• The Twins are -155 favorites vs the Astros
• Astros vs Twins Over / Under today: 8 Runs
• Astros / Twins TV Channel: TWTV | SCHN

The Houston Astros (+125) visit Target Field to take on the Minnesota Twins (-155) on May 20, 2026. First pitch is scheduled for 1:40 pm in Minneapolis, MN.

This season, the Astros are 20-30 against the spread (ATS), while the Twins are 26-23 ATS.

Astros vs Twins Starting Pitchers Today:

• Astros starting pitcher: Michael Burrows 2-5, 5.73 ERA
• Twins starting pitcher: Joe Ryan 2-3, 3.20 ERA

Astros vs. Twins Odds, Run Line, Over/Under & Moneyline

Astros vs Twins Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Wednesday‘s MLB game with 57.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs Twins and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Yordan Alvarez has hit the RBIs Under in 20 of his last 25 games (+11.30 Units / 25% ROI)
• Isaac Paredes has hit the Hits Over in 16 of his last 20 away games (+10.60 Units / 31% ROI)
• Yordan Alvarez has hit the Hits Runs and RBIs Under in 18 of his last 25 games (+10.50 Units / 36% ROI)
• Yordan Alvarez has hit the Runs Under in 18 of his last 25 games (+10.45 Units / 37% ROI)
• Christian Walker has hit the Singles Under in 13 of his last 15 games (+9.85 Units / 41% ROI)

And here are some favorite MLB player prop bets for Twins players for Wednesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Best Bets Today:

• Byron Buxton has hit the Home Runs Over in 6 of his last 10 games at home (+17.80 Units / 178% ROI)
• Josh Bell has hit the Walks Under in his last 15 games (+15.00 Units / 47% ROI)
• Victor Caratini has hit the Runs Under in 14 of his last 15 games (+12.00 Units / 38% ROI)
• Victor Caratini has hit the Hits Under in 11 of his last 15 games (+11.20 Units / 75% ROI)
• Victor Caratini has hit the Hits Runs and RBIs Under in 16 of his last 20 games (+11.10 Units / 40% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Team Total Under in 17 of their last 21 games (+11.70 Units / 45% ROI)
• The Houston Astros have hit the Game Total Over in 28 of their last 50 games (+6.20 Units / 11% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 29 of their last 50 away games (+5.95 Units / 10% ROI)
• The Houston Astros have hit the Moneyline in 5 of their last 9 away games (+1.95 Units / 21% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 3 of their last 5 games (+1.55 Units / 30% ROI)

Twins Best Bets Today:

• The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 19 of their last 25 games at home (+12.40 Units / 40% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 18 of their last 25 games at home (+11.00 Units / 37% ROI)
• The Minnesota Twins have hit the Game Total Over in 24 of their last 40 games (+9.45 Units / 21% ROI)
• The Minnesota Twins have hit the Team Total Over in 28 of their last 45 games (+8.80 Units / 17% ROI)
• The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 25 games at home (+8.35 Units / 28% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 20-30 against the Run Line (-14.45 Units / -22.33% ROI).

• 20-30 when betting on the Moneyline for -12 Units / -20.44% ROI
• 28-19 when betting on the total runs Over for +6.2 Units / 10.99% ROI
• 19-28 when betting on the total runs Under for -11.4 Units / -21.25% ROI

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 26-23 against the Run Line (-5.95 Units / -8.36% ROI).

• 22-27 when betting on the Moneyline for -3.75 Units / -7.2% ROI
• 27-18 when betting on the total runs Over for +6.95 Units / 12.81% ROI
• 18-27 when betting on the total runs Under for -11.65 Units / -21.76% ROI

Twins vs Astros Home Run Prop Bets Today

Twins vs Astros Total Hits Prop Bets Today

Twins vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the Twins

The Astros are just 1-17 (.056) when allowing 10 or more hits this season — lowest in MLB; League Avg: .248.

The Astros are just 0-26 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .134.

The Astros are just 20-30 (.400) this season — 3rd lowest in MLB; League Avg: .500.

The Astros are just 0-27 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .052.

Twins Keys to the Game vs. the Astros

The Twins are just 2-18 (.100) when allowing 5 or more runs this season — tied for 3rd lowest in MLB; League Avg: .209.

The Twins are just 19-4 (.826) when leading entering the 8th inning this season — tied for 5th lowest in MLB; League Avg: .896.

The Twins are just 0-20 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .104.

The Twins are just 9-12 (.429) vs the bottom 10 runs allowed teams this season Today, they face the Astros (28th runs allowed).

Astros Hitting Stats & Trends

The Astros are batting .272 on the road this season — 2nd best in MLB.

The Astros are batting .311 when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Astros hitters have an OBP of .386 (223 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

Astros hitters are slugging .409 this season — 5th best in MLB.

Twins Hitting Stats & Trends

Twins hitters have 26 extra-base hits out of 52 total hits (50%) on the first pitch of at-bats this season — best in MLB.

Twins hitters have a 55% QAB rate with runners in scoring position this season — best in MLB.

The Twins are batting just .280 on the first pitch of at-bats this season — 4th lowest in MLB.

The Twins are batting just .197 with two outs this season — 2nd lowest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 12% of batters this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Astros pitchers have a first-pitch strike rate of just 58% this season — 3rd lowest in MLB.

Astros pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

Twins Pitching Stats & Trends

Twins pitchers have a strikeout rate of just 17% in close and late situations this season — lowest in MLB.

Opponents have a groundball rate of just 40% against Twins pitchers this season — 3rd lowest in MLB.

Twins pitchers have a strikeout rate of just 19% with runners in scoring position this season — 3rd lowest in MLB.

Opponents have a miss rate of just 23% against Twins pitchers this season — tied for 2nd lowest in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

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