bazemore)
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  • The Cubs are -175 favorites vs the Astros
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The Houston Astros (+145) visit Wrigley Field to take on the Chicago Cubs (-175) on May 24, 2026. First pitch is scheduled for 2:20 pm in Chicago, IL.

This season, the Astros are 21-31 against the spread (ATS), while the Cubs are 21-30 ATS.

Astros vs Cubs Starting Pitchers Today:

  • Astros starting pitcher: Peter Lambert 2-4, 3.60 ERA
  • Cubs starting pitcher: Shota Imanaga 4-4, 3.38 ERA

Astros vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros+1.5 -155O 7 +100+145
Cubs -1.5 +125U 7 -120-175

Astros vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 57.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • player high – away 

And here are some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • player  high – home
  • The Houston Astros have hit the Team Total Under in 18 of their last 23 games (+11.25 Units / 39% ROI)
  • The Houston Astros have hit the Game Total Under in 9 of their last 13 games (+6.90 Units / 50% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 18 of their last 30 away games (+5.55 Units / 16% ROI)
  • The Houston Astros have hit the Moneyline in 6 of their last 11 away games (+2.20 Units / 20% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 4 of their last 7 games (+1.65 Units / 23% ROI)
  • The Chicago Cubs have hit the Moneyline in 15 of their last 19 games at home (+9.85 Units / 35% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 30 of their last 50 games at home (+7.80 Units / 13% ROI)
  • The Chicago Cubs have hit the Team Total Under in 10 of their last 12 games (+7.70 Units / 51% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 12 games (+7.60 Units / 50% ROI)
  • The Chicago Cubs have covered the Run Line in 19 of their last 35 games at home (+4.95 Units / 12% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 21-31 against the Run Line (-15.2 Units / -22.25% ROI).

  • 21-31 when betting on the Moneyline for -11.75 Units / -19.36% ROI
  • 28-21 when betting on the total runs Over for +4.1 Units / 7.01% ROI
  • 21-28 when betting on the total runs Under for -9.4 Units / -16.8% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 21-30 against the Run Line (-9.85 Units / -16.46% ROI).

  • 29-22 when betting on the Moneyline for +1.8 Units / 2.59% ROI
  • 28-22 when betting on the total runs Over for +4.4 Units / 7.89% ROI
  • 22-28 when betting on the total runs Under for -8.75 Units / -15.46% ROI

Cubs vs Astros Home Run Prop Bets Today

Yes
Christian Walker +390
Mike Busch +450
Seiya Suzuki +475
Ian Happ +500
Isaac Paredes +500

Cubs vs Astros Total Hits Prop Bets Today

Over Under
Jeremy Pena 0.5 -275 0.5 +195
Alex Bregman 0.5 -210 0.5 +155
Mike Busch 0.5 -200 0.5 +150
Seiya Suzuki 0.5 -200 0.5 +145
Isaac Paredes 0.5 -185 0.5 +135

Cubs vs Astros Strikeout Prop Bets Today

Over Under
Mike Busch 0.5 -225 0.5 +165
Michael Conforto 0.5 -210 0.5 +150
Pete Crow-Armstrong 0.5 -200 0.5 +150
Jake Meyers 0.5 -190 0.5 +140
Jeremy Pena 0.5 -165 0.5 +125

Astros Keys to the Game vs. the Cubs

The Astros are just 1-17 (.056) when allowing 10 or more hits this season — lowest in MLB; League Avg: .246.

The Astros are just 0-28 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Astros are just 4-19 (.174) when allowing 2 or more home runs this season — 4th lowest in MLB; League Avg: .296.

The Astros are just 0-27 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .138.

Cubs Keys to the Game vs. the Astros

The Cubs are 19-7 (.731) vs the bottom 10 runs allowed teams this season Today, they face the Astros (27th runs allowed).

The Cubs are 14-1 (.933) when they’ve had 10 or more hits this season — tied for 2nd best in MLB; League Avg: .754.

The Cubs are 22-0 (1.000) when leading entering the 7th inning this season — tied for best in MLB; League Avg: .862.

The Cubs are 18-10 (.643) at home this season — 3rd best in MLB; League Avg: .530.

The Astros are batting .264 on the road this season — tied for 2nd best in MLB.

Astros hitters have an OPS of .744 (1,049 PA’s) on the road this season — 5th best in MLB.

The Astros are batting .300 when facing the starting pitcher for the 3rd time in a game this season — 2nd best in MLB.

Astros hitters have an OPS of .756 (1,128 PA’s) with bases empty this season — 2nd best in MLB.

Cubs hitters have an OBP of .263 (1,059 PA’s) with two-strikes this season — tied for best in MLB.

Cubs hitters have an OBP of .377 (463 PA’s) when leading off an inning this season — best in MLB.

Cubs hitters have an OBP of .343 (1,086 PA’s) at home this season — 4th best in MLB.

Cubs hitters have drawn walks in 12% of their PA’s against RHP this season — tied for best in MLB.

Astros pitchers have walked 12% of batters this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — lowest in MLB.

Astros pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Astros pitchers have an ERA of 5.18 (464.1 IP) this season — highest in MLB.

Opponents have a groundball batting average of just .207 against Cubs pitchers with runners on base this season — best in MLB.

The Cubs pitchers have allowed an average Exit Velocity of 90.1 MPH this season (1,291 balls in play) — 2nd highest in MLB

Cubs pitchers have a strikeout rate of just 17% when facing the leadoff batter in the inning this season — 2nd lowest in MLB.

Cubs pitchers have allowed an average Exit Velocity of 90.1 MPH (1,291 batted balls) this season — 2nd highest in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.