• The White Sox are -130 favorites vs the Astros
• Astros vs White Sox Over / Under today: 8.5 Runs
• Astros / White Sox TV Channel: CHSN | SCHN

The Houston Astros (+105) visit Rate Field to take on the Chicago White Sox (-130) on July 25, 2026. First pitch is scheduled for 7:10 pm in Chicago, IL.

This season, the Astros are 51-54 against the spread (ATS), while the White Sox are 57-42 ATS.

Astros vs White Sox Starting Pitchers Today:

• Astros starting pitcher: Hunter Brown 1-1, 4.05 ERA
• White Sox starting pitcher: Sean Burke 7-4, 3.20 ERA

Astros vs. White Sox Odds, Run Line, Over/Under & Moneyline

Astros vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the White Sox will win Saturday‘s MLB game with 56.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Astros vs White Sox and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

• Jeremy Pena has hit the Home Runs Over in 3 of his last 4 games (+16.90 Units / 422% ROI)
• Yordan Alvarez has hit the RBIs Under in 17 of his last 20 away games (+12.05 Units / 36% ROI)
• Yainer Diaz has hit the Total Bases Over in 14 of his last 20 away games (+11.30 Units / 49% ROI)
• Yordan Alvarez has hit the Hits Over in 8 of his last 10 games (+10.85 Units / 84% ROI)
• Isaac Paredes has hit the Singles Over in 17 of his last 25 games (+10.65 Units / 42% ROI)

And here are some favorite MLB player prop bets for White Sox players for Saturday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

• Drew Romo has hit the Hits Runs and RBIs Under in 17 of his last 20 games (+15.65 Units / 66% ROI)
• Drew Romo has hit the Singles Under in 18 of his last 20 games at home (+14.00 Units / 38% ROI)
• Drew Romo has hit the Runs Under in 18 of his last 20 games (+13.15 Units / 28% ROI)
• Drew Romo has hit the Hits Under in 16 of his last 20 games (+12.65 Units / 60% ROI)
• Drew Romo has hit the Total Bases Under in 16 of his last 20 games (+12.65 Units / 60% ROI)

Astros Best Bets Today:

• The Houston Astros have hit the Moneyline in 21 of their last 35 away games (+9.00 Units / 25% ROI)
• The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games (+7.05 Units / 14% ROI)
• The Houston Astros have hit the Team Total Over in 16 of their last 25 away games (+6.95 Units / 24% ROI)
• The Houston Astros have covered the Run Line in 22 of their last 35 away games (+6.25 Units / 12% ROI)
• The Houston Astros have hit the Game Total Over in 7 of their last 9 away games (+5.90 Units / 59% ROI)

White Sox Best Bets Today:

• The Chicago White Sox have hit the Moneyline in 28 of their last 40 games at home (+16.50 Units / 36% ROI)
• The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 21 of their last 30 games (+11.10 Units / 31% ROI)
• The Chicago White Sox have covered the Run Line in 23 of their last 35 games at home (+10.30 Units / 21% ROI)
• The Chicago White Sox have hit the Game Total Over in 18 of their last 30 games at home (+5.80 Units / 18% ROI)
• The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 7 of their last 10 games (+5.25 Units / 42% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 52-53 against the Run Line (-7.7 Units / -5.39% ROI).

• 51-54 when betting on the Moneyline for -6.2 Units / -5.15% ROI
• 54-45 when betting on the total runs Over for +3.6 Units / 3.08% ROI
• 45-54 when betting on the total runs Under for -14.05 Units / -12.3% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 57-42 against the Run Line (+3.1 Units / 2.13% ROI).

• 54-48 when betting on the Moneyline for +12.85 Units / 11.74% ROI
• 58-42 when betting on the total runs Over for +12 Units / 10.74% ROI
• 42-58 when betting on the total runs Under for -22.1 Units / -19.62% ROI

White Sox vs Astros Home Run Prop Bets Today

White Sox vs Astros Total Hits Prop Bets Today

White Sox vs Astros Strikeout Prop Bets Today

Astros Keys to the Game vs. the White Sox

The Astros are 9-4 (.692) when tied entering the 8th inning this season — 4th best in MLB; League Avg: .500.

The Astros are just 5-46 (.098) when trailing entering the 7th inning this season — 5th lowest in MLB; League Avg: .136.

The Astros are 45-0 (1.000) when leading entering the 9th inning this season — tied for best in MLB; League Avg: .948.

The Astros are just 22-28 (.440) after a win this season — 5th lowest in MLB; League Avg: .514.

White Sox Keys to the Game vs. the Astros

The White Sox are 31-18 (.633) at home this season — 2nd best in MLB; League Avg: .522.

The White Sox are just 4-24 (.143) when allowing 10 or more hits this season — 4th lowest in MLB; League Avg: .248.

The White Sox are 9-3 (.750) when tied entering the 7th inning this season — 3rd best in MLB; League Avg: .500.

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

Astros Hitting Stats & Trends

Astros hitters have 32 extra-base hits out of 121 total hits (just 26%) when facing the starting pitcher for the 3rd time in a game this season — 2nd lowest in MLB.

Astros hitters have an OBP of just .307 (1,934 PA’s) at home this season — 4th lowest in MLB.

Astros hitters have an OPS of .788 (932 PA’s) when leading off an inning this season — 3rd best in MLB.

The Astros have scored 204 runs with two outs this season — most in MLB.

White Sox Hitting Stats & Trends

White Sox hitters have 51 extra-base hits out of 103 total hits (49%) when facing the starting pitcher for the 3rd time in a game this season — best in MLB.

White Sox hitters have grounded into 46 double plays in 727 opportunities (6%) this season — 2nd best in MLB.

The White Sox are batting .261 on changeups this season — 2nd best in MLB.

29% of White Sox hitters strikeouts have come on 95+ MPH fastballs this season — 3rd highest in MLB.

Astros Pitching Stats & Trends

Astros pitchers have walked 11% of batters this season — highest in MLB.

Astros pitchers have walked 12% of batters when facing the leadoff batter in the inning this season — highest in MLB.

Opponents have a groundball rate of just 39% against Astros pitchers this season — 2nd lowest in MLB.

Astros pitchers have allowed opponents to score in three different innings in 55% of their games this season — 2nd highest in MLB.

White Sox Pitching Stats & Trends

The White Sox pitchers have allowed their opponents to score first in just 36% of their games on the road this season — 3rd lowest in MLB.

White Sox pitchers have walked 11% of batters when facing the leadoff batter in the inning this season — 2nd highest in MLB.

The White Sox have won 52% of home games in which their opponents scored first this season — 2nd highest in MLB.

White Sox pitchers have an ERA of 2.96 (267.1 IP) against division opponents this season — tied for 2nd best in MLB.

More MLB Reading:

• Home Run Predictions Today
• Best NRFI Bets Today
• Strikeout Props Today
• MLB Starting Pitchers Today

Bet now on Astros vs White Sox and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.